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- W4385295310 abstract "Purpose: To analyze whether adding PI3K/AKT/mTOR inhibitors to fulvestrant could restore endocrine therapy sensitivity for the treatment of postmenopausal patients with HR+, HER2- breast cancer. Methods: This meta-analysis was performed using RevMan 5.4 analysis software. Results: Nine studies that included a total of 3199 patients were analyzed. Compared with fulvestrant alone, the addition of PI3K/AKT/mTOR inhibitors significantly prolonged progression-free survival, overall survival and objective response rate of patients in both the total and PI3K-pathway-activated population. The number of grade 3-5 adverse events was also significantly higher. Conclusion: The addition of PI3K/AKT/mTOR to fulvestrant resulted in potential benefits; however, there may be a higher risk, which needs to be carefully managed." @default.
- W4385295310 created "2023-07-28" @default.
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- W4385295310 date "2023-06-01" @default.
- W4385295310 modified "2023-09-23" @default.
- W4385295310 title "Addition of <i>PI3K/AKT/mTOR</i> inhibitors to fulvestrant for advanced <i>HR+/HER2-</i> breast cancer: a systematic review and meta-analysis" @default.
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- W4385295310 doi "https://doi.org/10.2217/fon-2022-1220" @default.
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