FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385237639> ?p ?o ?g. }

• W4385237639 abstract "Background The ATN model represents a research framework used to describe in subjects the presence or absence of Alzheimer’s disease (AD) pathology through biomarkers. The aim of this study was to describe the prevalence of different ATN profiles using quantitative imaging biomarkers in two independent cohorts, and to evaluate the pertinence of ATN biomarkers to identify comparable populations across independent cohorts. Methods A total of 172 subjects from the Geneva Memory Clinic and 113 volunteers from a study on healthy aging at the University Hospital of Zurich underwent amyloid (A) and tau (T) PET, as well as T1-weigthed MRI scans using site-specific protocols. Subjects were classified by cognition (cognitively unimpaired, CU, or impaired, CI) based on clinical assessment by experts. Amyloid data converted into the standardized centiloid scale, tau PET data normalized to cerebellar uptake, and hippocampal volume expressed as a ratio over total intracranial volume ratio were considered as biomarkers for A, T, and neurodegeneration (N), respectively. Positivity for each biomarker was defined based on previously published thresholds. Subjects were then classified according to the ATN model. Differences among profiles were tested using Kruskal-Wallis ANOVA, and between cohorts using Wilcoxon tests. Results Twenty-nine percent of subjects from the Geneva cohorts were classified with a normal (A−T−N−) profile, while the Zurich cohort included 64% of subjects in the same category. Meanwhile, 63% of the Geneva and 16% of the Zurich cohort were classified within the AD continuum (being A+ regardless of other biomarkers’ statuses). Within cohorts, ATN profiles were significantly different for age and mini-mental state examination scores, but not for years of education. Age was not significantly different between cohorts. In general, imaging A and T biomarkers were significantly different between cohorts, but they were no longer significantly different when stratifying the cohorts by ATN profile. N was not significantly different between cohorts. Conclusion Stratifying subjects into ATN profiles provides comparable groups of subjects even when individual recruitment followed different criteria." @default.
• W4385237639 created "2023-07-26" @default.
• W4385237639 creator A5014971081 @default.
• W4385237639 creator A5036774533 @default.
• W4385237639 creator A5037620274 @default.
• W4385237639 creator A5038509881 @default.
• W4385237639 creator A5049919895 @default.
• W4385237639 creator A5051868596 @default.
• W4385237639 creator A5066000640 @default.
• W4385237639 creator A5068721045 @default.
• W4385237639 creator A5086913074 @default.
• W4385237639 date "2023-07-25" @default.
• W4385237639 modified "2023-09-25" @default.
• W4385237639 title "ATN profile classification across two independent prospective cohorts" @default.
• W4385237639 cites W1771725737 @default.
• W4385237639 cites W1831805455 @default.
• W4385237639 cites W2055649795 @default.
• W4385237639 cites W2058046532 @default.
• W4385237639 cites W2067145795 @default.
• W4385237639 cites W2102961599 @default.
• W4385237639 cites W2107202876 @default.
• W4385237639 cites W2115017507 @default.
• W4385237639 cites W2124030567 @default.
• W4385237639 cites W2133649359 @default.
• W4385237639 cites W2149862198 @default.
• W4385237639 cites W2153859664 @default.
• W4385237639 cites W2473313434 @default.
• W4385237639 cites W2582524520 @default.
• W4385237639 cites W2738088587 @default.
• W4385237639 cites W2781092115 @default.
• W4385237639 cites W2792709687 @default.
• W4385237639 cites W2795642715 @default.
• W4385237639 cites W2797129551 @default.
• W4385237639 cites W2798054687 @default.
• W4385237639 cites W2801498551 @default.
• W4385237639 cites W2801678998 @default.
• W4385237639 cites W2804965523 @default.
• W4385237639 cites W2809499549 @default.
• W4385237639 cites W2849227165 @default.
• W4385237639 cites W2903032912 @default.
• W4385237639 cites W2923868521 @default.
• W4385237639 cites W2971263658 @default.
• W4385237639 cites W2973007151 @default.
• W4385237639 cites W2979624665 @default.
• W4385237639 cites W2989237197 @default.
• W4385237639 cites W2989567179 @default.
• W4385237639 cites W3016083720 @default.
• W4385237639 cites W3023013291 @default.
• W4385237639 cites W3025228866 @default.
• W4385237639 cites W3026056964 @default.
• W4385237639 cites W3033804370 @default.
• W4385237639 cites W3087227263 @default.
• W4385237639 cites W3111650712 @default.
• W4385237639 cites W3133730557 @default.
• W4385237639 cites W3135004658 @default.
• W4385237639 cites W3135994341 @default.
• W4385237639 cites W3173455631 @default.
• W4385237639 cites W3176722257 @default.
• W4385237639 cites W3183927686 @default.
• W4385237639 cites W3195656026 @default.
• W4385237639 cites W3204314450 @default.
• W4385237639 cites W4224940301 @default.
• W4385237639 cites W4225589542 @default.
• W4385237639 cites W4230920194 @default.
• W4385237639 cites W4241074797 @default.
• W4385237639 cites W4385684558 @default.
• W4385237639 doi "https://doi.org/10.3389/fmed.2023.1168470" @default.
• W4385237639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37559930" @default.
• W4385237639 hasPublicationYear "2023" @default.
• W4385237639 type Work @default.
• W4385237639 citedByCount "0" @default.
• W4385237639 crossrefType "journal-article" @default.
• W4385237639 hasAuthorship W4385237639A5014971081 @default.
• W4385237639 hasAuthorship W4385237639A5036774533 @default.
• W4385237639 hasAuthorship W4385237639A5037620274 @default.
• W4385237639 hasAuthorship W4385237639A5038509881 @default.
• W4385237639 hasAuthorship W4385237639A5049919895 @default.
• W4385237639 hasAuthorship W4385237639A5051868596 @default.
• W4385237639 hasAuthorship W4385237639A5066000640 @default.
• W4385237639 hasAuthorship W4385237639A5068721045 @default.
• W4385237639 hasAuthorship W4385237639A5086913074 @default.
• W4385237639 hasBestOaLocation W43852376391 @default.
• W4385237639 hasConcept C126322002 @default.
• W4385237639 hasConcept C142724271 @default.
• W4385237639 hasConcept C143998085 @default.
• W4385237639 hasConcept C185592680 @default.
• W4385237639 hasConcept C188816634 @default.
• W4385237639 hasConcept C201903717 @default.
• W4385237639 hasConcept C2776925932 @default.
• W4385237639 hasConcept C2779134260 @default.
• W4385237639 hasConcept C2779483572 @default.
• W4385237639 hasConcept C2781197716 @default.
• W4385237639 hasConcept C55493867 @default.
• W4385237639 hasConcept C71924100 @default.
• W4385237639 hasConcept C72563966 @default.
• W4385237639 hasConceptScore W4385237639C126322002 @default.
• W4385237639 hasConceptScore W4385237639C142724271 @default.
• W4385237639 hasConceptScore W4385237639C143998085 @default.
• W4385237639 hasConceptScore W4385237639C185592680 @default.
• W4385237639 hasConceptScore W4385237639C188816634 @default.

• next