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- W4385269882 abstract "Autophagy, a programmed cell-lysis mechanism, holds significant promise in the prevention and treatment of a wide range of conditions, including cancer, Alzheimer's, and Parkinson's disease. The successful utilization of autophagy modulation for therapeutic purposes hinges upon accurately determining the role of autophagy in disease progression, whether it acts as a cytotoxic or cytoprotective factor. This critical knowledge empowers scientists to effectively manipulate tumor sensitivity to anti-cancer therapies through autophagy modulation, while also circumventing drug resistance. However, conventional therapies face limitations such as low bioavailability, poor solubility, and a lack of controlled release mechanisms, hindering their clinical applicability. In this regard, innovative nanoplatforms including organic and inorganic systems have emerged as promising solutions to offer stimuli-responsive, theranostic-controlled drug delivery systems with active targeting and improved solubility. The review article explores a variety of organic nanoplatforms, such as lipid-based, polymer-based, and DNA-based systems, which incorporate autophagy-inhibiting drugs like hydroxychloroquine. By inhibiting the glycolytic pathway and depriving cells of essential nutrients, these platforms exhibit tumor-suppressive effects in advanced forms of cancer such as leukemia, colon cancer, and glioblastoma. Furthermore, metal-based, metal-oxide-based, silica-based, and quantum dot-based nanoplatforms selectively induce autophagy in tumors, leading to extensive cancer cell destruction. Additionally, this article discusses the current clinical status of autophagy-modulating drugs for cancer therapy with valuable insights of progress and potential of such approaches." @default.
- W4385269882 created "2023-07-27" @default.
- W4385269882 creator A5049946223 @default.
- W4385269882 creator A5052157244 @default.
- W4385269882 date "2023-10-01" @default.
- W4385269882 modified "2023-10-17" @default.
- W4385269882 title "Dual role of autophagy for advancements from conventional to new delivery systems in cancer" @default.
- W4385269882 cites W1864635191 @default.
- W4385269882 cites W1967369724 @default.
- W4385269882 cites W1973863994 @default.
- W4385269882 cites W1980836878 @default.
- W4385269882 cites W1981140858 @default.
- W4385269882 cites W1983275934 @default.
- W4385269882 cites W1985124617 @default.
- W4385269882 cites W1987223105 @default.
- W4385269882 cites W1996593753 @default.
- W4385269882 cites W1997703672 @default.
- W4385269882 cites W2013544053 @default.
- W4385269882 cites W2019763279 @default.
- W4385269882 cites W2021492060 @default.
- W4385269882 cites W2025665129 @default.
- W4385269882 cites W2026343450 @default.
- W4385269882 cites W2030614165 @default.
- W4385269882 cites W2036149332 @default.
- W4385269882 cites W2040818294 @default.
- W4385269882 cites W2048260467 @default.
- W4385269882 cites W2052746044 @default.
- W4385269882 cites W2054869940 @default.
- W4385269882 cites W2059210685 @default.
- W4385269882 cites W2073593079 @default.
- W4385269882 cites W2074900534 @default.
- W4385269882 cites W2078893058 @default.
- W4385269882 cites W2080637633 @default.
- W4385269882 cites W2082306065 @default.
- W4385269882 cites W2082908153 @default.
- W4385269882 cites W2089074573 @default.
- W4385269882 cites W2098264151 @default.
- W4385269882 cites W2100434800 @default.
- W4385269882 cites W2105114667 @default.
- W4385269882 cites W2106255061 @default.
- W4385269882 cites W2107499423 @default.
- W4385269882 cites W2117695104 @default.
- W4385269882 cites W2120487347 @default.
- W4385269882 cites W2130476291 @default.
- W4385269882 cites W2134696790 @default.
- W4385269882 cites W2137335948 @default.
- W4385269882 cites W2146729192 @default.
- W4385269882 cites W2147058114 @default.
- W4385269882 cites W2152541437 @default.
- W4385269882 cites W2159737816 @default.
- W4385269882 cites W2170632276 @default.
- W4385269882 cites W2215852242 @default.
- W4385269882 cites W2319754980 @default.
- W4385269882 cites W2327752102 @default.
- W4385269882 cites W2344598639 @default.
- W4385269882 cites W2382201896 @default.
- W4385269882 cites W2416965075 @default.
- W4385269882 cites W2501387124 @default.
- W4385269882 cites W2514431030 @default.
- W4385269882 cites W2517175971 @default.
- W4385269882 cites W2519809863 @default.
- W4385269882 cites W2528400159 @default.
- W4385269882 cites W2529118875 @default.
- W4385269882 cites W2547933649 @default.
- W4385269882 cites W2551070279 @default.
- W4385269882 cites W2557398898 @default.
- W4385269882 cites W2589680618 @default.
- W4385269882 cites W2597588035 @default.
- W4385269882 cites W2598439575 @default.
- W4385269882 cites W2614361121 @default.
- W4385269882 cites W2615095363 @default.
- W4385269882 cites W2625470034 @default.
- W4385269882 cites W2737499383 @default.
- W4385269882 cites W2740618823 @default.
- W4385269882 cites W2745590142 @default.
- W4385269882 cites W2752925838 @default.
- W4385269882 cites W2753932015 @default.
- W4385269882 cites W2755560018 @default.
- W4385269882 cites W2768828610 @default.
- W4385269882 cites W2773997761 @default.
- W4385269882 cites W2782049437 @default.
- W4385269882 cites W2790008889 @default.
- W4385269882 cites W2795845448 @default.
- W4385269882 cites W2800819803 @default.
- W4385269882 cites W2806101189 @default.
- W4385269882 cites W2811197042 @default.
- W4385269882 cites W2883158359 @default.
- W4385269882 cites W2885457344 @default.
- W4385269882 cites W2889039154 @default.
- W4385269882 cites W2889094617 @default.
- W4385269882 cites W2889179116 @default.
- W4385269882 cites W2890347012 @default.
- W4385269882 cites W2890370082 @default.
- W4385269882 cites W2894600652 @default.
- W4385269882 cites W2901451181 @default.
- W4385269882 cites W2913162255 @default.
- W4385269882 cites W2913389688 @default.
- W4385269882 cites W2921773418 @default.