Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385267046> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4385267046 endingPage "106756" @default.
- W4385267046 startingPage "106756" @default.
- W4385267046 abstract "Surface defects and the ability to tune the physicochemical properties of zirconium oxide nanoparticles (ZrO2 NPs) have made them a hot topic in biological research. We investigated the anticancer properties of Acacia nilotica (L.) fruit extract–green produced ZrO2/RGO nanocomposites (NCs). Fruit extract's polyphenolic and flavonoid compounds served as reducing and capping agents for the creation of ZrO2 adorned RGO sheets. Our goal was to maximize the anticancer potential of ZrO2/RGO NCs while simultaneously reducing their toxicity to normal tissues and reducing their impact on the environment. The XPS, XRD, TEM, SEM, EDS, and PL were used to characterize the pure ZrO2 NPs and ZrO2/RGO NCs that were green produced. XRD analysis revealed that ZrO2 crystallized in two different phases, monoclinic and tetragonal. TEM and SEM images demonstrated that ZrO2 particles were uniformly attached on RGO sheets. XPS and EDX analysis of the produced NCs verified the presence of ZrO2 and RGO. ZrO2 NPs had their particle size and PL intensity decreased after RGO addition. Anticancer data shown that ZrO2/RGO NCs was two-times more effective than pure ZrO2 NPs in inhibiting the growth of different human cancer cells (A549, HepG2, and MCF7). Mechanistic evidence revealed that intracellular reactive oxygen species production and glutathione reduction constituted oxidative stress that caused the anticancer response of ZrO2/RGO NCs. Apoptosis is also suggested by the decrease of mitochondrial membrane potential in cancer cells after they have been exposed to as produced NCs. In addition, when compared to pure ZrO2 NPs, ZrO2/RGO NCs showed greater cytocompatibility in normal cell lines (IMR90 and MCF10A). This innovative method highlights the significance of plant-based synthesis of nanocomposites for biomedical research as being both environmentally benign and low-cost." @default.
- W4385267046 created "2023-07-27" @default.
- W4385267046 creator A5065675626 @default.
- W4385267046 creator A5077154705 @default.
- W4385267046 creator A5079407571 @default.
- W4385267046 date "2023-08-01" @default.
- W4385267046 modified "2023-09-27" @default.
- W4385267046 title "ZrO2 nanoparticles anchored on RGO sheets: Eco-friendly synthesis from Acacia nilotica (L.) fruit extract, characterization, and enhanced anticancer activity in different human cancer cells" @default.
- W4385267046 cites W1979016230 @default.
- W4385267046 cites W1980146229 @default.
- W4385267046 cites W2006370393 @default.
- W4385267046 cites W2114918609 @default.
- W4385267046 cites W2163980958 @default.
- W4385267046 cites W2259682376 @default.
- W4385267046 cites W2589813568 @default.
- W4385267046 cites W2594654629 @default.
- W4385267046 cites W2604637006 @default.
- W4385267046 cites W2749137635 @default.
- W4385267046 cites W2773390998 @default.
- W4385267046 cites W2792726055 @default.
- W4385267046 cites W2883202795 @default.
- W4385267046 cites W2899246795 @default.
- W4385267046 cites W2912156312 @default.
- W4385267046 cites W2966264773 @default.
- W4385267046 cites W2984180404 @default.
- W4385267046 cites W3005689864 @default.
- W4385267046 cites W3042921753 @default.
- W4385267046 cites W3049317096 @default.
- W4385267046 cites W3128646645 @default.
- W4385267046 cites W3157045718 @default.
- W4385267046 cites W3173551231 @default.
- W4385267046 cites W4221024350 @default.
- W4385267046 cites W4312174135 @default.
- W4385267046 cites W4315485575 @default.
- W4385267046 cites W947820935 @default.
- W4385267046 doi "https://doi.org/10.1016/j.mtcomm.2023.106756" @default.
- W4385267046 hasPublicationYear "2023" @default.
- W4385267046 type Work @default.
- W4385267046 citedByCount "0" @default.
- W4385267046 crossrefType "journal-article" @default.
- W4385267046 hasAuthorship W4385267046A5065675626 @default.
- W4385267046 hasAuthorship W4385267046A5077154705 @default.
- W4385267046 hasAuthorship W4385267046A5079407571 @default.
- W4385267046 hasConcept C127413603 @default.
- W4385267046 hasConcept C13965031 @default.
- W4385267046 hasConcept C155672457 @default.
- W4385267046 hasConcept C171250308 @default.
- W4385267046 hasConcept C175708663 @default.
- W4385267046 hasConcept C185592680 @default.
- W4385267046 hasConcept C192562407 @default.
- W4385267046 hasConcept C42360764 @default.
- W4385267046 hasConcept C48349386 @default.
- W4385267046 hasConcept C55493867 @default.
- W4385267046 hasConceptScore W4385267046C127413603 @default.
- W4385267046 hasConceptScore W4385267046C13965031 @default.
- W4385267046 hasConceptScore W4385267046C155672457 @default.
- W4385267046 hasConceptScore W4385267046C171250308 @default.
- W4385267046 hasConceptScore W4385267046C175708663 @default.
- W4385267046 hasConceptScore W4385267046C185592680 @default.
- W4385267046 hasConceptScore W4385267046C192562407 @default.
- W4385267046 hasConceptScore W4385267046C42360764 @default.
- W4385267046 hasConceptScore W4385267046C48349386 @default.
- W4385267046 hasConceptScore W4385267046C55493867 @default.
- W4385267046 hasFunder F4320321145 @default.
- W4385267046 hasFunder F4320327296 @default.
- W4385267046 hasLocation W43852670461 @default.
- W4385267046 hasOpenAccess W4385267046 @default.
- W4385267046 hasPrimaryLocation W43852670461 @default.
- W4385267046 hasRelatedWork W1188655835 @default.
- W4385267046 hasRelatedWork W1978635052 @default.
- W4385267046 hasRelatedWork W2008512679 @default.
- W4385267046 hasRelatedWork W2058168604 @default.
- W4385267046 hasRelatedWork W2075643564 @default.
- W4385267046 hasRelatedWork W2089472998 @default.
- W4385267046 hasRelatedWork W2148300587 @default.
- W4385267046 hasRelatedWork W2392903152 @default.
- W4385267046 hasRelatedWork W2783992498 @default.
- W4385267046 hasRelatedWork W3122247451 @default.
- W4385267046 hasVolume "36" @default.
- W4385267046 isParatext "false" @default.
- W4385267046 isRetracted "false" @default.
- W4385267046 workType "article" @default.