Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385278024> ?p ?o ?g. }
- W4385278024 abstract "Abstract Background Stress has garnered significant attention as a prominent risk factor for inflammation-related diseases, particularly cardiovascular diseases (CVDs). However, the precise mechanisms underlying stress-driven CVDs remain elusive, thereby impeding the development of effective preventive and therapeutic strategies. Methods To explore the correlation between plasma lipid metabolites and depressive states, we conducted a study involving healthy volunteers (n=408). Liquid chromatography (LC)/mass spectrometry (MS)/MS-based lipidomics and the self-rating depression (SDS) scale questionnaire were employed for data collection. In addition, we utilized a mouse model by subjecting mice to restraint stress and investigating the impact of stress on plasma lipid metabolites and vascular remodeling following carotid ligation. In vitro functional and mechanistic studies were performed using macrophages, endothelial cells, and neutrophil cells. Results Our findings revealed a significant association between depressive state and reduced plasma levels of 4-oxoDHA, a specific omega-3 fatty acid metabolite regulated by 5-lipoxygenase (LO) in neutrophils in healthy volunteers. In mice, restraint stress led to decreased plasma 4-oxoDHA levels and exacerbated vascular remodeling. Moreover, 4-oxoDHA demonstrated the ability to enhance Nrf2-HO-1 pathways, exerting anti-inflammatory effects on endothelial cells and macrophages. Mechanistically, stress-induced noradrenaline triggered the degradation of 5-LO in neutrophils through the proteasome system, facilitated by dopamine D2-like receptor activation. The reduction in circulating 4-oxoDHA resulted in the downregulation of the Nrf2-HO-1 anti-inflammatory axis and an increase in ICAM-1 expression, vascular permeability, and remodeling. Conclusions Our study unveiled a novel stress-induced pathway of vascular inflammation, mediated through the regulation of omega-3 fatty acid metabolites. Reduced levels of circulating 4-oxoDHA under stress conditions may serve as a promising biomarker for stress. This understanding of the interplay between neurobiology and lipid metabolism provides a potential avenue for the development of treatments aimed at preventing stress-induced systemic neuroinflammation. Highlights – Our study reveals that stress-induced reduction in circulating levels of a specific omega-3 fatty acid metabolite, 4-oxoDHA, contributes to vascular inflammation. – We have identified a novel pathway that explains how stress promotes systemic vascular inflammation by regulating omega-3 fatty acid metabolites in the circulation. – Our findings provide new evidence for the role of 4-oxoDHA in maintaining Nrf2-ARE-related anti-inflammatory functions in endothelial cells and macrophages." @default.
- W4385278024 created "2023-07-27" @default.
- W4385278024 creator A5000182207 @default.
- W4385278024 creator A5002702817 @default.
- W4385278024 creator A5010683038 @default.
- W4385278024 creator A5012322656 @default.
- W4385278024 creator A5016204078 @default.
- W4385278024 creator A5032646427 @default.
- W4385278024 creator A5033044041 @default.
- W4385278024 creator A5048441665 @default.
- W4385278024 creator A5082560619 @default.
- W4385278024 creator A5087872679 @default.
- W4385278024 date "2023-07-25" @default.
- W4385278024 modified "2023-10-18" @default.
- W4385278024 title "Stress-induced vascular remodeling: novel insight into the role of omega-3 fatty acid metabolite, 4-oxoDHA" @default.
- W4385278024 cites W1070499447 @default.
- W4385278024 cites W1600536120 @default.
- W4385278024 cites W1958676502 @default.
- W4385278024 cites W1998234914 @default.
- W4385278024 cites W2004536682 @default.
- W4385278024 cites W2016008825 @default.
- W4385278024 cites W2020466729 @default.
- W4385278024 cites W2021907601 @default.
- W4385278024 cites W2028008424 @default.
- W4385278024 cites W2035809865 @default.
- W4385278024 cites W2039850229 @default.
- W4385278024 cites W2054016219 @default.
- W4385278024 cites W2066699861 @default.
- W4385278024 cites W2069943416 @default.
- W4385278024 cites W2072460110 @default.
- W4385278024 cites W2081378977 @default.
- W4385278024 cites W2086243699 @default.
- W4385278024 cites W2090609282 @default.
- W4385278024 cites W2107470338 @default.
- W4385278024 cites W2108373994 @default.
- W4385278024 cites W2112189542 @default.
- W4385278024 cites W2131271579 @default.
- W4385278024 cites W2132443029 @default.
- W4385278024 cites W2134539481 @default.
- W4385278024 cites W2142347023 @default.
- W4385278024 cites W2151356556 @default.
- W4385278024 cites W2155121555 @default.
- W4385278024 cites W2161952636 @default.
- W4385278024 cites W2168332652 @default.
- W4385278024 cites W2168699761 @default.
- W4385278024 cites W2170332928 @default.
- W4385278024 cites W2271472870 @default.
- W4385278024 cites W2523453502 @default.
- W4385278024 cites W2553117476 @default.
- W4385278024 cites W2585030762 @default.
- W4385278024 cites W2592811885 @default.
- W4385278024 cites W2773478070 @default.
- W4385278024 cites W2899669642 @default.
- W4385278024 cites W2903808414 @default.
- W4385278024 cites W2914453668 @default.
- W4385278024 cites W2929935816 @default.
- W4385278024 cites W2965334743 @default.
- W4385278024 cites W3014808794 @default.
- W4385278024 cites W3147536239 @default.
- W4385278024 doi "https://doi.org/10.1101/2023.07.25.550603" @default.
- W4385278024 hasPublicationYear "2023" @default.
- W4385278024 type Work @default.
- W4385278024 citedByCount "0" @default.
- W4385278024 crossrefType "posted-content" @default.
- W4385278024 hasAuthorship W4385278024A5000182207 @default.
- W4385278024 hasAuthorship W4385278024A5002702817 @default.
- W4385278024 hasAuthorship W4385278024A5010683038 @default.
- W4385278024 hasAuthorship W4385278024A5012322656 @default.
- W4385278024 hasAuthorship W4385278024A5016204078 @default.
- W4385278024 hasAuthorship W4385278024A5032646427 @default.
- W4385278024 hasAuthorship W4385278024A5033044041 @default.
- W4385278024 hasAuthorship W4385278024A5048441665 @default.
- W4385278024 hasAuthorship W4385278024A5082560619 @default.
- W4385278024 hasAuthorship W4385278024A5087872679 @default.
- W4385278024 hasBestOaLocation W43852780241 @default.
- W4385278024 hasConcept C104317684 @default.
- W4385278024 hasConcept C126322002 @default.
- W4385278024 hasConcept C127561419 @default.
- W4385278024 hasConcept C185592680 @default.
- W4385278024 hasConcept C2776151105 @default.
- W4385278024 hasConcept C2776246508 @default.
- W4385278024 hasConcept C2776914184 @default.
- W4385278024 hasConcept C2777477808 @default.
- W4385278024 hasConcept C2780972559 @default.
- W4385278024 hasConcept C55493867 @default.
- W4385278024 hasConcept C58017582 @default.
- W4385278024 hasConcept C71924100 @default.
- W4385278024 hasConcept C98274493 @default.
- W4385278024 hasConceptScore W4385278024C104317684 @default.
- W4385278024 hasConceptScore W4385278024C126322002 @default.
- W4385278024 hasConceptScore W4385278024C127561419 @default.
- W4385278024 hasConceptScore W4385278024C185592680 @default.
- W4385278024 hasConceptScore W4385278024C2776151105 @default.
- W4385278024 hasConceptScore W4385278024C2776246508 @default.
- W4385278024 hasConceptScore W4385278024C2776914184 @default.
- W4385278024 hasConceptScore W4385278024C2777477808 @default.
- W4385278024 hasConceptScore W4385278024C2780972559 @default.
- W4385278024 hasConceptScore W4385278024C55493867 @default.
- W4385278024 hasConceptScore W4385278024C58017582 @default.
- W4385278024 hasConceptScore W4385278024C71924100 @default.