FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385266380> ?p ?o ?g. }

• W4385266380 endingPage "371" @default.
• W4385266380 startingPage "367" @default.
• W4385266380 abstract "Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients were excluded from the initial SARS-CoV-2 mRNA vaccination efficacy trials. Suboptimal vaccine responses have been reported in immunocompromised cohorts such as patients with solid tumors or hematologic malignancies, suggesting the need for additional research. Widespread data on the antibody responses and vaccine efficacy in allo-HSCT recipients is limited. In our single-center, retrospective study, we analyzed the anti-spike IgG antibody responses in 75 allo-HSCT recipients who received a series of two doses of mRNA vaccination. We collected data on previous COVID-19 infection, B and T lymphocyte recovery, donor types, graft-vs.-host disease (GVHD), and immunosuppressive medications at the time of vaccination. With the original variant, a cutoff of 4,160 arbitrary units (AU)/mL has been correlated with a 0.95 probability of a viral neutralization. We also examined the number of allo-HSCT recipients who achieved this conservative threshold. To our knowledge, no correlate exists for the currently prevalent Omicron variant and viral neutralization. Despite 29.3% (22/75) of patients being on systemic immunosuppressive medications due to chronic GVHD, positive antibody responses > 50 AU/mL were seen in 96% of patients. However, only 48% (36/75) of patients were above the neutralizing antibody threshold. Those with previous COVID-19 infection had significantly higher antibody responses. Although encouraging, the variability of the responses underscores the concept of ongoing antibody monitoring as well as consideration of additional doses of the COVID-19 vaccine in this cohort." @default.
• W4385266380 created "2023-07-27" @default.
• W4385266380 creator A5067973814 @default.
• W4385266380 creator A5084302167 @default.
• W4385266380 creator A5089074892 @default.
• W4385266380 creator A5090985347 @default.
• W4385266380 creator A5092544696 @default.
• W4385266380 date "2023-07-01" @default.
• W4385266380 modified "2023-09-23" @default.
• W4385266380 title "Anti-Spike Antibody Responses in Allogeneic Stem Cell Transplant Recipients to Two Doses of COVID-19 mRNA Vaccination: A Retrospective, Single-Center Analysis" @default.
• W4385266380 cites W3092986206 @default.
• W4385266380 cites W3111255098 @default.
• W4385266380 cites W3143959537 @default.
• W4385266380 cites W3146894320 @default.
• W4385266380 cites W3158948419 @default.
• W4385266380 cites W3173150656 @default.
• W4385266380 cites W3177832759 @default.
• W4385266380 cites W3180610917 @default.
• W4385266380 cites W3202877243 @default.
• W4385266380 cites W3208594704 @default.
• W4385266380 cites W4206670653 @default.
• W4385266380 doi "https://doi.org/10.6004/jadpro.2023.14.5.2" @default.
• W4385266380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37576365" @default.
• W4385266380 hasPublicationYear "2023" @default.
• W4385266380 type Work @default.
• W4385266380 citedByCount "0" @default.
• W4385266380 crossrefType "journal-article" @default.
• W4385266380 hasAuthorship W4385266380A5067973814 @default.
• W4385266380 hasAuthorship W4385266380A5084302167 @default.
• W4385266380 hasAuthorship W4385266380A5089074892 @default.
• W4385266380 hasAuthorship W4385266380A5090985347 @default.
• W4385266380 hasAuthorship W4385266380A5092544696 @default.
• W4385266380 hasConcept C126322002 @default.
• W4385266380 hasConcept C159047783 @default.
• W4385266380 hasConcept C159654299 @default.
• W4385266380 hasConcept C203014093 @default.
• W4385266380 hasConcept C22070199 @default.
• W4385266380 hasConcept C2777408962 @default.
• W4385266380 hasConcept C2911091166 @default.
• W4385266380 hasConcept C71924100 @default.
• W4385266380 hasConceptScore W4385266380C126322002 @default.
• W4385266380 hasConceptScore W4385266380C159047783 @default.
• W4385266380 hasConceptScore W4385266380C159654299 @default.
• W4385266380 hasConceptScore W4385266380C203014093 @default.
• W4385266380 hasConceptScore W4385266380C22070199 @default.
• W4385266380 hasConceptScore W4385266380C2777408962 @default.
• W4385266380 hasConceptScore W4385266380C2911091166 @default.
• W4385266380 hasConceptScore W4385266380C71924100 @default.
• W4385266380 hasIssue "5" @default.
• W4385266380 hasLocation W43852663801 @default.
• W4385266380 hasLocation W43852663802 @default.
• W4385266380 hasOpenAccess W4385266380 @default.
• W4385266380 hasPrimaryLocation W43852663801 @default.
• W4385266380 hasRelatedWork W1977724887 @default.
• W4385266380 hasRelatedWork W1984647379 @default.
• W4385266380 hasRelatedWork W2029074520 @default.
• W4385266380 hasRelatedWork W2084505320 @default.
• W4385266380 hasRelatedWork W2089394918 @default.
• W4385266380 hasRelatedWork W2108106476 @default.
• W4385266380 hasRelatedWork W2163895276 @default.
• W4385266380 hasRelatedWork W2729974503 @default.
• W4385266380 hasRelatedWork W4319815297 @default.
• W4385266380 hasRelatedWork W2181940165 @default.
• W4385266380 hasVolume "14" @default.
• W4385266380 isParatext "false" @default.
• W4385266380 isRetracted "false" @default.
• W4385266380 workType "article" @default.