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- W4385273756 endingPage "11905" @default.
- W4385273756 startingPage "11905" @default.
- W4385273756 abstract "Diverse extracellular and intracellular cues activate mammalian mitogen-activated protein kinases (MAPKs). Canonically, the activation starts at cell surface receptors and continues via intracellular MAPK components, acting in the host cell nucleus as activators of transcriptional programs to regulate various cellular activities, including proinflammatory responses against bacterial pathogens. For instance, binding host pattern recognition receptors (PRRs) on the surface of intestinal epithelial cells to bacterial pathogen external components trigger the MAPK/NF-κB signaling cascade, eliciting cytokine production. This results in an innate immune response that can eliminate the bacterial pathogen. However, enteric bacterial pathogens evolved sophisticated mechanisms that interfere with such a response by delivering virulent proteins, termed effectors, and toxins into the host cells. These proteins act in numerous ways to inactivate or activate critical components of the MAPK signaling cascades and innate immunity. The consequence of such activities could lead to successful bacterial colonization, dissemination, and pathogenicity. This article will review enteric bacterial pathogens’ strategies to modulate MAPKs and host responses. It will also discuss findings attempting to develop anti-microbial treatments by targeting MAPKs." @default.
- W4385273756 created "2023-07-27" @default.
- W4385273756 creator A5059274484 @default.
- W4385273756 creator A5079907424 @default.
- W4385273756 date "2023-07-25" @default.
- W4385273756 modified "2023-10-14" @default.
- W4385273756 title "Mitogen-Activated Protein Kinases (MAPKs) and Enteric Bacterial Pathogens: A Complex Interplay" @default.
- W4385273756 cites W1194266616 @default.
- W4385273756 cites W1481604795 @default.
- W4385273756 cites W1497555487 @default.
- W4385273756 cites W1508362664 @default.
- W4385273756 cites W1543963511 @default.
- W4385273756 cites W1547879048 @default.
- W4385273756 cites W1549282362 @default.
- W4385273756 cites W1571593726 @default.
- W4385273756 cites W1574306778 @default.
- W4385273756 cites W1587370883 @default.
- W4385273756 cites W1599576092 @default.
- W4385273756 cites W1650840545 @default.
- W4385273756 cites W1650996792 @default.
- W4385273756 cites W1655404396 @default.
- W4385273756 cites W1824702637 @default.
- W4385273756 cites W1900006748 @default.
- W4385273756 cites W1921708445 @default.
- W4385273756 cites W1964141567 @default.
- W4385273756 cites W1965933688 @default.
- W4385273756 cites W1966178508 @default.
- W4385273756 cites W1966497951 @default.
- W4385273756 cites W1966597734 @default.
- W4385273756 cites W1967707945 @default.
- W4385273756 cites W1970121815 @default.
- W4385273756 cites W1970953122 @default.
- W4385273756 cites W1970970201 @default.
- W4385273756 cites W1971516615 @default.
- W4385273756 cites W1971811485 @default.
- W4385273756 cites W1972169896 @default.
- W4385273756 cites W1974330919 @default.
- W4385273756 cites W1974472843 @default.
- W4385273756 cites W1980940627 @default.
- W4385273756 cites W1986070597 @default.
- W4385273756 cites W1986387235 @default.
- W4385273756 cites W1986476059 @default.
- W4385273756 cites W1986753065 @default.
- W4385273756 cites W1987264412 @default.
- W4385273756 cites W1990663366 @default.
- W4385273756 cites W1991260010 @default.
- W4385273756 cites W199127835 @default.
- W4385273756 cites W1993641741 @default.
- W4385273756 cites W1995785411 @default.
- W4385273756 cites W1997648709 @default.
- W4385273756 cites W1997988662 @default.
- W4385273756 cites W2001366460 @default.
- W4385273756 cites W2001399809 @default.
- W4385273756 cites W2001758102 @default.
- W4385273756 cites W2004137182 @default.
- W4385273756 cites W2005943324 @default.
- W4385273756 cites W2009068239 @default.
- W4385273756 cites W2012162297 @default.
- W4385273756 cites W2012737807 @default.
- W4385273756 cites W2014746756 @default.
- W4385273756 cites W2019152307 @default.
- W4385273756 cites W2027493889 @default.
- W4385273756 cites W2031461397 @default.
- W4385273756 cites W2032118563 @default.
- W4385273756 cites W2033098156 @default.
- W4385273756 cites W2036606290 @default.
- W4385273756 cites W2039559526 @default.
- W4385273756 cites W2042666243 @default.
- W4385273756 cites W2042705631 @default.
- W4385273756 cites W2048428229 @default.
- W4385273756 cites W2053631737 @default.
- W4385273756 cites W2054442403 @default.
- W4385273756 cites W2057886904 @default.
- W4385273756 cites W2059408709 @default.
- W4385273756 cites W2063130294 @default.
- W4385273756 cites W2064099550 @default.
- W4385273756 cites W2066908927 @default.
- W4385273756 cites W2068392219 @default.
- W4385273756 cites W2068991108 @default.
- W4385273756 cites W2069702624 @default.
- W4385273756 cites W2071638484 @default.
- W4385273756 cites W2073294726 @default.
- W4385273756 cites W2073678899 @default.
- W4385273756 cites W2081992825 @default.
- W4385273756 cites W2083197722 @default.
- W4385273756 cites W2088146297 @default.
- W4385273756 cites W2092185078 @default.
- W4385273756 cites W2093408741 @default.
- W4385273756 cites W2096809039 @default.
- W4385273756 cites W2098964008 @default.
- W4385273756 cites W2099174500 @default.
- W4385273756 cites W2099328612 @default.
- W4385273756 cites W2099544250 @default.
- W4385273756 cites W2100271507 @default.
- W4385273756 cites W2102375898 @default.
- W4385273756 cites W2104009484 @default.
- W4385273756 cites W2104053696 @default.
- W4385273756 cites W2106248075 @default.