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- W4385280584 abstract "Thiourea derivatives are well known class of organic compounds having diverse application in the field of medicine, agriculture, coordination, and analytical chemistry. This study reports novel N1-(2-chlorophenyl)-N2-phenyl-1,2-hydrazinedicarbothioamide and its Mn (II),Co(II), Ni(II),Cu(II), metal complexes. These synthesized compounds were characterized by H1NMR, UV-Vis, IR spectroscopy and elemental (CHN/S) analysis. Moreover, antioxidant activity was screened for synthesized compounds. All the compounds showed significant antioxidant potential with IC50 values ranges from 23.81± 1.57µM - 58.32± 1.23µM. It was revealed that synthesized compounds displayed better antioxidant activity with IC50 values between 127.10-271.41 µM to256.42 ± 0.34 µM. The ligand (IC50 =33.41 ± 1.32µM)as well as metal complex Cu(L)2 (IC50 = 28.10± 1.05µM ), Zn(L)2 (IC50 = 24.53± 1.12µM), ZrO(L)2 (IC50 = 58.32± 1.23µM), Hg(L)2 (IC50 = 23.81± 1.57µM ), UO2(L)2 (IC50 =52.14± 1.45µM) showed far better activity than the standard (IC50 = 44.7± 1.21). Among these metal complexes, Hg complex (IC50 = 23.81 ± 1.57) showed highest antioxidant activity, while Zn complex (IC50= 24.53 ± 1.12), Cu complex (28.10 ± 1.05) and Co complex (IC50= 29.76 ± 1.21), The metal complexes UO2(L)2, ZrO(L)2 showed moderate anti-oxidant activity. These compounds were found be less active than other metal complexes as well as standard. The antioxidant activity pattern of these compounds is Hg(L)2 > Zn(L)2 > Cu(L)2 > UO2(L) > ZrO(L)2. These metal complexes showed remarkable antioxidant activity which may find their importance in avoiding or reducing the development of both heart disease and some forms of cancer." @default.
- W4385280584 created "2023-07-27" @default.
- W4385280584 date "2022-09-23" @default.
- W4385280584 modified "2023-09-23" @default.
- W4385280584 title "Characterization and antioxidant activity of newly synthesized N1-(2-chlorophenyl)-N2-phenyl-1,2-hydrazinedicarbothioamide and its Cu(II), Zn(II), ZrO(II), Hg(II) and UO2(II) metal complexes" @default.
- W4385280584 doi "https://doi.org/10.26692/surj-ss.v54i3.4868" @default.
- W4385280584 hasPublicationYear "2022" @default.
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