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• W4385285588 abstract "Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a faster rate than heart disease and cancer. While the disease presents clinically as chronic hyperglycaemia, two distinct subtypes have been recognised. Type 1 diabetes (T1D) is characterised as an autoimmune disease in which the insulin-producing pancreatic β-cells are destroyed, and type 2 diabetes (T2D) arises due to metabolic insufficiency, in which inadequate amounts of insulin are produced, and/or the actions of insulin are diminished. It is now apparent that pro-inflammatory responses cause a loss of functional β-cell mass, and this is the common underlying mechanism of both T1D and T2D. Macrophages are the central immune cells in the pathogenesis of both diseases and play a major role in the initiation and perpetuation of the proinflammatory responses that compromise β-cell function. Furthermore, it is the crosstalk between macrophages and β-cells that orchestrates the inflammatory response and ensuing β-cell dysfunction/destruction. Conversely, this crosstalk can induce immune tolerance and preservation of β-cell mass and function. Thus, specifically targeting the intercellular communication between macrophages and β-cells offers a unique strategy to prevent/halt the islet inflammatory events underpinning T1D and T2D. Due to their potent ability to regulate mammalian immune responses, parasitic worms (helminths), and their excretory/secretory products, have been examined for their potential as therapeutic agents for both T1D and T2D. This research has yielded positive results in disease prevention, both clinically and in animal models. However, the focus of research has been on the modulation of immune cells and their effectors. This approach has ignored the direct effects of helminths and their products on β-cells, and the modulation of signal exchange between macrophages and β-cells. This review explores how the alterations to macrophages induced by helminths, and their products, influence the crosstalk with β-cells to promote their function and survival. In addition, the evidence that parasite-derived products interact directly with endocrine cells to influence their communication with macrophages to prevent β-cell death and enhance function is discussed. This new paradigm of two-way metabolic conversations between endocrine cells and macrophages opens new avenues for the treatment of immune-mediated metabolic disease." @default.
• W4385285588 created "2023-07-27" @default.
• W4385285588 creator A5048119828 @default.
• W4385285588 creator A5051381158 @default.
• W4385285588 creator A5072057358 @default.
• W4385285588 date "2023-07-26" @default.
• W4385285588 modified "2023-09-23" @default.
• W4385285588 title "How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk" @default.
• W4385285588 cites W1481057445 @default.
• W4385285588 cites W1530509485 @default.
• W4385285588 cites W1532807611 @default.
• W4385285588 cites W1596700184 @default.
• W4385285588 cites W1631191231 @default.
• W4385285588 cites W1863320924 @default.
• W4385285588 cites W1918968064 @default.
• W4385285588 cites W1954497589 @default.
• W4385285588 cites W1966977991 @default.
• W4385285588 cites W1968961392 @default.
• W4385285588 cites W1974526014 @default.
• W4385285588 cites W1981231681 @default.
• W4385285588 cites W1982715049 @default.
• W4385285588 cites W1983357763 @default.
• W4385285588 cites W1985408969 @default.
• W4385285588 cites W1990902267 @default.
• W4385285588 cites W1992445331 @default.
• W4385285588 cites W2003965937 @default.
• W4385285588 cites W2009739922 @default.
• W4385285588 cites W2011395619 @default.
• W4385285588 cites W2018866981 @default.
• W4385285588 cites W2018996778 @default.
• W4385285588 cites W2023478520 @default.
• W4385285588 cites W2023914369 @default.
• W4385285588 cites W2027552805 @default.
• W4385285588 cites W2033209163 @default.
• W4385285588 cites W2036295062 @default.
• W4385285588 cites W2040153748 @default.
• W4385285588 cites W2048211245 @default.
• W4385285588 cites W2050870518 @default.
• W4385285588 cites W2051692047 @default.
• W4385285588 cites W2052472267 @default.
• W4385285588 cites W2057898581 @default.
• W4385285588 cites W2077328790 @default.
• W4385285588 cites W2082683537 @default.
• W4385285588 cites W2083505983 @default.
• W4385285588 cites W2084750010 @default.
• W4385285588 cites W2090613865 @default.
• W4385285588 cites W2093257146 @default.
• W4385285588 cites W2102473693 @default.
• W4385285588 cites W2104901632 @default.
• W4385285588 cites W2112154049 @default.
• W4385285588 cites W2113145530 @default.
• W4385285588 cites W2115338157 @default.
• W4385285588 cites W2115677315 @default.
• W4385285588 cites W2122798447 @default.
• W4385285588 cites W2124700037 @default.
• W4385285588 cites W2126643398 @default.
• W4385285588 cites W2127371447 @default.
• W4385285588 cites W2127379971 @default.
• W4385285588 cites W2127788605 @default.
• W4385285588 cites W2133064834 @default.
• W4385285588 cites W2134749535 @default.
• W4385285588 cites W2138134702 @default.
• W4385285588 cites W2139923324 @default.
• W4385285588 cites W2145690342 @default.
• W4385285588 cites W2146259054 @default.
• W4385285588 cites W2146561547 @default.
• W4385285588 cites W2147810846 @default.
• W4385285588 cites W2156044622 @default.
• W4385285588 cites W2156178288 @default.
• W4385285588 cites W2157476554 @default.
• W4385285588 cites W2159571285 @default.
• W4385285588 cites W2162965492 @default.
• W4385285588 cites W2171618949 @default.
• W4385285588 cites W2263039862 @default.
• W4385285588 cites W2266478788 @default.
• W4385285588 cites W2332910275 @default.
• W4385285588 cites W2344940232 @default.
• W4385285588 cites W2517098568 @default.
• W4385285588 cites W2525640759 @default.
• W4385285588 cites W2554106971 @default.
• W4385285588 cites W2555384684 @default.
• W4385285588 cites W2555537533 @default.
• W4385285588 cites W2603423870 @default.
• W4385285588 cites W2606914311 @default.
• W4385285588 cites W2607665808 @default.
• W4385285588 cites W2730470503 @default.
• W4385285588 cites W2730923948 @default.
• W4385285588 cites W2750670686 @default.
• W4385285588 cites W2756212906 @default.
• W4385285588 cites W2767838035 @default.
• W4385285588 cites W2770280039 @default.
• W4385285588 cites W2791242266 @default.
• W4385285588 cites W2793584189 @default.
• W4385285588 cites W2794761283 @default.
• W4385285588 cites W2795402810 @default.
• W4385285588 cites W2797051913 @default.
• W4385285588 cites W2801913957 @default.
• W4385285588 cites W2807449338 @default.
• W4385285588 cites W2883287543 @default.
• W4385285588 cites W2890365959 @default.

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