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- W4385252009 abstract "Rapid eye movement sleep (REMS) is essential for leading normal healthy living at least in higher-order mammals, including humans. In this review, we briefly survey the available literature for evidence linking cytomorphometric changes in the brain due to loss of REMS. As a mechanism of action, we add evidence that REMS loss elevates noradrenaline (NA) levels in the brain, which affects neuronal cytomorphology. These changes may be a compensatory mechanism as the changes return to normal after the subjects recover from the loss of REMS or if during REMS deprivation, the subjects are treated with NA-adrenoceptor antagonist prazosin (PRZ). We had proposed earlier that one of the fundamental functions of REMS is to maintain the level of NA in the brain. We elaborate on this idea to propose that if REMS loss continues without recovery, the sustained level of NA breaks down neurophysiologically active compensatory mechanism/s starting with changes in the neuronal cytomorphology, followed by their degeneration, leading to acute and chronic pathological conditions. Identification of neuronal cytomorphological changes could prove to be of significance for predicting future neuronal (brain) damage as well as an indicator for REMS health. Although current brain imaging techniques may not enable us to visualize changes in neuronal cytomorphology, given the rapid technological progress including use of artificial intelligence, we are optimistic that it may be a reality soon. Finally, we propose that maintenance of optimum REMS must be considered a criterion for leading a healthy life." @default.
- W4385252009 created "2023-07-26" @default.
- W4385252009 creator A5007768984 @default.
- W4385252009 creator A5062609491 @default.
- W4385252009 creator A5075256126 @default.
- W4385252009 date "2023-10-01" @default.
- W4385252009 modified "2023-10-08" @default.
- W4385252009 title "Rapid eye movement sleep loss associated cytomorphometric changes and neurodegeneration" @default.
- W4385252009 cites W1496192870 @default.
- W4385252009 cites W1503558664 @default.
- W4385252009 cites W1589415602 @default.
- W4385252009 cites W181383598 @default.
- W4385252009 cites W1963649284 @default.
- W4385252009 cites W1964577928 @default.
- W4385252009 cites W1967515685 @default.
- W4385252009 cites W1972287997 @default.
- W4385252009 cites W1982180120 @default.
- W4385252009 cites W1982283077 @default.
- W4385252009 cites W1983003665 @default.
- W4385252009 cites W1984090112 @default.
- W4385252009 cites W1993249717 @default.
- W4385252009 cites W1993259981 @default.
- W4385252009 cites W1995920929 @default.
- W4385252009 cites W2007746893 @default.
- W4385252009 cites W2007803760 @default.
- W4385252009 cites W2008479667 @default.
- W4385252009 cites W2014558459 @default.
- W4385252009 cites W2014824152 @default.
- W4385252009 cites W2017361394 @default.
- W4385252009 cites W2019378652 @default.
- W4385252009 cites W2022024201 @default.
- W4385252009 cites W2022130723 @default.
- W4385252009 cites W2025400114 @default.
- W4385252009 cites W2026140567 @default.
- W4385252009 cites W2036873071 @default.
- W4385252009 cites W2038291091 @default.
- W4385252009 cites W2038963210 @default.
- W4385252009 cites W2039649121 @default.
- W4385252009 cites W2039844429 @default.
- W4385252009 cites W2040894493 @default.
- W4385252009 cites W2041354320 @default.
- W4385252009 cites W2041858803 @default.
- W4385252009 cites W2042931046 @default.
- W4385252009 cites W2046405003 @default.
- W4385252009 cites W2046908130 @default.
- W4385252009 cites W2047283398 @default.
- W4385252009 cites W2048300513 @default.
- W4385252009 cites W2048763905 @default.
- W4385252009 cites W2050740583 @default.
- W4385252009 cites W2050802655 @default.
- W4385252009 cites W2051923190 @default.
- W4385252009 cites W2055209937 @default.
- W4385252009 cites W2060679526 @default.
- W4385252009 cites W2061760084 @default.
- W4385252009 cites W2064412709 @default.
- W4385252009 cites W2067367912 @default.
- W4385252009 cites W2068307263 @default.
- W4385252009 cites W2069385089 @default.
- W4385252009 cites W2071233773 @default.
- W4385252009 cites W2071905411 @default.
- W4385252009 cites W2072195654 @default.
- W4385252009 cites W2073062190 @default.
- W4385252009 cites W2080739364 @default.
- W4385252009 cites W2085992732 @default.
- W4385252009 cites W2087202696 @default.
- W4385252009 cites W2090491376 @default.
- W4385252009 cites W2094316274 @default.
- W4385252009 cites W2097005988 @default.
- W4385252009 cites W2099096099 @default.
- W4385252009 cites W2106545511 @default.
- W4385252009 cites W2109447349 @default.
- W4385252009 cites W2124046255 @default.
- W4385252009 cites W2129951633 @default.
- W4385252009 cites W2136148158 @default.
- W4385252009 cites W2139093186 @default.
- W4385252009 cites W2140117942 @default.
- W4385252009 cites W2142145769 @default.
- W4385252009 cites W2144059033 @default.
- W4385252009 cites W2144415082 @default.
- W4385252009 cites W2144504620 @default.
- W4385252009 cites W2145053522 @default.
- W4385252009 cites W2146427423 @default.
- W4385252009 cites W2146551296 @default.
- W4385252009 cites W2150424386 @default.
- W4385252009 cites W2164153190 @default.
- W4385252009 cites W2165703369 @default.
- W4385252009 cites W2263173985 @default.
- W4385252009 cites W2270489524 @default.
- W4385252009 cites W2303406433 @default.
- W4385252009 cites W2316754223 @default.
- W4385252009 cites W2343125660 @default.
- W4385252009 cites W2414339116 @default.
- W4385252009 cites W2500340790 @default.
- W4385252009 cites W2558106912 @default.
- W4385252009 cites W2596672065 @default.
- W4385252009 cites W2607360751 @default.
- W4385252009 cites W2612279970 @default.
- W4385252009 cites W2765993789 @default.