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• W4385273316 abstract "C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single disease state. Circulating CRP levels have been monitored with a varying degree of success to gauge disease severity or to predict disease progression and outcome. Elevations in CRP level have been implicated as a useful marker to identify patients at risk for cardiovascular disease and certain cancers, and to guide therapy in a context-dependent manner. Since even strong associations do not establish causality, the pathogenic role of CRP has often been over-interpreted. CRP functions as an important modulator of host defense against bacterial infection, tissue injury and autoimmunity. CRP exists in conformationally distinct forms, which exhibit distinct functional properties and help explaining the diverse, often contradictory effects attributed to CRP. In particular, dissociation of native pentameric CRP into its subunits, monomeric CRP, unmasks hidden pro-inflammatory activities in pentameric CRP. Here, we review recent advances in CRP targeting strategies, therapeutic lowering of circulating CRP level and development of CRP antagonists, and a conformation change inhibitor in particular. We will also discuss their therapeutic potential in mitigating the deleterious actions attributed to CRP under various pathologies, including cardiovascular, pulmonary and autoimmune diseases and cancer." @default.
• W4385273316 created "2023-07-27" @default.
• W4385273316 creator A5034445592 @default.
• W4385273316 creator A5034984783 @default.
• W4385273316 creator A5038048841 @default.
• W4385273316 date "2023-07-26" @default.
• W4385273316 modified "2023-10-01" @default.
• W4385273316 title "C-reactive protein: a target for therapy to reduce inflammation" @default.
• W4385273316 cites W115717089 @default.
• W4385273316 cites W1503289876 @default.
• W4385273316 cites W1522933334 @default.
• W4385273316 cites W1585709511 @default.
• W4385273316 cites W168362195 @default.
• W4385273316 cites W1964251625 @default.
• W4385273316 cites W1968518881 @default.
• W4385273316 cites W1977588665 @default.
• W4385273316 cites W1981315894 @default.
• W4385273316 cites W1986553067 @default.
• W4385273316 cites W1997438928 @default.
• W4385273316 cites W1999264494 @default.
• W4385273316 cites W2000718683 @default.
• W4385273316 cites W2004891464 @default.
• W4385273316 cites W2005112720 @default.
• W4385273316 cites W2009660962 @default.
• W4385273316 cites W2012669470 @default.
• W4385273316 cites W2013205876 @default.
• W4385273316 cites W2018860370 @default.
• W4385273316 cites W2021895285 @default.
• W4385273316 cites W2023269495 @default.
• W4385273316 cites W2024886564 @default.
• W4385273316 cites W2026156176 @default.
• W4385273316 cites W2026281835 @default.
• W4385273316 cites W2031350146 @default.
• W4385273316 cites W2032329963 @default.
• W4385273316 cites W2034346346 @default.
• W4385273316 cites W2035765103 @default.
• W4385273316 cites W2035786177 @default.
• W4385273316 cites W2038140930 @default.
• W4385273316 cites W2048521619 @default.
• W4385273316 cites W2051471629 @default.
• W4385273316 cites W2051618926 @default.
• W4385273316 cites W2059959576 @default.
• W4385273316 cites W2062445923 @default.
• W4385273316 cites W2063572291 @default.
• W4385273316 cites W2072102752 @default.
• W4385273316 cites W2072120567 @default.
• W4385273316 cites W2072459924 @default.
• W4385273316 cites W2075578108 @default.
• W4385273316 cites W2079307913 @default.
• W4385273316 cites W2080883999 @default.
• W4385273316 cites W2083294768 @default.
• W4385273316 cites W2086898975 @default.
• W4385273316 cites W2094518321 @default.
• W4385273316 cites W2096191357 @default.
• W4385273316 cites W2097325034 @default.
• W4385273316 cites W2099964359 @default.
• W4385273316 cites W2101848486 @default.
• W4385273316 cites W2103088789 @default.
• W4385273316 cites W2104196299 @default.
• W4385273316 cites W2108688501 @default.
• W4385273316 cites W2110133619 @default.
• W4385273316 cites W2111077822 @default.
• W4385273316 cites W2111450463 @default.
• W4385273316 cites W2114047027 @default.
• W4385273316 cites W2114836455 @default.
• W4385273316 cites W2116388674 @default.
• W4385273316 cites W2122378582 @default.
• W4385273316 cites W2127101722 @default.
• W4385273316 cites W2127364218 @default.
• W4385273316 cites W2130038534 @default.
• W4385273316 cites W2132853322 @default.
• W4385273316 cites W2133942235 @default.
• W4385273316 cites W2137983259 @default.
• W4385273316 cites W2139267080 @default.
• W4385273316 cites W2144600875 @default.
• W4385273316 cites W2144896295 @default.
• W4385273316 cites W2148045758 @default.
• W4385273316 cites W2150027357 @default.
• W4385273316 cites W2150826151 @default.
• W4385273316 cites W2155110656 @default.
• W4385273316 cites W2155432457 @default.
• W4385273316 cites W2156541448 @default.
• W4385273316 cites W2156837080 @default.
• W4385273316 cites W2166910397 @default.
• W4385273316 cites W2168457321 @default.
• W4385273316 cites W2173793009 @default.
• W4385273316 cites W2275709695 @default.
• W4385273316 cites W2317184793 @default.
• W4385273316 cites W2469090867 @default.
• W4385273316 cites W2484881635 @default.
• W4385273316 cites W2581509910 @default.
• W4385273316 cites W2735696384 @default.
• W4385273316 cites W2767425013 @default.
• W4385273316 cites W2790069968 @default.
• W4385273316 cites W2805852128 @default.
• W4385273316 cites W2888261336 @default.
• W4385273316 cites W2900323763 @default.
• W4385273316 cites W2918566284 @default.
• W4385273316 cites W2918803739 @default.
• W4385273316 cites W2920558304 @default.

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