Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385273168> ?p ?o ?g. }
- W4385273168 abstract "The functional ribosome is composed of ∼80 ribosome proteins. With the intensity-based absolute quantification (iBAQ) value, we calculate the stoichiometry ratio of each ribosome protein. We analyze the ribosome ratio-omics (Ribosome R ), which reflects the holistic signature of ribosome composition, in various biological samples with distinct functions, developmental stages, and pathological outcomes. The Ribosome R reveals significant ribosome heterogeneity among different tissues of fat, spleen, liver, kidney, heart, and skeletal muscles. During tissue development, testes at various stages of spermatogenesis show distinct Ribosome R signatures. During in vitro neuronal maturation, the Ribosome R changes reveal functional association with certain molecular aspects of neurodevelopment. Regarding ribosome heterogeneity associated with pathological conditions, the Ribosome R signature of gastric tumors is functionally linked to pathways associated with tumorigenesis. Moreover, the Ribosome R undergoes dynamic changes in macrophages following immune challenges. Taken together, with the examination of a broad spectrum of biological samples, the Ribosome R barcode reveals ribosome heterogeneity and specialization in cell function, development, and disease.Ratio-omics signature of ribosome deciphers functionally relevant heterogeneity in development and disease." @default.
- W4385273168 created "2023-07-27" @default.
- W4385273168 creator A5000936672 @default.
- W4385273168 creator A5015403864 @default.
- W4385273168 date "2023-07-25" @default.
- W4385273168 modified "2023-09-23" @default.
- W4385273168 title "Ribosome Heterogeneity in Development and Disease" @default.
- W4385273168 cites W1521601785 @default.
- W4385273168 cites W1617495083 @default.
- W4385273168 cites W1955394435 @default.
- W4385273168 cites W1975400910 @default.
- W4385273168 cites W1986219537 @default.
- W4385273168 cites W1993005351 @default.
- W4385273168 cites W2003394430 @default.
- W4385273168 cites W2018607958 @default.
- W4385273168 cites W2020574069 @default.
- W4385273168 cites W2041280565 @default.
- W4385273168 cites W2045830695 @default.
- W4385273168 cites W2048695114 @default.
- W4385273168 cites W2075477119 @default.
- W4385273168 cites W2078466987 @default.
- W4385273168 cites W2085280576 @default.
- W4385273168 cites W2119637533 @default.
- W4385273168 cites W2138419420 @default.
- W4385273168 cites W2138640452 @default.
- W4385273168 cites W2145727462 @default.
- W4385273168 cites W2151134879 @default.
- W4385273168 cites W2177551914 @default.
- W4385273168 cites W2230373379 @default.
- W4385273168 cites W2312506538 @default.
- W4385273168 cites W2313471410 @default.
- W4385273168 cites W2342962008 @default.
- W4385273168 cites W2523380436 @default.
- W4385273168 cites W2549527258 @default.
- W4385273168 cites W2605447093 @default.
- W4385273168 cites W2625763766 @default.
- W4385273168 cites W2751466210 @default.
- W4385273168 cites W2774663121 @default.
- W4385273168 cites W2783159326 @default.
- W4385273168 cites W2886956635 @default.
- W4385273168 cites W2905082999 @default.
- W4385273168 cites W2908066383 @default.
- W4385273168 cites W2914427349 @default.
- W4385273168 cites W2945765453 @default.
- W4385273168 cites W2949247954 @default.
- W4385273168 cites W2997022986 @default.
- W4385273168 cites W3008397035 @default.
- W4385273168 cites W3009491962 @default.
- W4385273168 cites W3080186743 @default.
- W4385273168 cites W3127223328 @default.
- W4385273168 cites W3130824274 @default.
- W4385273168 cites W3198338615 @default.
- W4385273168 cites W4220660062 @default.
- W4385273168 cites W4229020763 @default.
- W4385273168 cites W4235129795 @default.
- W4385273168 cites W4280578273 @default.
- W4385273168 cites W4281384542 @default.
- W4385273168 cites W4282943635 @default.
- W4385273168 cites W4283012162 @default.
- W4385273168 cites W4311472897 @default.
- W4385273168 doi "https://doi.org/10.1101/2023.07.25.550527" @default.
- W4385273168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37546733" @default.
- W4385273168 hasPublicationYear "2023" @default.
- W4385273168 type Work @default.
- W4385273168 citedByCount "0" @default.
- W4385273168 crossrefType "posted-content" @default.
- W4385273168 hasAuthorship W4385273168A5000936672 @default.
- W4385273168 hasAuthorship W4385273168A5015403864 @default.
- W4385273168 hasBestOaLocation W43852731681 @default.
- W4385273168 hasConcept C104317684 @default.
- W4385273168 hasConcept C105580179 @default.
- W4385273168 hasConcept C129194359 @default.
- W4385273168 hasConcept C149364088 @default.
- W4385273168 hasConcept C54355233 @default.
- W4385273168 hasConcept C67705224 @default.
- W4385273168 hasConcept C70721500 @default.
- W4385273168 hasConcept C86803240 @default.
- W4385273168 hasConcept C88478588 @default.
- W4385273168 hasConcept C95444343 @default.
- W4385273168 hasConceptScore W4385273168C104317684 @default.
- W4385273168 hasConceptScore W4385273168C105580179 @default.
- W4385273168 hasConceptScore W4385273168C129194359 @default.
- W4385273168 hasConceptScore W4385273168C149364088 @default.
- W4385273168 hasConceptScore W4385273168C54355233 @default.
- W4385273168 hasConceptScore W4385273168C67705224 @default.
- W4385273168 hasConceptScore W4385273168C70721500 @default.
- W4385273168 hasConceptScore W4385273168C86803240 @default.
- W4385273168 hasConceptScore W4385273168C88478588 @default.
- W4385273168 hasConceptScore W4385273168C95444343 @default.
- W4385273168 hasLocation W43852731681 @default.
- W4385273168 hasLocation W43852731682 @default.
- W4385273168 hasLocation W43852731683 @default.
- W4385273168 hasOpenAccess W4385273168 @default.
- W4385273168 hasPrimaryLocation W43852731681 @default.
- W4385273168 hasRelatedWork W1846734019 @default.
- W4385273168 hasRelatedWork W1981332340 @default.
- W4385273168 hasRelatedWork W2011940233 @default.
- W4385273168 hasRelatedWork W2028286885 @default.
- W4385273168 hasRelatedWork W2034343794 @default.
- W4385273168 hasRelatedWork W2034746322 @default.