FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385255504> ?p ?o ?g. }

• W4385255504 abstract "Abstract Background Keloids are an excessive growth of skin fibres that occur during the pathological wound healing process following skin injury. Although the use of adipose-derived mesenchymal stem cells (ADSCs) to treat keloids and their anti-fibrotic effects have been a subject of intense research, the precise mechanism and efficacy of this therapy remain unclear. This study aimed to identify an effective ADSC therapy for keloids. Methods We compared the transcriptome characteristics of keloid fibroblasts (KF) and normal fibroblasts, as well as keloid keratinocytes (KK) and normal keratinocytes. Using differentially expressed gene analysis, gene set enrichment analysis, protein-protein interaction network analysis, hub gene analysis, and transcription factor regulation analysis; we identified the molecular characteristics underlying keloid pathogenesis. Furthermore, we used single-cell RNA sequencing and bioinformatics analysis to identify functional ADSC subclusters with inhibitory effects on keloid development. Finally, we investigated the effectiveness of the identified ADSC subclusters in preventing hypertrophic scar formation using a miniature pig model. Results We found that genes such as NOG and IL6 were up-regulated in KF, and interacted with other molecules to promote immune regulation, angiogenesis, and tissue regeneration, leading to the formation of KF. In KK, genes such as APP, NOTCH1 regulated migration, invasion, proliferation and fate determination of cells, leading to the formation of KK. We successfully identified hADSC subclusters that inhibited the development of KF, KK, or both, and miniature pigs treated by pADSCs with higher ratio of these therapeutic clusters shown better hypertrophic scar prophylaxis. Conclusion Our study provides a comprehensive understanding of the molecular characteristics of the keloid in humans, and is the first to identify therapeutic ADSC clusters for keloids, offering new avenues for stem cell-based keloid treatments." @default.
• W4385255504 created "2023-07-26" @default.
• W4385255504 creator A5004299785 @default.
• W4385255504 creator A5019224827 @default.
• W4385255504 creator A5035442587 @default.
• W4385255504 creator A5035520440 @default.
• W4385255504 creator A5044511016 @default.
• W4385255504 creator A5045268996 @default.
• W4385255504 creator A5050619645 @default.
• W4385255504 creator A5074748619 @default.
• W4385255504 creator A5076699095 @default.
• W4385255504 creator A5081247905 @default.
• W4385255504 date "2023-07-25" @default.
• W4385255504 modified "2023-09-22" @default.
• W4385255504 title "An advanced ADSC therapy for keloid prevention using identification of functional subgroups by single cell transcriptomic analysis" @default.
• W4385255504 cites W1600024584 @default.
• W4385255504 cites W1920534265 @default.
• W4385255504 cites W2022434893 @default.
• W4385255504 cites W2025371271 @default.
• W4385255504 cites W2034465101 @default.
• W4385255504 cites W2051579708 @default.
• W4385255504 cites W2076073501 @default.
• W4385255504 cites W2077877274 @default.
• W4385255504 cites W2109898736 @default.
• W4385255504 cites W2136244567 @default.
• W4385255504 cites W2156841731 @default.
• W4385255504 cites W2173497140 @default.
• W4385255504 cites W2201248084 @default.
• W4385255504 cites W2209427166 @default.
• W4385255504 cites W2226157037 @default.
• W4385255504 cites W2396068690 @default.
• W4385255504 cites W2468603755 @default.
• W4385255504 cites W2590599688 @default.
• W4385255504 cites W2607866711 @default.
• W4385255504 cites W2747489535 @default.
• W4385255504 cites W2777807685 @default.
• W4385255504 cites W2793299965 @default.
• W4385255504 cites W2808158796 @default.
• W4385255504 cites W2889389523 @default.
• W4385255504 cites W2909425723 @default.
• W4385255504 cites W2910093743 @default.
• W4385255504 cites W2911567764 @default.
• W4385255504 cites W2928665623 @default.
• W4385255504 cites W2993856600 @default.
• W4385255504 cites W2999553836 @default.
• W4385255504 cites W3030982632 @default.
• W4385255504 cites W3043859986 @default.
• W4385255504 cites W3044491460 @default.
• W4385255504 cites W3112737770 @default.
• W4385255504 cites W3193984537 @default.
• W4385255504 cites W4220659756 @default.
• W4385255504 cites W4220988689 @default.
• W4385255504 cites W4289745712 @default.
• W4385255504 cites W1978394952 @default.
• W4385255504 doi "https://doi.org/10.21203/rs.3.rs-2984650/v1" @default.
• W4385255504 hasPublicationYear "2023" @default.
• W4385255504 type Work @default.
• W4385255504 citedByCount "0" @default.
• W4385255504 crossrefType "posted-content" @default.
• W4385255504 hasAuthorship W4385255504A5004299785 @default.
• W4385255504 hasAuthorship W4385255504A5019224827 @default.
• W4385255504 hasAuthorship W4385255504A5035442587 @default.
• W4385255504 hasAuthorship W4385255504A5035520440 @default.
• W4385255504 hasAuthorship W4385255504A5044511016 @default.
• W4385255504 hasAuthorship W4385255504A5045268996 @default.
• W4385255504 hasAuthorship W4385255504A5050619645 @default.
• W4385255504 hasAuthorship W4385255504A5074748619 @default.
• W4385255504 hasAuthorship W4385255504A5076699095 @default.
• W4385255504 hasAuthorship W4385255504A5081247905 @default.
• W4385255504 hasBestOaLocation W43852555041 @default.
• W4385255504 hasConcept C104317684 @default.
• W4385255504 hasConcept C105702510 @default.
• W4385255504 hasConcept C142724271 @default.
• W4385255504 hasConcept C150194340 @default.
• W4385255504 hasConcept C153911025 @default.
• W4385255504 hasConcept C162317418 @default.
• W4385255504 hasConcept C203014093 @default.
• W4385255504 hasConcept C2777538232 @default.
• W4385255504 hasConcept C2778698245 @default.
• W4385255504 hasConcept C2780269544 @default.
• W4385255504 hasConcept C2780394083 @default.
• W4385255504 hasConcept C502942594 @default.
• W4385255504 hasConcept C54355233 @default.
• W4385255504 hasConcept C71924100 @default.
• W4385255504 hasConcept C86803240 @default.
• W4385255504 hasConcept C95444343 @default.
• W4385255504 hasConceptScore W4385255504C104317684 @default.
• W4385255504 hasConceptScore W4385255504C105702510 @default.
• W4385255504 hasConceptScore W4385255504C142724271 @default.
• W4385255504 hasConceptScore W4385255504C150194340 @default.
• W4385255504 hasConceptScore W4385255504C153911025 @default.
• W4385255504 hasConceptScore W4385255504C162317418 @default.
• W4385255504 hasConceptScore W4385255504C203014093 @default.
• W4385255504 hasConceptScore W4385255504C2777538232 @default.
• W4385255504 hasConceptScore W4385255504C2778698245 @default.
• W4385255504 hasConceptScore W4385255504C2780269544 @default.
• W4385255504 hasConceptScore W4385255504C2780394083 @default.
• W4385255504 hasConceptScore W4385255504C502942594 @default.
• W4385255504 hasConceptScore W4385255504C54355233 @default.
• W4385255504 hasConceptScore W4385255504C71924100 @default.

• next