Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385276759> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4385276759 abstract "Biological drugs are one of the most effective treatment methods for systemic juvenile idiopathic arthritis (SJIA) and can significantly prevent morbidity and mortality. This study aimed to evaluate the efficacy and safety of biologics in patients with SJIA and provide real-life data that might help improve the outcomes.TURSIS was a retrospective multicentre study carried out in patients with SJIA for whom a biological treatment had been initiated between 1st March 2013 and 30th December 2018. Data include patients' characteristics, laboratory-clinical results, outcomes, and safety-related variables. The 24-month follow-up data of the patients and the efficacy and safety of biological drugs were evaluated.147 patients were enrolled. The clinical course of the disease was as follows; it was monocyclic in 38.1%, polycyclic in 49%, and persistent in 12.9% of patients. First-choice biologics were interleukin (IL)-1 blockers in the majority of patients (56.5%), followed by the anti-IL-6 (25.2%) and anti-TNF-alpha drugs (18.4%). Anakinra was the most preferred biologic agent in patients with macrophage activation syndrome (MAS), and tocilizumab was used more frequently in patients with persistent type (p=0.000 and p=0.003). The most frequent switch rate was seen in patients receiving anakinra (n=40/68, 58.8%), and it was most frequently switched to canakinumab (n=32/40, 80%). Better physician's global assessment scores were achieved in patients treated with anakinra in Month 3, compared to other treatments (p=0.04).The results of our study support the efficacy of biological drugs in particular anti-IL-1 and anti-IL-6 drugs, in the treatment of SJIA. These treatments resulted in improvement in activity of disease and provide a considerable decrease in the frequency of MAS." @default.
- W4385276759 created "2023-07-27" @default.
- W4385276759 creator A5010382336 @default.
- W4385276759 creator A5014633647 @default.
- W4385276759 creator A5016347896 @default.
- W4385276759 creator A5019737021 @default.
- W4385276759 creator A5022048235 @default.
- W4385276759 creator A5024754731 @default.
- W4385276759 creator A5025449520 @default.
- W4385276759 creator A5027039554 @default.
- W4385276759 creator A5037791224 @default.
- W4385276759 creator A5041463384 @default.
- W4385276759 creator A5043870210 @default.
- W4385276759 creator A5045364229 @default.
- W4385276759 creator A5061188173 @default.
- W4385276759 creator A5074351117 @default.
- W4385276759 creator A5075045979 @default.
- W4385276759 creator A5077360794 @default.
- W4385276759 creator A5079636331 @default.
- W4385276759 creator A5085125040 @default.
- W4385276759 creator A5088374444 @default.
- W4385276759 date "2023-02-03" @default.
- W4385276759 modified "2023-10-17" @default.
- W4385276759 title "Evaluation of clinical outcomes in systemic juvenile idiopathic arthritis patients treated with biological agents in Turkey: the TURSIS study" @default.
- W4385276759 doi "https://doi.org/10.55563/clinexprheumatol/j611kr" @default.
- W4385276759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37497697" @default.
- W4385276759 hasPublicationYear "2023" @default.
- W4385276759 type Work @default.
- W4385276759 citedByCount "0" @default.
- W4385276759 crossrefType "journal-article" @default.
- W4385276759 hasAuthorship W4385276759A5010382336 @default.
- W4385276759 hasAuthorship W4385276759A5014633647 @default.
- W4385276759 hasAuthorship W4385276759A5016347896 @default.
- W4385276759 hasAuthorship W4385276759A5019737021 @default.
- W4385276759 hasAuthorship W4385276759A5022048235 @default.
- W4385276759 hasAuthorship W4385276759A5024754731 @default.
- W4385276759 hasAuthorship W4385276759A5025449520 @default.
- W4385276759 hasAuthorship W4385276759A5027039554 @default.
- W4385276759 hasAuthorship W4385276759A5037791224 @default.
- W4385276759 hasAuthorship W4385276759A5041463384 @default.
- W4385276759 hasAuthorship W4385276759A5043870210 @default.
- W4385276759 hasAuthorship W4385276759A5045364229 @default.
- W4385276759 hasAuthorship W4385276759A5061188173 @default.
- W4385276759 hasAuthorship W4385276759A5074351117 @default.
- W4385276759 hasAuthorship W4385276759A5075045979 @default.
- W4385276759 hasAuthorship W4385276759A5077360794 @default.
- W4385276759 hasAuthorship W4385276759A5079636331 @default.
- W4385276759 hasAuthorship W4385276759A5085125040 @default.
- W4385276759 hasAuthorship W4385276759A5088374444 @default.
- W4385276759 hasBestOaLocation W43852767591 @default.
- W4385276759 hasConcept C126322002 @default.
- W4385276759 hasConcept C167135981 @default.
- W4385276759 hasConcept C17991360 @default.
- W4385276759 hasConcept C2777077863 @default.
- W4385276759 hasConcept C2777178219 @default.
- W4385276759 hasConcept C2777226972 @default.
- W4385276759 hasConcept C2779134260 @default.
- W4385276759 hasConcept C2779613421 @default.
- W4385276759 hasConcept C2779725882 @default.
- W4385276759 hasConcept C2781228260 @default.
- W4385276759 hasConcept C2908564923 @default.
- W4385276759 hasConcept C2909063479 @default.
- W4385276759 hasConcept C71924100 @default.
- W4385276759 hasConceptScore W4385276759C126322002 @default.
- W4385276759 hasConceptScore W4385276759C167135981 @default.
- W4385276759 hasConceptScore W4385276759C17991360 @default.
- W4385276759 hasConceptScore W4385276759C2777077863 @default.
- W4385276759 hasConceptScore W4385276759C2777178219 @default.
- W4385276759 hasConceptScore W4385276759C2777226972 @default.
- W4385276759 hasConceptScore W4385276759C2779134260 @default.
- W4385276759 hasConceptScore W4385276759C2779613421 @default.
- W4385276759 hasConceptScore W4385276759C2779725882 @default.
- W4385276759 hasConceptScore W4385276759C2781228260 @default.
- W4385276759 hasConceptScore W4385276759C2908564923 @default.
- W4385276759 hasConceptScore W4385276759C2909063479 @default.
- W4385276759 hasConceptScore W4385276759C71924100 @default.
- W4385276759 hasLocation W43852767591 @default.
- W4385276759 hasLocation W43852767592 @default.
- W4385276759 hasOpenAccess W4385276759 @default.
- W4385276759 hasPrimaryLocation W43852767591 @default.
- W4385276759 hasRelatedWork W2066059652 @default.
- W4385276759 hasRelatedWork W2142659423 @default.
- W4385276759 hasRelatedWork W2767454393 @default.
- W4385276759 hasRelatedWork W2769476094 @default.
- W4385276759 hasRelatedWork W2947439298 @default.
- W4385276759 hasRelatedWork W2955105045 @default.
- W4385276759 hasRelatedWork W2996379371 @default.
- W4385276759 hasRelatedWork W3024688657 @default.
- W4385276759 hasRelatedWork W3165769683 @default.
- W4385276759 hasRelatedWork W4312825706 @default.
- W4385276759 isParatext "false" @default.
- W4385276759 isRetracted "false" @default.
- W4385276759 workType "article" @default.