FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385278380> ?p ?o ?g. }

• W4385278380 abstract "Suppression of the antitumor cytokine interleukin-24 (IL-24) is critical for the survival of myxoid liposarcoma (MLS) cells. It has been previously demonstrated by the authors that an MLS-specific chimeric oncoprotein, translocated in liposarcoma-CCAAT/enhancer-binding protein homologous protein (TLS-CHOP), supresses IL24 mRNA expression via induction of proteoglycan 4 (PRG4) to sustain MLS cell proliferation. However, IL-24 has also been revealed to be suppressed by the ubiquitin-proteasome system in human ovarian and lung cancer cells. Therefore, the aim of the present study was to elucidate the mechanism of IL-24 suppression in MLS cells. The results revealed that the proteasome inhibitor, MG-132, induced cell death in MLS cells in vitro; this effect was reduced following IL-24 knockdown. This indicated that proteasomal degradation of IL-24 may be an important process for MLS cell survival. In addition, it was also previously revealed by the authors that knockdown of plasminogen activator inhibitor-1 (PAI-1), a TLS-CHOP downstream molecule, suppressed the growth of MLS cells, thus instigating the investigation of the effect of PAI-1 on IL-24 expression in MLS cells. Double knockdown of PAI-1 and IL-24 negated the growth-suppressive effect of PAI-1 single knockdown in MLS cells. Interestingly, PAI-1 single knockdown did not increase the mRNA expression of IL24, but it did increase the protein abundance of IL-24, indicating that PAI-1 suppressed IL-24 expression by promoting its proteasomal degradation. Moreover, treatment of MLS cells with a PAI-1 inhibitor, TM5275, induced IL-24 protein expression and apoptosis. Collectively, the results of the present as well as previous studies indicated that IL-24 expression may be suppressed at the transcriptional level by PRG4 and at the protein level by PAI-1 in MLS cells. Accordingly, PAI-1 may represent an effective therapeutic target for MLS treatment." @default.
• W4385278380 created "2023-07-27" @default.
• W4385278380 creator A5005230545 @default.
• W4385278380 creator A5012362577 @default.
• W4385278380 creator A5056598242 @default.
• W4385278380 date "2023-07-26" @default.
• W4385278380 modified "2023-10-16" @default.
• W4385278380 title "Suppression of antitumor cytokine IL‑24 by PRG4 and PAI‑1 may promote myxoid liposarcoma cell survival" @default.
• W4385278380 cites W1036791879 @default.
• W4385278380 cites W1535584123 @default.
• W4385278380 cites W1969869631 @default.
• W4385278380 cites W1989510923 @default.
• W4385278380 cites W1992063032 @default.
• W4385278380 cites W2001980530 @default.
• W4385278380 cites W2006569353 @default.
• W4385278380 cites W2011515761 @default.
• W4385278380 cites W2017853784 @default.
• W4385278380 cites W2019072035 @default.
• W4385278380 cites W2020261860 @default.
• W4385278380 cites W2023386504 @default.
• W4385278380 cites W2027546021 @default.
• W4385278380 cites W2031900842 @default.
• W4385278380 cites W2042404839 @default.
• W4385278380 cites W2046399928 @default.
• W4385278380 cites W2048077855 @default.
• W4385278380 cites W2055085369 @default.
• W4385278380 cites W2059707627 @default.
• W4385278380 cites W2068051800 @default.
• W4385278380 cites W2069323103 @default.
• W4385278380 cites W2075185862 @default.
• W4385278380 cites W2076058175 @default.
• W4385278380 cites W2078803864 @default.
• W4385278380 cites W2081276164 @default.
• W4385278380 cites W2093528151 @default.
• W4385278380 cites W2097786065 @default.
• W4385278380 cites W2099045184 @default.
• W4385278380 cites W2153392167 @default.
• W4385278380 cites W2234798757 @default.
• W4385278380 cites W2293303878 @default.
• W4385278380 cites W2587346598 @default.
• W4385278380 cites W2754762730 @default.
• W4385278380 cites W2789281303 @default.
• W4385278380 cites W2805709488 @default.
• W4385278380 cites W2966487576 @default.
• W4385278380 cites W2978398809 @default.
• W4385278380 cites W2984946521 @default.
• W4385278380 cites W2985249484 @default.
• W4385278380 cites W3085241862 @default.
• W4385278380 cites W3127229988 @default.
• W4385278380 cites W3163174031 @default.
• W4385278380 cites W4200505410 @default.
• W4385278380 cites W4242089499 @default.
• W4385278380 doi "https://doi.org/10.3892/br.2023.1642" @default.
• W4385278380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37614985" @default.
• W4385278380 hasPublicationYear "2023" @default.
• W4385278380 type Work @default.
• W4385278380 citedByCount "0" @default.
• W4385278380 crossrefType "journal-article" @default.
• W4385278380 hasAuthorship W4385278380A5005230545 @default.
• W4385278380 hasAuthorship W4385278380A5012362577 @default.
• W4385278380 hasAuthorship W4385278380A5056598242 @default.
• W4385278380 hasBestOaLocation W43852783801 @default.
• W4385278380 hasConcept C153911025 @default.
• W4385278380 hasConcept C158617107 @default.
• W4385278380 hasConcept C173396325 @default.
• W4385278380 hasConcept C190283241 @default.
• W4385278380 hasConcept C27740335 @default.
• W4385278380 hasConcept C2778367456 @default.
• W4385278380 hasConcept C2779725641 @default.
• W4385278380 hasConcept C502942594 @default.
• W4385278380 hasConcept C55493867 @default.
• W4385278380 hasConcept C86803240 @default.
• W4385278380 hasConcept C95444343 @default.
• W4385278380 hasConceptScore W4385278380C153911025 @default.
• W4385278380 hasConceptScore W4385278380C158617107 @default.
• W4385278380 hasConceptScore W4385278380C173396325 @default.
• W4385278380 hasConceptScore W4385278380C190283241 @default.
• W4385278380 hasConceptScore W4385278380C27740335 @default.
• W4385278380 hasConceptScore W4385278380C2778367456 @default.
• W4385278380 hasConceptScore W4385278380C2779725641 @default.
• W4385278380 hasConceptScore W4385278380C502942594 @default.
• W4385278380 hasConceptScore W4385278380C55493867 @default.
• W4385278380 hasConceptScore W4385278380C86803240 @default.
• W4385278380 hasConceptScore W4385278380C95444343 @default.
• W4385278380 hasIssue "3" @default.
• W4385278380 hasLocation W43852783801 @default.
• W4385278380 hasLocation W43852783802 @default.
• W4385278380 hasOpenAccess W4385278380 @default.
• W4385278380 hasPrimaryLocation W43852783801 @default.
• W4385278380 hasRelatedWork W1970235416 @default.
• W4385278380 hasRelatedWork W2068994409 @default.
• W4385278380 hasRelatedWork W2243925837 @default.
• W4385278380 hasRelatedWork W2349423403 @default.
• W4385278380 hasRelatedWork W2366739641 @default.
• W4385278380 hasRelatedWork W2377566722 @default.
• W4385278380 hasRelatedWork W2397241232 @default.
• W4385278380 hasRelatedWork W4361248851 @default.
• W4385278380 hasRelatedWork W4361248869 @default.
• W4385278380 hasRelatedWork W611485748 @default.
• W4385278380 hasVolume "19" @default.

• next