Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385296462> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4385296462 endingPage "827" @default.
- W4385296462 startingPage "815" @default.
- W4385296462 abstract "Diaminodichoroplatinum (DDP) resistance of tumor cells is the culprit of nasopharyngeal carcinoma (NPC) treatment failure. MicroRNA-577 is lowly expressed in NPC tissues, but relevant mechanism is poorly studied. Therefore, this study investigated the role of microRNA-577 in NPC cells with DDP resistance and its mechanism. DDP-resistant NPC cells were established by treatment with DDP at increased concentrations (2, 4, 6, 8, or 10 μg/mL). MicroRNA-577 and EIF5A2 mRNA expressions were detected by qRT-PCR. Cell biological behaviors were assessed via cell function experiments. Expressions of epithelial mesenchymal transformation (EMT)-related proteins were quantified by western blot. The targeting relationship between eukaryotic translation initiation factor 5A2 (EIF5A2) and microRNA-577 was verified through dual-luciferase reporter assay. The tumor volume and weight were measured after subcutaneous tumorigenesis in mice. As observed from the results, microRNA-577 expression was reduced in NPC cells and DDP-resistant NPC cells. Up-regulated microRNA-577 suppressed the malignant behaviors and EMT of DDP-resistant NPC cells, and facilitated cell apoptosis. MicroRNA-577 targeted EIF5A2, and overexpressed EIF5A2 reversed the above effects of up-regulated microRNA-577 on DDP-resistant NPC cells. Besides, EIF5A2 positively regulated TGF-β signaling pathway, and TGF-β treatment offset the promoting effects of EIF5A2 silencing on apoptosis of DDP-resistant NPC cells. Up-regulated microRNA-577 suppressed the proliferation of DDP-resistant NPC cells, and down-regulated the levels of EIF5A2 and TGF-β as well as EMT in vivo. Collectively, microRNA-577/EIF5A2 axis hinders the EMT progression through the blockage of TGF-β signaling pathway, so as to inhibit the proliferation of DDP-resistant NPC." @default.
- W4385296462 created "2023-07-28" @default.
- W4385296462 creator A5017565565 @default.
- W4385296462 creator A5025241271 @default.
- W4385296462 creator A5052501867 @default.
- W4385296462 creator A5068298797 @default.
- W4385296462 date "2023-07-27" @default.
- W4385296462 modified "2023-10-14" @default.
- W4385296462 title "<scp>MicroRNA</scp>‐577/<scp>EIF5A2</scp> axis suppressed the proliferation of <scp>DDP</scp>‐resistant nasopharyngeal carcinoma cells by blocking <scp>TGF</scp>‐β signaling pathway" @default.
- W4385296462 cites W1967005799 @default.
- W4385296462 cites W2039403882 @default.
- W4385296462 cites W2055164218 @default.
- W4385296462 cites W2102723674 @default.
- W4385296462 cites W2107277218 @default.
- W4385296462 cites W2585032307 @default.
- W4385296462 cites W272899539 @default.
- W4385296462 cites W2807165179 @default.
- W4385296462 cites W2884127057 @default.
- W4385296462 cites W2900933518 @default.
- W4385296462 cites W2917837889 @default.
- W4385296462 cites W2929491112 @default.
- W4385296462 cites W2950079277 @default.
- W4385296462 cites W2963395821 @default.
- W4385296462 cites W2979189134 @default.
- W4385296462 cites W2991216234 @default.
- W4385296462 cites W2997134127 @default.
- W4385296462 cites W3024414049 @default.
- W4385296462 cites W3077281576 @default.
- W4385296462 cites W3127571686 @default.
- W4385296462 cites W3182331653 @default.
- W4385296462 cites W3197674997 @default.
- W4385296462 cites W4247544731 @default.
- W4385296462 doi "https://doi.org/10.1111/cbdd.14293" @default.
- W4385296462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37500510" @default.
- W4385296462 hasPublicationYear "2023" @default.
- W4385296462 type Work @default.
- W4385296462 citedByCount "0" @default.
- W4385296462 crossrefType "journal-article" @default.
- W4385296462 hasAuthorship W4385296462A5017565565 @default.
- W4385296462 hasAuthorship W4385296462A5025241271 @default.
- W4385296462 hasAuthorship W4385296462A5052501867 @default.
- W4385296462 hasAuthorship W4385296462A5068298797 @default.
- W4385296462 hasConcept C104317684 @default.
- W4385296462 hasConcept C119056186 @default.
- W4385296462 hasConcept C126322002 @default.
- W4385296462 hasConcept C127561419 @default.
- W4385296462 hasConcept C145059251 @default.
- W4385296462 hasConcept C185592680 @default.
- W4385296462 hasConcept C2778997737 @default.
- W4385296462 hasConcept C2781080636 @default.
- W4385296462 hasConcept C502942594 @default.
- W4385296462 hasConcept C509974204 @default.
- W4385296462 hasConcept C55493867 @default.
- W4385296462 hasConcept C62112901 @default.
- W4385296462 hasConcept C62478195 @default.
- W4385296462 hasConcept C71924100 @default.
- W4385296462 hasConcept C76419328 @default.
- W4385296462 hasConcept C86803240 @default.
- W4385296462 hasConcept C95444343 @default.
- W4385296462 hasConceptScore W4385296462C104317684 @default.
- W4385296462 hasConceptScore W4385296462C119056186 @default.
- W4385296462 hasConceptScore W4385296462C126322002 @default.
- W4385296462 hasConceptScore W4385296462C127561419 @default.
- W4385296462 hasConceptScore W4385296462C145059251 @default.
- W4385296462 hasConceptScore W4385296462C185592680 @default.
- W4385296462 hasConceptScore W4385296462C2778997737 @default.
- W4385296462 hasConceptScore W4385296462C2781080636 @default.
- W4385296462 hasConceptScore W4385296462C502942594 @default.
- W4385296462 hasConceptScore W4385296462C509974204 @default.
- W4385296462 hasConceptScore W4385296462C55493867 @default.
- W4385296462 hasConceptScore W4385296462C62112901 @default.
- W4385296462 hasConceptScore W4385296462C62478195 @default.
- W4385296462 hasConceptScore W4385296462C71924100 @default.
- W4385296462 hasConceptScore W4385296462C76419328 @default.
- W4385296462 hasConceptScore W4385296462C86803240 @default.
- W4385296462 hasConceptScore W4385296462C95444343 @default.
- W4385296462 hasIssue "4" @default.
- W4385296462 hasLocation W43852964621 @default.
- W4385296462 hasLocation W43852964622 @default.
- W4385296462 hasOpenAccess W4385296462 @default.
- W4385296462 hasPrimaryLocation W43852964621 @default.
- W4385296462 hasRelatedWork W2026936876 @default.
- W4385296462 hasRelatedWork W2170413290 @default.
- W4385296462 hasRelatedWork W2349233961 @default.
- W4385296462 hasRelatedWork W2370948200 @default.
- W4385296462 hasRelatedWork W2376327684 @default.
- W4385296462 hasRelatedWork W2376888776 @default.
- W4385296462 hasRelatedWork W2741129234 @default.
- W4385296462 hasRelatedWork W3023095530 @default.
- W4385296462 hasRelatedWork W4362480766 @default.
- W4385296462 hasRelatedWork W4362480788 @default.
- W4385296462 hasVolume "102" @default.
- W4385296462 isParatext "false" @default.
- W4385296462 isRetracted "false" @default.
- W4385296462 workType "article" @default.