FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385272105> ?p ?o ?g. }

• W4385272105 abstract "Introduction Higher frequencies of mucosal-associated invariant T (MAIT) cells were associated with an increased adaptive response to mRNA BNT162b2 SARS-CoV-2 vaccine, however, the mechanistic insights into this relationship are unknown. In the present study, we hypothesized that the TNF response of MAIT cells supports B cell activation following SARS-CoV-2 immunization. Methods To investigate the effects of repeated SARS-CoV-2 vaccinations on the peripheral blood mononuclear cells (PBMCs), we performed a longitudinal single cell (sc)RNA-seq and scTCR-seq analysis of SARS-CoV-2 vaccinated healthy adults with two doses of the Pfizer-BioNTech BNT162b2 mRNA vaccine. Collection of PBMCs was performed 1 day before, 3 and 17 days after prime vaccination, and 3 days and 3 months following vaccine boost. Based on scRNA/TCR-seq data related to regulatory signals induced by the vaccine, we used computational approaches for the functional pathway enrichment analysis (Reactome), dynamics of the effector cell-polarization (RNA Velocity and CellRank), and cell-cell communication (NicheNet). Results We identified MAIT cells as an important source of TNF across circulating lymphocytes in response to repeated SARS-CoV-2 BNT162b2 vaccination. The TNF high signature of MAIT cells was induced by the second administration of the vaccine. Notably, the increased TNF expression was associated with MAIT cell proliferation and efficient anti-SARS-CoV-2 antibody production. Finally, by decoding the ligand-receptor interactions and incorporating intracellular signaling, we predicted TNF high MAIT cell interplay with different B cell subsets. In specific, predicted TNF -mediated activation was selectively directed to conventional switched memory B cells, which are deputed to high-affinity long-term memory. Discussion Overall, our results indicate that SARS-CoV-2 BNT162b2 vaccination influences MAIT cell frequencies and their transcriptional effector profile with the potential to promote B cell activation. This research also provides a blueprint for the promising use of MAIT cells as cellular adjuvants in mRNA-based vaccines." @default.
• W4385272105 created "2023-07-27" @default.
• W4385272105 creator A5004744521 @default.
• W4385272105 creator A5006917294 @default.
• W4385272105 creator A5013760932 @default.
• W4385272105 creator A5018355372 @default.
• W4385272105 creator A5019213453 @default.
• W4385272105 creator A5021041745 @default.
• W4385272105 creator A5024357529 @default.
• W4385272105 creator A5032495545 @default.
• W4385272105 creator A5039614384 @default.
• W4385272105 creator A5048891781 @default.
• W4385272105 creator A5050115769 @default.
• W4385272105 creator A5054906117 @default.
• W4385272105 creator A5058497265 @default.
• W4385272105 creator A5070023574 @default.
• W4385272105 creator A5071432733 @default.
• W4385272105 creator A5072014958 @default.
• W4385272105 creator A5074394333 @default.
• W4385272105 creator A5078056183 @default.
• W4385272105 creator A5079291951 @default.
• W4385272105 creator A5083703894 @default.
• W4385272105 creator A5089437312 @default.
• W4385272105 date "2023-07-26" @default.
• W4385272105 modified "2023-10-10" @default.
• W4385272105 title "Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination" @default.
• W4385272105 cites W1538607209 @default.
• W4385272105 cites W1554262276 @default.
• W4385272105 cites W1919305622 @default.
• W4385272105 cites W1936097758 @default.
• W4385272105 cites W2001802780 @default.
• W4385272105 cites W2011125600 @default.
• W4385272105 cites W2027160668 @default.
• W4385272105 cites W2030817385 @default.
• W4385272105 cites W2048285204 @default.
• W4385272105 cites W2050633514 @default.
• W4385272105 cites W2065252029 @default.
• W4385272105 cites W2068487285 @default.
• W4385272105 cites W2073247934 @default.
• W4385272105 cites W2076524314 @default.
• W4385272105 cites W2083945266 @default.
• W4385272105 cites W2143709477 @default.
• W4385272105 cites W2144152742 @default.
• W4385272105 cites W2147022432 @default.
• W4385272105 cites W2147587800 @default.
• W4385272105 cites W2298207105 @default.
• W4385272105 cites W2313070720 @default.
• W4385272105 cites W2343858347 @default.
• W4385272105 cites W2418540596 @default.
• W4385272105 cites W2464020216 @default.
• W4385272105 cites W2537678836 @default.
• W4385272105 cites W2596531042 @default.
• W4385272105 cites W2694141164 @default.
• W4385272105 cites W2736692372 @default.
• W4385272105 cites W2748143379 @default.
• W4385272105 cites W2766437506 @default.
• W4385272105 cites W2790170256 @default.
• W4385272105 cites W2795372657 @default.
• W4385272105 cites W2800392236 @default.
• W4385272105 cites W2886403363 @default.
• W4385272105 cites W2897114391 @default.
• W4385272105 cites W2902652978 @default.
• W4385272105 cites W2907598990 @default.
• W4385272105 cites W2967611657 @default.
• W4385272105 cites W2984472267 @default.
• W4385272105 cites W2990981263 @default.
• W4385272105 cites W2992151131 @default.
• W4385272105 cites W3000994048 @default.
• W4385272105 cites W3028985235 @default.
• W4385272105 cites W3036974859 @default.
• W4385272105 cites W3047141442 @default.
• W4385272105 cites W3094105410 @default.
• W4385272105 cites W3106188259 @default.
• W4385272105 cites W3112115390 @default.
• W4385272105 cites W3127539648 @default.
• W4385272105 cites W3127852620 @default.
• W4385272105 cites W3129676989 @default.
• W4385272105 cites W3133745688 @default.
• W4385272105 cites W3136777525 @default.
• W4385272105 cites W3137949779 @default.
• W4385272105 cites W3138177193 @default.
• W4385272105 cites W3164002891 @default.
• W4385272105 cites W3186153681 @default.
• W4385272105 cites W3188895606 @default.
• W4385272105 cites W3211135479 @default.
• W4385272105 cites W3211402536 @default.
• W4385272105 cites W3212101057 @default.
• W4385272105 cites W4200401599 @default.
• W4385272105 cites W4205496949 @default.
• W4385272105 cites W4210350488 @default.
• W4385272105 cites W4210792795 @default.
• W4385272105 cites W4223424267 @default.
• W4385272105 cites W4229016786 @default.
• W4385272105 cites W4280614268 @default.
• W4385272105 cites W4286267975 @default.
• W4385272105 cites W4288180060 @default.
• W4385272105 cites W4307488571 @default.
• W4385272105 cites W4310259000 @default.
• W4385272105 cites W4361029912 @default.
• W4385272105 doi "https://doi.org/10.3389/fimmu.2023.1208662" @default.

• next