Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385235299> ?p ?o ?g. }
- W4385235299 endingPage "20354" @default.
- W4385235299 startingPage "20344" @default.
- W4385235299 abstract "Organic molecules that can be connected to multiple substrates by sequential C-C bond formations can be utilized as linchpins in multicomponent processes. While they are useful for rapidly increasing molecular complexity, most of the reported linchpin coupling methods rely on the use of organometallic species as strong carbon nucleophiles to form C-C bonds, which narrows the functional group compatibility. Here, we describe a metal-free, radical-mediated coupling approach using a formyl-stabilized phosphonium ylide as a multifunctional linchpin under visible-light photoredox conditions. The present method uses the ambiphilic character of the phosphonium ylide, which serves as both a nucleophilic and an electrophilic carbon-centered radical source. The stepwise and controllable generation of these radical intermediates allows sequential photocatalysis involving two mechanistically distinct radical additions, both of which are initiated by the same photocatalyst in one pot with high functional group tolerance. The methodology enables a bidirectional assembly of the linchpin with two electronically differentiated alkene fragments and thus offers rapid and modular access to 1,4-dicarbonyl compounds as versatile synthetic intermediates." @default.
- W4385235299 created "2023-07-26" @default.
- W4385235299 creator A5011356741 @default.
- W4385235299 creator A5061403783 @default.
- W4385235299 creator A5072986688 @default.
- W4385235299 date "2023-07-25" @default.
- W4385235299 modified "2023-10-16" @default.
- W4385235299 title "Bidirectional Elongation Strategy Using Ambiphilic Radical Linchpin for Modular Access to 1,4-Dicarbonyls via Sequential Photocatalysis" @default.
- W4385235299 cites W1966922056 @default.
- W4385235299 cites W1985088132 @default.
- W4385235299 cites W2007357086 @default.
- W4385235299 cites W2042083742 @default.
- W4385235299 cites W2056350589 @default.
- W4385235299 cites W2057351000 @default.
- W4385235299 cites W2070014766 @default.
- W4385235299 cites W2105492427 @default.
- W4385235299 cites W2114809965 @default.
- W4385235299 cites W2313003444 @default.
- W4385235299 cites W2341258349 @default.
- W4385235299 cites W2344923007 @default.
- W4385235299 cites W2418726947 @default.
- W4385235299 cites W2473962075 @default.
- W4385235299 cites W2504256884 @default.
- W4385235299 cites W2520813356 @default.
- W4385235299 cites W2759865530 @default.
- W4385235299 cites W2767295563 @default.
- W4385235299 cites W2783625414 @default.
- W4385235299 cites W2809176041 @default.
- W4385235299 cites W2886473418 @default.
- W4385235299 cites W2892905500 @default.
- W4385235299 cites W2896853542 @default.
- W4385235299 cites W2897531901 @default.
- W4385235299 cites W2903102095 @default.
- W4385235299 cites W2904940349 @default.
- W4385235299 cites W2917017563 @default.
- W4385235299 cites W2945662132 @default.
- W4385235299 cites W2949203278 @default.
- W4385235299 cites W2950502630 @default.
- W4385235299 cites W2959053971 @default.
- W4385235299 cites W2983316962 @default.
- W4385235299 cites W3001619876 @default.
- W4385235299 cites W3015485069 @default.
- W4385235299 cites W3016347392 @default.
- W4385235299 cites W3023369437 @default.
- W4385235299 cites W3047385792 @default.
- W4385235299 cites W3095837697 @default.
- W4385235299 cites W3120897700 @default.
- W4385235299 cites W3123565787 @default.
- W4385235299 cites W3164483471 @default.
- W4385235299 cites W3164838999 @default.
- W4385235299 cites W3167811481 @default.
- W4385235299 cites W3169609691 @default.
- W4385235299 cites W3188096523 @default.
- W4385235299 cites W3190144162 @default.
- W4385235299 cites W3197054232 @default.
- W4385235299 cites W3215361938 @default.
- W4385235299 cites W3216099841 @default.
- W4385235299 cites W4200623428 @default.
- W4385235299 cites W4224317417 @default.
- W4385235299 cites W4244452346 @default.
- W4385235299 cites W4254987954 @default.
- W4385235299 cites W4281554150 @default.
- W4385235299 cites W4289261332 @default.
- W4385235299 cites W4308469635 @default.
- W4385235299 cites W4315620819 @default.
- W4385235299 cites W4316495393 @default.
- W4385235299 doi "https://doi.org/10.1021/jacs.3c05337" @default.
- W4385235299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37490759" @default.
- W4385235299 hasPublicationYear "2023" @default.
- W4385235299 type Work @default.
- W4385235299 citedByCount "0" @default.
- W4385235299 crossrefType "journal-article" @default.
- W4385235299 hasAuthorship W4385235299A5011356741 @default.
- W4385235299 hasAuthorship W4385235299A5061403783 @default.
- W4385235299 hasAuthorship W4385235299A5072986688 @default.
- W4385235299 hasConcept C160964918 @default.
- W4385235299 hasConcept C161790260 @default.
- W4385235299 hasConcept C178790620 @default.
- W4385235299 hasConcept C178907741 @default.
- W4385235299 hasConcept C185592680 @default.
- W4385235299 hasConcept C21951064 @default.
- W4385235299 hasConcept C2776254738 @default.
- W4385235299 hasConcept C2777332933 @default.
- W4385235299 hasConcept C2779167645 @default.
- W4385235299 hasConcept C2780707935 @default.
- W4385235299 hasConcept C50027330 @default.
- W4385235299 hasConcept C521977710 @default.
- W4385235299 hasConcept C65165184 @default.
- W4385235299 hasConcept C71240020 @default.
- W4385235299 hasConcept C75473681 @default.
- W4385235299 hasConceptScore W4385235299C160964918 @default.
- W4385235299 hasConceptScore W4385235299C161790260 @default.
- W4385235299 hasConceptScore W4385235299C178790620 @default.
- W4385235299 hasConceptScore W4385235299C178907741 @default.
- W4385235299 hasConceptScore W4385235299C185592680 @default.
- W4385235299 hasConceptScore W4385235299C21951064 @default.
- W4385235299 hasConceptScore W4385235299C2776254738 @default.
- W4385235299 hasConceptScore W4385235299C2777332933 @default.