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- W4385294510 abstract "To describe long-term quality of life (QOL) and gastrointestinal (GI) symptoms in patients who underwent pancreatoduodenectomy for pancreatic cancer in the modern era.As advances in pancreatic cancer management improve outcomes, it is essential to assess long-term patient reported outcomes after surgery.Patients who underwent curative intent pancreatoduodenectomy for pancreatic cancer between 1/2011-6/2019 from a single-center were identified. Patients alive ≥3 years after surgery were considered long-term survivors (LTS). LTS who were alive in 6/2022 received a 55-question survey to assess their QOL (EORTC-QLQ-C30) and GI symptoms (EORTC-PAN26 and Problem Areas in Diabetes Questionnaire). Responses were compared against population norms. Clinicodemographic characteristics in LTS vs non-LTS and survey completion were compared.Six-hundred and seventy-two patients underwent pancreatoduodenectomy for pancreatic cancer; 340 were long-term survivors. One-hundred and thirty-seven patients of the 238 eligible to complete the survey responded (response rate: 58%). Compared to the US general population, long-term survivors reported significantly higher QOL (75 vs 64; P <0.001), less nausea/vomiting, pain, dyspnea, insomnia, appetite loss, and constipation, but more diarrhea (all P <0.001). Most patients (n=136/137, 99%) reported experiencing postoperative GI symptoms related to pancreatic insufficiency (n=71/135, 53%), reflux (n=61/135, 45%), delayed gastric emptying (n=31/136, 23%). Most patients (n=113/136, 83%) reported that digestive symptoms overall had little to no impact on QOL, and 91% (n=124/136) would undergo surgery again.Despite known long-term complications following pancreatoduodenectomy, cancer survivors appear to have excellent QOL. Specific long-term gastrointestinal symptoms data should be utilized for preoperative education and follow-up planning." @default.
- W4385294510 created "2023-07-28" @default.
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- W4385294510 date "2023-07-27" @default.
- W4385294510 modified "2023-09-23" @default.
- W4385294510 title "Quality of Life and Gastrointestinal Symptoms in Long-term Survivors of Pancreatic Cancer Following Pancreatoduodenectomy" @default.
- W4385294510 doi "https://doi.org/10.1097/sla.0000000000006053" @default.
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