FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385264964> ?p ?o ?g. }

• W4385264964 abstract "Objectives Cyclic thrombocytopenia (CTP) is a rare blood disorder characterized by periodic fluctuations in platelet counts. CTP usually appears in pre-menopausal women, and these fluctuations of platelets are in phase with the menstrual cycle. CTP is a heterogeneous disease, and the pathogenic mechanism is still unclear. Therefore, it harbors great significance for exploring the association of fluctuations in platelet counts with hormonal-cycle.Materials Firstly, we washed human platelets from healthy volunteers following the Declaration of Helsinki. Flow cytometer was employed to measure the mitochondrial inner transmembrane potential (ΔΨm) depolarization, PS exposure, P-selectin expression, and GPIIb/IIIa activation in platelets. In addition, western blot detected the related protein expression. The corresponding assay kit measured the caspase-3 and PDE3A activity. Finally, flow cytometry determined mouse platelets labeled with calcein.Results We find a reverse relationship between the platelet count and serum estradiol (E2) level in a CTP patient. We demonstrated that E2 induces platelet apoptosis in vitro and platelet clearance in vivo. We further discovered that E2 activates phosphodiesterase 3A, which inhibits protein kinase A (PKA), leading to PKA-mediated platelet apoptosis. Activation of PKA protected platelets from E2-induced thrombocytopenia and elevated the number of mice circulatory platelets.Conclusions We find that E2 induces platelet apoptosis and clearance through PDE3A-mediated PKA inhibition. Activation of PKA rescues E2-induced thrombocytopenia in mice. Thus, our study reveals a pathogenesis of E2-related CTP and suggests promising therapeutic strategies for the disease." @default.
• W4385264964 created "2023-07-27" @default.
• W4385264964 creator A5007923079 @default.
• W4385264964 creator A5010417792 @default.
• W4385264964 creator A5021523686 @default.
• W4385264964 creator A5021527861 @default.
• W4385264964 creator A5024894780 @default.
• W4385264964 creator A5041634479 @default.
• W4385264964 creator A5041974577 @default.
• W4385264964 creator A5065379432 @default.
• W4385264964 creator A5065433951 @default.
• W4385264964 creator A5089182592 @default.
• W4385264964 date "2023-07-26" @default.
• W4385264964 modified "2023-09-25" @default.
• W4385264964 title "Cyclic thrombocytopenia associated with estradiol: a case report" @default.
• W4385264964 cites W1491050497 @default.
• W4385264964 cites W1972522441 @default.
• W4385264964 cites W1979543372 @default.
• W4385264964 cites W1984316467 @default.
• W4385264964 cites W2006447143 @default.
• W4385264964 cites W2014696850 @default.
• W4385264964 cites W2018409696 @default.
• W4385264964 cites W2033613592 @default.
• W4385264964 cites W2043753012 @default.
• W4385264964 cites W2056188247 @default.
• W4385264964 cites W2078577723 @default.
• W4385264964 cites W2086075884 @default.
• W4385264964 cites W2150917674 @default.
• W4385264964 cites W2151713766 @default.
• W4385264964 cites W2161241686 @default.
• W4385264964 cites W2313464247 @default.
• W4385264964 cites W2469420359 @default.
• W4385264964 cites W2469455038 @default.
• W4385264964 cites W2766331338 @default.
• W4385264964 cites W2807575667 @default.
• W4385264964 cites W2897195419 @default.
• W4385264964 cites W2969107945 @default.
• W4385264964 cites W3045706461 @default.
• W4385264964 cites W3105519109 @default.
• W4385264964 doi "https://doi.org/10.1080/16078454.2023.2240140" @default.
• W4385264964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37493411" @default.
• W4385264964 hasPublicationYear "2023" @default.
• W4385264964 type Work @default.
• W4385264964 citedByCount "0" @default.
• W4385264964 crossrefType "journal-article" @default.
• W4385264964 hasAuthorship W4385264964A5007923079 @default.
• W4385264964 hasAuthorship W4385264964A5010417792 @default.
• W4385264964 hasAuthorship W4385264964A5021523686 @default.
• W4385264964 hasAuthorship W4385264964A5021527861 @default.
• W4385264964 hasAuthorship W4385264964A5024894780 @default.
• W4385264964 hasAuthorship W4385264964A5041634479 @default.
• W4385264964 hasAuthorship W4385264964A5041974577 @default.
• W4385264964 hasAuthorship W4385264964A5065379432 @default.
• W4385264964 hasAuthorship W4385264964A5065433951 @default.
• W4385264964 hasAuthorship W4385264964A5089182592 @default.
• W4385264964 hasBestOaLocation W43852649641 @default.
• W4385264964 hasConcept C104317684 @default.
• W4385264964 hasConcept C126322002 @default.
• W4385264964 hasConcept C134018914 @default.
• W4385264964 hasConcept C150903083 @default.
• W4385264964 hasConcept C185592680 @default.
• W4385264964 hasConcept C190283241 @default.
• W4385264964 hasConcept C203014093 @default.
• W4385264964 hasConcept C207001950 @default.
• W4385264964 hasConcept C2776415932 @default.
• W4385264964 hasConcept C2780942790 @default.
• W4385264964 hasConcept C3018697912 @default.
• W4385264964 hasConcept C553184892 @default.
• W4385264964 hasConcept C55493867 @default.
• W4385264964 hasConcept C71924100 @default.
• W4385264964 hasConcept C86803240 @default.
• W4385264964 hasConcept C89560881 @default.
• W4385264964 hasConceptScore W4385264964C104317684 @default.
• W4385264964 hasConceptScore W4385264964C126322002 @default.
• W4385264964 hasConceptScore W4385264964C134018914 @default.
• W4385264964 hasConceptScore W4385264964C150903083 @default.
• W4385264964 hasConceptScore W4385264964C185592680 @default.
• W4385264964 hasConceptScore W4385264964C190283241 @default.
• W4385264964 hasConceptScore W4385264964C203014093 @default.
• W4385264964 hasConceptScore W4385264964C207001950 @default.
• W4385264964 hasConceptScore W4385264964C2776415932 @default.
• W4385264964 hasConceptScore W4385264964C2780942790 @default.
• W4385264964 hasConceptScore W4385264964C3018697912 @default.
• W4385264964 hasConceptScore W4385264964C553184892 @default.
• W4385264964 hasConceptScore W4385264964C55493867 @default.
• W4385264964 hasConceptScore W4385264964C71924100 @default.
• W4385264964 hasConceptScore W4385264964C86803240 @default.
• W4385264964 hasConceptScore W4385264964C89560881 @default.
• W4385264964 hasFunder F4320321001 @default.
• W4385264964 hasFunder F4320327518 @default.
• W4385264964 hasIssue "1" @default.
• W4385264964 hasLocation W43852649641 @default.
• W4385264964 hasLocation W43852649642 @default.
• W4385264964 hasOpenAccess W4385264964 @default.
• W4385264964 hasPrimaryLocation W43852649641 @default.
• W4385264964 hasRelatedWork W1615966168 @default.
• W4385264964 hasRelatedWork W1940255321 @default.
• W4385264964 hasRelatedWork W2073408300 @default.
• W4385264964 hasRelatedWork W2107947912 @default.
• W4385264964 hasRelatedWork W2253642286 @default.

• next