FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385295384> ?p ?o ?g. }

• W4385295384 abstract "The vertebrate brain is highly conserved topologically, but less is known about neuroanatomical variation between individual brain regions. Neuroanatomical variation at the regional level is hypothesized to provide functional expansion, building upon ancestral anatomy needed for basic functions. Classically, animal models used to study evolution have lacked tools for detailed anatomical analysis that are widely used in zebrafish and mice, presenting a barrier to studying brain evolution at fine scales. In this study, we sought to investigate the evolution of brain anatomy using a single species of fish consisting of divergent surface and cave morphs, that permits functional genetic testing of regional volume and shape across the entire brain. We generated a high-resolution brain atlas for the blind Mexican cavefish Astyanax mexicanus and coupled the atlas with automated computational tools to directly assess variability in brain region shape and volume across all populations. We measured the volume and shape of every grossly defined neuroanatomical region of the brain and assessed correlations between anatomical regions in surface fish, cavefish, and surface × cave F 2 hybrids, whose phenotypes span the range of surface to cave. We find that dorsal regions of the brain are contracted, while ventral regions have expanded, with F 2 hybrid data providing support for developmental constraint along the dorsal-ventral axis. Furthermore, these dorsal-ventral relationships in anatomical variation show similar patterns for both volume and shape, suggesting that the anatomical evolution captured by these two parameters could be driven by similar developmental mechanisms. Together, these data demonstrate that A. mexicanus is a powerful system for functionally determining basic principles of brain evolution and will permit testing how genes influence early patterning events to drive brain-wide anatomical evolution." @default.
• W4385295384 created "2023-07-28" @default.
• W4385295384 creator A5002062705 @default.
• W4385295384 creator A5015415133 @default.
• W4385295384 creator A5029765045 @default.
• W4385295384 creator A5041580356 @default.
• W4385295384 creator A5041865755 @default.
• W4385295384 creator A5043636214 @default.
• W4385295384 creator A5056069759 @default.
• W4385295384 creator A5064744862 @default.
• W4385295384 creator A5069602798 @default.
• W4385295384 creator A5086327955 @default.
• W4385295384 creator A5090391818 @default.
• W4385295384 creator A5091270721 @default.
• W4385295384 date "2023-07-27" @default.
• W4385295384 modified "2023-09-29" @default.
• W4385295384 title "A brain-wide analysis maps structural evolution to distinct anatomical module" @default.
• W4385295384 cites W1490017765 @default.
• W4385295384 cites W1496014351 @default.
• W4385295384 cites W1669925514 @default.
• W4385295384 cites W1767712531 @default.
• W4385295384 cites W1796514810 @default.
• W4385295384 cites W1832672176 @default.
• W4385295384 cites W1926834468 @default.
• W4385295384 cites W1970312849 @default.
• W4385295384 cites W1981705330 @default.
• W4385295384 cites W1989062378 @default.
• W4385295384 cites W1995418302 @default.
• W4385295384 cites W1996306915 @default.
• W4385295384 cites W1998648802 @default.
• W4385295384 cites W1999109874 @default.
• W4385295384 cites W2002653689 @default.
• W4385295384 cites W2007829231 @default.
• W4385295384 cites W2020775714 @default.
• W4385295384 cites W2025053472 @default.
• W4385295384 cites W2042335929 @default.
• W4385295384 cites W2043699984 @default.
• W4385295384 cites W2047578534 @default.
• W4385295384 cites W2052845516 @default.
• W4385295384 cites W2053117825 @default.
• W4385295384 cites W2054106419 @default.
• W4385295384 cites W2055149957 @default.
• W4385295384 cites W2055726879 @default.
• W4385295384 cites W2059614045 @default.
• W4385295384 cites W2071179747 @default.
• W4385295384 cites W2074067714 @default.
• W4385295384 cites W2074454145 @default.
• W4385295384 cites W2075309963 @default.
• W4385295384 cites W2076541146 @default.
• W4385295384 cites W2078551845 @default.
• W4385295384 cites W2081466141 @default.
• W4385295384 cites W2105249648 @default.
• W4385295384 cites W2118342112 @default.
• W4385295384 cites W2121893022 @default.
• W4385295384 cites W2128441764 @default.
• W4385295384 cites W2131278302 @default.
• W4385295384 cites W2134436946 @default.
• W4385295384 cites W2136145485 @default.
• W4385295384 cites W2138643777 @default.
• W4385295384 cites W2140161481 @default.
• W4385295384 cites W2146714846 @default.
• W4385295384 cites W2148944713 @default.
• W4385295384 cites W2149361198 @default.
• W4385295384 cites W2151659916 @default.
• W4385295384 cites W2152745200 @default.
• W4385295384 cites W2153664306 @default.
• W4385295384 cites W2154321716 @default.
• W4385295384 cites W2157064730 @default.
• W4385295384 cites W2161254621 @default.
• W4385295384 cites W2165314777 @default.
• W4385295384 cites W2166241138 @default.
• W4385295384 cites W2170333515 @default.
• W4385295384 cites W2277956273 @default.
• W4385295384 cites W2292095104 @default.
• W4385295384 cites W2520236142 @default.
• W4385295384 cites W2527833694 @default.
• W4385295384 cites W2581259096 @default.
• W4385295384 cites W2598433719 @default.
• W4385295384 cites W2604243177 @default.
• W4385295384 cites W2752565229 @default.
• W4385295384 cites W2757044841 @default.
• W4385295384 cites W2785754928 @default.
• W4385295384 cites W2785913932 @default.
• W4385295384 cites W2799411545 @default.
• W4385295384 cites W2803841419 @default.
• W4385295384 cites W2806176244 @default.
• W4385295384 cites W2806589727 @default.
• W4385295384 cites W2808816401 @default.
• W4385295384 cites W2895353742 @default.
• W4385295384 cites W2897525775 @default.
• W4385295384 cites W2898274719 @default.
• W4385295384 cites W2899860682 @default.
• W4385295384 cites W2900568561 @default.
• W4385295384 cites W2950194569 @default.
• W4385295384 cites W2952378441 @default.
• W4385295384 cites W2952478785 @default.
• W4385295384 cites W2962856954 @default.
• W4385295384 cites W2979235709 @default.
• W4385295384 cites W3006043688 @default.
• W4385295384 cites W3014873564 @default.

• next