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- W4385232061 abstract "To review the pathophysiology and treatment of ocular itch and pain, encompassing nociceptive and neuropathic categories.Ocular itch and pain are sensations that arise from activation of ocular surface polymodal nerves. Nociceptive itch, commonly comorbid with ocular pain complaints, is mainly driven by a histamine-mediated type 1 hypersensitivity reaction. Beyond topical therapy, novel drug delivery systems are being explored to improve ocular residence time of nonsteroidal anti-inflammatory drugs (NSAIDs) and antihistamines. Nociceptive ocular pain can be driven by a variety of factors. Treatment focuses on addressing the causative sources of pain. Neuropathic ocular itch and pain are driven by nerve damage and dysfunction and as such, topical and oral neuromodulation have been explored as treatments. Oral neuromodulators include alpha 2 delta ligands, tricyclic antidepressants (TCAs), and low dose naltrexone. Novel therapies are being evaluated for both modalities such as difelikefalin (κ-opioid receptor agonist) for neuropathic itch and libvatrep (transient receptor potential vanilloid 1 antagonist) for neuropathic pain.Both ocular itch and pain can be driven by nociceptive and/or neuropathic mechanisms. Identifying contributors to abnormal ocular sensations is vital for precise medical care. Novel therapeutics for these conditions aim to improve patient outcomes and quality of life." @default.
- W4385232061 created "2023-07-26" @default.
- W4385232061 creator A5058460082 @default.
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- W4385232061 date "2023-07-24" @default.
- W4385232061 modified "2023-10-04" @default.
- W4385232061 title "Ocular surface itch and pain: key differences and similarities between the two sensations" @default.
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- W4385232061 doi "https://doi.org/10.1097/aci.0000000000000934" @default.
- W4385232061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37490616" @default.
- W4385232061 hasPublicationYear "2023" @default.
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