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- W4385255005 abstract "The development of subunit vaccine platforms has been of considerable interest due to their good safety profile and ability to be adapted to new antigens, compared to other vaccine typess. Nevertheless, subunit vaccines often lack sufficient immunogenicity to fully protect against infectious diseases. A wide variety of subunit vaccines have been developed to enhance antigen immunogenicity by increasing antigen multivalency, as well as stability and delivery properties, via presentation of antigens on protein nanoparticles. Increasing multivalency can be an effective approach to provide a potent humoral immune response by more strongly engaging and clustering B cell receptors (BCRs) to induce activation, as well as increased uptake by antigen presenting cells and their subsequent T cell activation. Proper orientation of antigen on protein nanoparticles is also considered a crucial factor for enhanced BCR engagement and subsequent immune responses. Therefore, various strategies have been reported to decorate highly repetitive surfaces of protein nanoparticle scaffolds with multiple copies of antigens, arrange antigens in proper orientation, or combinations thereof. In this review, we describe different chemical bioconjugation methods, approaches for genetic fusion of recombinant antigens, biological affinity tags, and enzymatic conjugation methods to effectively present antigens on the surface of protein nanoparticle vaccine scaffolds." @default.
- W4385255005 created "2023-07-26" @default.
- W4385255005 creator A5038617325 @default.
- W4385255005 creator A5060132590 @default.
- W4385255005 creator A5065112589 @default.
- W4385255005 date "2023-07-25" @default.
- W4385255005 modified "2023-10-17" @default.
- W4385255005 title "Chemical and biological conjugation strategies for the development of multivalent protein vaccine nanoparticles" @default.
- W4385255005 cites W114472580 @default.
- W4385255005 cites W1504983613 @default.
- W4385255005 cites W1596206099 @default.
- W4385255005 cites W1606977653 @default.
- W4385255005 cites W1947712816 @default.
- W4385255005 cites W1967781933 @default.
- W4385255005 cites W1976672416 @default.
- W4385255005 cites W1997099073 @default.
- W4385255005 cites W1998989840 @default.
- W4385255005 cites W2002844537 @default.
- W4385255005 cites W2003000365 @default.
- W4385255005 cites W2019910161 @default.
- W4385255005 cites W2025554794 @default.
- W4385255005 cites W2027498023 @default.
- W4385255005 cites W2029793786 @default.
- W4385255005 cites W2033357990 @default.
- W4385255005 cites W2046182783 @default.
- W4385255005 cites W2052731133 @default.
- W4385255005 cites W2062843499 @default.
- W4385255005 cites W2072794252 @default.
- W4385255005 cites W2078364862 @default.
- W4385255005 cites W2096428863 @default.
- W4385255005 cites W2114926334 @default.
- W4385255005 cites W2122562716 @default.
- W4385255005 cites W2139132743 @default.
- W4385255005 cites W2140205268 @default.
- W4385255005 cites W21407630 @default.
- W4385255005 cites W2149781357 @default.
- W4385255005 cites W2151727763 @default.
- W4385255005 cites W2156801977 @default.
- W4385255005 cites W216353729 @default.
- W4385255005 cites W2163951861 @default.
- W4385255005 cites W2165691323 @default.
- W4385255005 cites W2165899507 @default.
- W4385255005 cites W2166911920 @default.
- W4385255005 cites W2175888490 @default.
- W4385255005 cites W2196578399 @default.
- W4385255005 cites W2239748356 @default.
- W4385255005 cites W2263431558 @default.
- W4385255005 cites W2297951781 @default.
- W4385255005 cites W2302354170 @default.
- W4385255005 cites W2318749007 @default.
- W4385255005 cites W2346355391 @default.
- W4385255005 cites W2346640216 @default.
- W4385255005 cites W2386602908 @default.
- W4385255005 cites W2409675885 @default.
- W4385255005 cites W2491008760 @default.
- W4385255005 cites W2520932585 @default.
- W4385255005 cites W2552647476 @default.
- W4385255005 cites W2560251643 @default.
- W4385255005 cites W2599985910 @default.
- W4385255005 cites W2605502565 @default.
- W4385255005 cites W2606020258 @default.
- W4385255005 cites W2607918806 @default.
- W4385255005 cites W2616129231 @default.
- W4385255005 cites W2625783350 @default.
- W4385255005 cites W2750997098 @default.
- W4385255005 cites W2753483322 @default.
- W4385255005 cites W2758624951 @default.
- W4385255005 cites W2771036858 @default.
- W4385255005 cites W2785232134 @default.
- W4385255005 cites W2788842288 @default.
- W4385255005 cites W2790423529 @default.
- W4385255005 cites W2792840177 @default.
- W4385255005 cites W2803836967 @default.
- W4385255005 cites W2804954175 @default.
- W4385255005 cites W2884027472 @default.
- W4385255005 cites W2886207362 @default.
- W4385255005 cites W2887114604 @default.
- W4385255005 cites W2890139013 @default.
- W4385255005 cites W2895464494 @default.
- W4385255005 cites W2908328357 @default.
- W4385255005 cites W2921076844 @default.
- W4385255005 cites W2921503601 @default.
- W4385255005 cites W2944601565 @default.
- W4385255005 cites W2945830776 @default.
- W4385255005 cites W2946008634 @default.
- W4385255005 cites W2946651253 @default.
- W4385255005 cites W2946780045 @default.
- W4385255005 cites W2946910603 @default.
- W4385255005 cites W2948588867 @default.
- W4385255005 cites W2953283118 @default.
- W4385255005 cites W2953721817 @default.
- W4385255005 cites W2954687111 @default.
- W4385255005 cites W2962608708 @default.
- W4385255005 cites W2976620503 @default.
- W4385255005 cites W2979899363 @default.
- W4385255005 cites W2981511000 @default.
- W4385255005 cites W2999754980 @default.
- W4385255005 cites W3004549682 @default.
- W4385255005 cites W3007643904 @default.
- W4385255005 cites W3014221482 @default.