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- W4385277484 abstract "Genetic factors in the HIV-background may play a significant role in the susceptibility to secondary diseases, like tuberculosis, which is the leading cause in mortality of HIV-positive people. Toll-like receptors (TLRs) are considered to be receptors for adaptive immunity, and polymorphisms in TLR genes can influence the activity of the immune response to infection. We conducted a case-control study of the association of TLR gene polymorphisms with the risk of tuberculosis coinfection in a multi-country sample of HIV-positive participants. Our study revealed certain associations between TLR4 and TLR6 polymorphisms and HIV-tuberculosis coinfection. We also found that the analyzed TLR1 and TLR4 polymorphisms were linked with the decline in CD4+ cell count, which is a predictor of disease progression in HIV-infected individuals. Our findings confirm that TLR gene polymorphisms are factors that may contribute to development of HIV-tuberculosis coinfection. However, the essence of the observed associations remains unclear, since it can also include both environmental factors and epigenetic mechanisms of gene expression regulation." @default.
- W4385277484 created "2023-07-27" @default.
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- W4385277484 date "2023-07-25" @default.
- W4385277484 modified "2023-09-27" @default.
- W4385277484 title "Association of Toll-Like Receptor Gene Polymorphisms with Tuberculosis in HIV-Positive Participants" @default.
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- W4385277484 doi "https://doi.org/10.3390/epigenomes7030015" @default.
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- W4385277484 hasPublicationYear "2023" @default.
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