FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385263726> ?p ?o ?g. }

• W4385263726 abstract "Covariate identification is an important step in the development of a population pharmacokinetic/pharmacodynamic model. Among the different available approaches, the stepwise covariate model (SCM) is the most used. However, SCM is based on a local search strategy, in which the model-building process iteratively tests the addition or elimination of a single covariate at a time given all the others. This introduces a heuristic to limit the searching space and then the computational complexity, but, at the same time, can lead to a suboptimal solution. The application of genetic algorithms (GAs) for covariate selection has been proposed as a possible solution to overcome these limitations. However, their actual use during model building is limited by the extremely high computational costs and convergence issues, both related to the number of models being tested. In this paper, we proposed a new GA for covariate selection to address these challenges. The GA was first developed on a simulated case study where the heuristics introduced to overcome the limitations affecting currently available GA approaches resulted able to limit the selection of redundant covariates, increase replicability of results and reduce convergence times. Then, we tested the proposed GA on a real-world problem related to remifentanil. It obtained good results both in terms of selected covariates and fitness optimization, outperforming the SCM." @default.
• W4385263726 created "2023-07-27" @default.
• W4385263726 creator A5004329154 @default.
• W4385263726 creator A5009919100 @default.
• W4385263726 creator A5063514910 @default.
• W4385263726 creator A5081448028 @default.
• W4385263726 date "2023-07-26" @default.
• W4385263726 modified "2023-09-23" @default.
• W4385263726 title "Go beyond the limits of genetic algorithm in daily covariate selection practice" @default.
• W4385263726 cites W1506604424 @default.
• W4385263726 cites W1509693321 @default.
• W4385263726 cites W1592005000 @default.
• W4385263726 cites W160670607 @default.
• W4385263726 cites W1974884708 @default.
• W4385263726 cites W1981213098 @default.
• W4385263726 cites W1998163185 @default.
• W4385263726 cites W1999337518 @default.
• W4385263726 cites W2052779929 @default.
• W4385263726 cites W2065831867 @default.
• W4385263726 cites W2066996342 @default.
• W4385263726 cites W2071806120 @default.
• W4385263726 cites W2117825133 @default.
• W4385263726 cites W2170509755 @default.
• W4385263726 cites W2473238561 @default.
• W4385263726 cites W2488700677 @default.
• W4385263726 cites W2570516417 @default.
• W4385263726 cites W2585254554 @default.
• W4385263726 cites W2904637438 @default.
• W4385263726 cites W2941422160 @default.
• W4385263726 cites W2999568963 @default.
• W4385263726 cites W2999839733 @default.
• W4385263726 cites W3131105603 @default.
• W4385263726 cites W3136441044 @default.
• W4385263726 cites W3161192826 @default.
• W4385263726 cites W3163061092 @default.
• W4385263726 cites W3177116930 @default.
• W4385263726 cites W3186138608 @default.
• W4385263726 cites W3203569786 @default.
• W4385263726 cites W3210424514 @default.
• W4385263726 cites W4210262873 @default.
• W4385263726 cites W4254460084 @default.
• W4385263726 cites W4297922645 @default.
• W4385263726 doi "https://doi.org/10.1007/s10928-023-09875-7" @default.
• W4385263726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37493851" @default.
• W4385263726 hasPublicationYear "2023" @default.
• W4385263726 type Work @default.
• W4385263726 citedByCount "0" @default.
• W4385263726 crossrefType "journal-article" @default.
• W4385263726 hasAuthorship W4385263726A5004329154 @default.
• W4385263726 hasAuthorship W4385263726A5009919100 @default.
• W4385263726 hasAuthorship W4385263726A5063514910 @default.
• W4385263726 hasAuthorship W4385263726A5081448028 @default.
• W4385263726 hasBestOaLocation W43852637261 @default.
• W4385263726 hasConcept C11413529 @default.
• W4385263726 hasConcept C116834253 @default.
• W4385263726 hasConcept C119043178 @default.
• W4385263726 hasConcept C119857082 @default.
• W4385263726 hasConcept C126255220 @default.
• W4385263726 hasConcept C127705205 @default.
• W4385263726 hasConcept C134306372 @default.
• W4385263726 hasConcept C151201525 @default.
• W4385263726 hasConcept C162324750 @default.
• W4385263726 hasConcept C173801870 @default.
• W4385263726 hasConcept C2777303404 @default.
• W4385263726 hasConcept C2908647359 @default.
• W4385263726 hasConcept C33923547 @default.
• W4385263726 hasConcept C41008148 @default.
• W4385263726 hasConcept C50522688 @default.
• W4385263726 hasConcept C59822182 @default.
• W4385263726 hasConcept C71924100 @default.
• W4385263726 hasConcept C81917197 @default.
• W4385263726 hasConcept C86803240 @default.
• W4385263726 hasConcept C8880873 @default.
• W4385263726 hasConcept C99454951 @default.
• W4385263726 hasConceptScore W4385263726C11413529 @default.
• W4385263726 hasConceptScore W4385263726C116834253 @default.
• W4385263726 hasConceptScore W4385263726C119043178 @default.
• W4385263726 hasConceptScore W4385263726C119857082 @default.
• W4385263726 hasConceptScore W4385263726C126255220 @default.
• W4385263726 hasConceptScore W4385263726C127705205 @default.
• W4385263726 hasConceptScore W4385263726C134306372 @default.
• W4385263726 hasConceptScore W4385263726C151201525 @default.
• W4385263726 hasConceptScore W4385263726C162324750 @default.
• W4385263726 hasConceptScore W4385263726C173801870 @default.
• W4385263726 hasConceptScore W4385263726C2777303404 @default.
• W4385263726 hasConceptScore W4385263726C2908647359 @default.
• W4385263726 hasConceptScore W4385263726C33923547 @default.
• W4385263726 hasConceptScore W4385263726C41008148 @default.
• W4385263726 hasConceptScore W4385263726C50522688 @default.
• W4385263726 hasConceptScore W4385263726C59822182 @default.
• W4385263726 hasConceptScore W4385263726C71924100 @default.
• W4385263726 hasConceptScore W4385263726C81917197 @default.
• W4385263726 hasConceptScore W4385263726C86803240 @default.
• W4385263726 hasConceptScore W4385263726C8880873 @default.
• W4385263726 hasConceptScore W4385263726C99454951 @default.
• W4385263726 hasFunder F4320322874 @default.
• W4385263726 hasLocation W43852637261 @default.
• W4385263726 hasLocation W43852637262 @default.
• W4385263726 hasLocation W43852637263 @default.
• W4385263726 hasOpenAccess W4385263726 @default.

• next