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- W4385246376 abstract "The sodium-activated Slo2.2 channel is abundantly expressed in the brain, playing a critical role in regulating neuronal excitability. The Na+-binding site and the underlying mechanisms of Na+-dependent activation remain unclear. Here, we present cryoelectron microscopy (cryo-EM) structures of human Slo2.2 in closed, open, and inhibitor-bound form at resolutions of 2.6–3.2 Å, revealing gating mechanisms of Slo2.2 regulation by cations and a potent inhibitor. The cytoplasmic gating ring domain of the closed Slo2.2 harbors multiple K+ and Zn2+ sites, which stabilize the channel in the closed conformation. The open Slo2.2 structure reveals at least two Na+-sensitive sites where Na+ binding induces expansion and rotation of the gating ring that opens the inner gate. Furthermore, a potent inhibitor wedges into a pocket formed by pore helix and S6 helix and blocks the pore. Together, our results provide a comprehensive structural framework for the investigation of Slo2.2 channel gating, Na+ sensation, and inhibition." @default.
- W4385246376 created "2023-07-26" @default.
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- W4385246376 date "2023-08-01" @default.
- W4385246376 modified "2023-10-17" @default.
- W4385246376 title "Structural basis of human Slo2.2 channel gating and modulation" @default.
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- W4385246376 cites W2006053579 @default.
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- W4385246376 cites W2007850520 @default.
- W4385246376 cites W2011920501 @default.
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- W4385246376 cites W2021520922 @default.
- W4385246376 cites W2021958245 @default.
- W4385246376 cites W2028511100 @default.
- W4385246376 cites W2034651748 @default.
- W4385246376 cites W2035266068 @default.
- W4385246376 cites W2043162533 @default.
- W4385246376 cites W2049627978 @default.
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- W4385246376 cites W2587625522 @default.
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- W4385246376 cites W2950967305 @default.
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- W4385246376 doi "https://doi.org/10.1016/j.celrep.2023.112858" @default.
- W4385246376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37494189" @default.
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