Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385285215> ?p ?o ?g. }
- W4385285215 abstract "Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of cell death and a substrate of Caspase-8. However, the physiological role of cFLIP cleavage by Caspase-8 remains elusive. Here, we found an essential role for cFLIP cleavage in restraining cell death in different pathophysiological scenarios. Mice expressing a cleavage-resistant cFLIP mutant, Cflip D377A , exhibited increased sensitivity to severe acute respiratory syndrome coronavirus (SARS-CoV)–induced lethality, impaired skin wound healing, and increased tissue damage caused by Sharpin deficiency. In vitro, abrogation of cFLIP cleavage sensitizes cells to tumor necrosis factor(TNF)–induced necroptosis and apoptosis by favoring complex-II formation. Mechanistically, the cell death–sensitizing effect of the D377A mutation depends on glutamine-469. These results reveal a crucial role for cFLIP cleavage in controlling the amplitude of cell death responses occurring upon tissue stress to ensure the execution of repair programs." @default.
- W4385285215 created "2023-07-27" @default.
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- W4385285215 date "2023-07-28" @default.
- W4385285215 modified "2023-10-02" @default.
- W4385285215 title "Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair" @default.
- W4385285215 cites W1491235873 @default.
- W4385285215 cites W1509082948 @default.
- W4385285215 cites W1803162504 @default.
- W4385285215 cites W1857408336 @default.
- W4385285215 cites W1963580683 @default.
- W4385285215 cites W1975593978 @default.
- W4385285215 cites W1979444649 @default.
- W4385285215 cites W1981860684 @default.
- W4385285215 cites W1985529376 @default.
- W4385285215 cites W1989501155 @default.
- W4385285215 cites W1997080155 @default.
- W4385285215 cites W1998423564 @default.
- W4385285215 cites W2002154440 @default.
- W4385285215 cites W2003534444 @default.
- W4385285215 cites W2006717892 @default.
- W4385285215 cites W2017985723 @default.
- W4385285215 cites W2027021865 @default.
- W4385285215 cites W2027104029 @default.
- W4385285215 cites W2028626533 @default.
- W4385285215 cites W2059444339 @default.
- W4385285215 cites W2061294496 @default.
- W4385285215 cites W2070172947 @default.
- W4385285215 cites W2081888548 @default.
- W4385285215 cites W2088573055 @default.
- W4385285215 cites W2090903823 @default.
- W4385285215 cites W2114727688 @default.
- W4385285215 cites W2124202816 @default.
- W4385285215 cites W2125548716 @default.
- W4385285215 cites W2127080680 @default.
- W4385285215 cites W2129627069 @default.
- W4385285215 cites W2133794670 @default.
- W4385285215 cites W2135332272 @default.
- W4385285215 cites W2166793740 @default.
- W4385285215 cites W2170554156 @default.
- W4385285215 cites W2190558971 @default.
- W4385285215 cites W2267633848 @default.
- W4385285215 cites W2300529787 @default.
- W4385285215 cites W2474614962 @default.
- W4385285215 cites W2474828131 @default.
- W4385285215 cites W2535050761 @default.
- W4385285215 cites W2613123103 @default.
- W4385285215 cites W2755200731 @default.
- W4385285215 cites W2773003990 @default.
- W4385285215 cites W2788004032 @default.
- W4385285215 cites W2900410132 @default.
- W4385285215 cites W2901287717 @default.
- W4385285215 cites W2935784454 @default.
- W4385285215 cites W2942035615 @default.
- W4385285215 cites W2972960041 @default.
- W4385285215 cites W2995000440 @default.
- W4385285215 cites W2995123617 @default.
- W4385285215 cites W3003914027 @default.
- W4385285215 cites W3011113661 @default.
- W4385285215 cites W3011994965 @default.
- W4385285215 cites W3013796529 @default.
- W4385285215 cites W3023862641 @default.
- W4385285215 cites W3039372851 @default.
- W4385285215 cites W3089289965 @default.
- W4385285215 cites W3092576617 @default.
- W4385285215 cites W3105908160 @default.
- W4385285215 cites W3163391101 @default.
- W4385285215 cites W3169025220 @default.
- W4385285215 cites W3209103161 @default.
- W4385285215 cites W4210931868 @default.
- W4385285215 cites W4280576708 @default.