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- W4385263910 abstract "Respiratory syncytial virus (RSV) is the leading cause of pediatric lower respiratory illness (LRI) and a vaccine for immunization of children is needed. RSV/6120/ΔNS2/1030s is a cDNA-derived live-vaccine candidate attenuated by deletion of the interferon antagonist NS2 gene and the genetically-stabilized 1030s missense polymerase mutation in the polymerase, conferring temperature sensitivity.A single intranasal dose of RSV/6120/ΔNS2/1030s was evaluated in a double-blind, placebo-controlled trial (vaccine/placebo ratio, 2:1) at 105.7 plaque-forming units (PFU) in 15 RSV-seropositive 12-to-59-month-old children, and at 105 PFU in 30 RSV-seronegative 6-to-24-month-old children.RSV/6120/ΔNS2/1030s infected 100% of RSV-seronegative vaccinees and was immunogenic (geometric mean RSV plaque-reduction neutralizing antibody titer [RSV-PRNT], 1:91) and genetically stable. Mild rhinorrhea was detected more frequently in vaccinees (18/20 V vs 4/10 P, p=0.007), and LRI occurred in 1 vaccinee during a period when only vaccine virus was detected. Following the RSV season, 5/16 vaccinees had ≥4-fold rises in RSV-PRNT with significantly higher titers than 4/10 placebo recipients with rises (1:1992 vs. 1:274, P=0.02). Thus, RSV/6120/ΔNS2/1030s primed for substantial anamnestic neutralizing antibody responses following naturally-acquired RSV infection.RSV/6120/ΔNS2/1030s is immunogenic and genetically stable in RSV-seronegative children, but the frequency of rhinorrhea in vaccinees exceeded that in placebo recipients.A live-attenuated intranasal respiratory syncytial virus vaccine candidate containing a deletion of the interferon antagonist NS2 gene and a genetically stabilized temperature-sensitivity mutation in the polymerase gene was infectious and induced primary neutralizing serum antibody responses and potent memory antibody responses in 6-to-24 month-old RSV-seronegative children, but may be associated with rhinorrhea." @default.
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- W4385263910 date "2023-07-26" @default.
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- W4385263910 title "Evaluation of the live-attenuated intranasal respiratory syncytial virus (RSV) vaccine RSV/6120/ΔNS2/1030s in RSV-seronegative young children" @default.
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- W4385263910 doi "https://doi.org/10.1093/infdis/jiad281" @default.
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