FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385267060> ?p ?o ?g. }

• W4385267060 endingPage "129" @default.
• W4385267060 startingPage "118" @default.
• W4385267060 abstract "The liver is a highly vascularized organ where fluid properties, including vascular pressure, vessel integrity and fluid viscosity, play a critical role in gross mechanical properties. To study the effects of portal pressure, liver confinement, fluid viscosity, and tissue crosslinking on liver stiffness, water diffusion, and vessel size, we applied multiparametric magnetic resonance imaging (mpMRI), including multifrequency magnetic resonance elastography (MRE) and apparent diffusion coefficient (ADC) measurements, to ex vivo livers from healthy male rats (13.6±1.6 weeks) at room temperature. Four scenarios including altered liver confinement, tissue crosslinking, and vascular fluid viscosity were investigated with mpMRI at different portal pressure levels (0-17.5 cmH2O). Our experiments demonstrated that, with increasing portal pressure, rat livers showed higher water content, water diffusivity, and increased vessel sizes quantified by the vessel tissue volume fraction (VTVF). These effects were most pronounced in native, unconfined livers (VTVF: 300±120%, p<0.05, ADC: 88±29%, p<0.01), while still significant under confinement (confined: VTVF: 53±32%, p<0.01, ADC: 28±19%, p<0.05; confined-fixed: VTVF: 52±20%, p<0.001, ADC: 11±2%, p<0.01; confined-viscous: VTVF: 210±110%, p<0.01, ADC: 26±9%, p<0.001). Softening with elevated portal pressure (-12±5, p<0.05) occurred regardless of confinement and fixation. However, the liver stiffened when exposed to a more viscous inflow fluid (11±4%, p<0.001). Taken together, our results elucidate the complex relationship between macroscopic-biophysical parameters of liver tissue measured by mpMRI and vascular-fluid properties. Influenced by portal pressure, vascular permeability, and matrix crosslinking, liver stiffness is sensitive to intrinsic poroelastic properties, which, alongside vascular architecture and water diffusivity, may aid in the differential diagnosis of liver disease. STATEMENT OF SIGNIFICANCE: Using highly controllable ex vivo rat liver phantoms, hepatic biophysical properties such as tissue-vascular structure, stiffness, and water diffusivity were investigated using multiparametric MRI including multifrequency magnetic resonance elastography (MRE) and diffusion-weighted imaging (DWI). Through elaborate tuning of the experimental conditions such as the static portal pressure, flow viscosity, amount and distribution of fluid content in the liver, we identified the contributions of the fluid component to the overall imaging-based biophysical properties of the liver. Our finding demonstrated the sensitivity of liver stiffness to the hepatic poroelastic properties, which may aid in the differential diagnosis of liver diseases." @default.
• W4385267060 created "2023-07-27" @default.
• W4385267060 creator A5020423205 @default.
• W4385267060 creator A5020825939 @default.
• W4385267060 creator A5028416192 @default.
• W4385267060 creator A5054000154 @default.
• W4385267060 creator A5054594576 @default.
• W4385267060 creator A5059891669 @default.
• W4385267060 creator A5066508060 @default.
• W4385267060 creator A5068391541 @default.
• W4385267060 creator A5077033598 @default.
• W4385267060 creator A5092481599 @default.
• W4385267060 creator A5092544782 @default.
• W4385267060 date "2023-10-01" @default.
• W4385267060 modified "2023-10-17" @default.
• W4385267060 title "The influence of static portal pressure on liver biophysical properties" @default.
• W4385267060 cites W1534200373 @default.
• W4385267060 cites W1743388696 @default.
• W4385267060 cites W1970349598 @default.
• W4385267060 cites W1972683398 @default.
• W4385267060 cites W1975239399 @default.
• W4385267060 cites W1989986382 @default.
• W4385267060 cites W1990108161 @default.
• W4385267060 cites W2001101442 @default.
• W4385267060 cites W2018460596 @default.
• W4385267060 cites W2022305236 @default.
• W4385267060 cites W2026101575 @default.
• W4385267060 cites W2046286590 @default.
• W4385267060 cites W2050516721 @default.
• W4385267060 cites W2053619386 @default.
• W4385267060 cites W2059700429 @default.
• W4385267060 cites W2064306873 @default.
• W4385267060 cites W2065295372 @default.
• W4385267060 cites W2066210090 @default.
• W4385267060 cites W2081192448 @default.
• W4385267060 cites W2081814295 @default.
• W4385267060 cites W2084690382 @default.
• W4385267060 cites W2117913805 @default.
• W4385267060 cites W2126598675 @default.
• W4385267060 cites W2127890285 @default.
• W4385267060 cites W2128082929 @default.
• W4385267060 cites W2133287637 @default.
• W4385267060 cites W2153147895 @default.
• W4385267060 cites W2162020807 @default.
• W4385267060 cites W2162093412 @default.
• W4385267060 cites W2166859770 @default.
• W4385267060 cites W2224540085 @default.
• W4385267060 cites W2235312129 @default.
• W4385267060 cites W2295059921 @default.
• W4385267060 cites W2413105307 @default.
• W4385267060 cites W2415567229 @default.
• W4385267060 cites W2505054645 @default.
• W4385267060 cites W255705006 @default.
• W4385267060 cites W2582061175 @default.
• W4385267060 cites W2808200121 @default.
• W4385267060 cites W2926231278 @default.
• W4385267060 cites W2943988456 @default.
• W4385267060 cites W2965482092 @default.
• W4385267060 cites W2965817008 @default.
• W4385267060 cites W2965908777 @default.
• W4385267060 cites W2969330268 @default.
• W4385267060 cites W2985965063 @default.
• W4385267060 cites W3001608230 @default.
• W4385267060 cites W3005995304 @default.
• W4385267060 cites W3033292568 @default.
• W4385267060 cites W3086034025 @default.
• W4385267060 cites W3090233960 @default.
• W4385267060 cites W3095911100 @default.
• W4385267060 cites W3109577455 @default.
• W4385267060 cites W3112080032 @default.
• W4385267060 cites W3163810364 @default.
• W4385267060 cites W3177081266 @default.
• W4385267060 cites W3187810090 @default.
• W4385267060 cites W3202269521 @default.
• W4385267060 cites W3204369737 @default.
• W4385267060 cites W4229077816 @default.
• W4385267060 cites W4281637617 @default.
• W4385267060 cites W4295048107 @default.
• W4385267060 doi "https://doi.org/10.1016/j.actbio.2023.07.033" @default.
• W4385267060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37507032" @default.
• W4385267060 hasPublicationYear "2023" @default.
• W4385267060 type Work @default.
• W4385267060 citedByCount "0" @default.
• W4385267060 crossrefType "journal-article" @default.
• W4385267060 hasAuthorship W4385267060A5020423205 @default.
• W4385267060 hasAuthorship W4385267060A5020825939 @default.
• W4385267060 hasAuthorship W4385267060A5028416192 @default.
• W4385267060 hasAuthorship W4385267060A5054000154 @default.
• W4385267060 hasAuthorship W4385267060A5054594576 @default.
• W4385267060 hasAuthorship W4385267060A5059891669 @default.
• W4385267060 hasAuthorship W4385267060A5066508060 @default.
• W4385267060 hasAuthorship W4385267060A5068391541 @default.
• W4385267060 hasAuthorship W4385267060A5077033598 @default.
• W4385267060 hasAuthorship W4385267060A5092481599 @default.
• W4385267060 hasAuthorship W4385267060A5092544782 @default.
• W4385267060 hasConcept C121332964 @default.
• W4385267060 hasConcept C126322002 @default.
• W4385267060 hasConcept C126838900 @default.

• next