Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385297303> ?p ?o ?g. }
- W4385297303 endingPage "37289" @default.
- W4385297303 startingPage "37274" @default.
- W4385297303 abstract "We report a one-pot plasma electrolytic oxidation (PEO) strategy for forming a multi-element oxide layer on the titanium surface using complex electrolytes containing Na2HPO4, Ca(OH)2, (NH2)2CO, Na2SiO3, CuSO4, and KOH compounds. For even better bone implant ingrowth, PEO coatings were additionally loaded with bone morphogenetic protein-2 (BMP-2). The samples were tested in vivo in a mouse craniotomy model. Tests for bactericidal and fungicidal activity were carried out using clinically isolated multi-drug-resistant Escherichia coli (E. coli) K261, E. coli U20, methicillin-resistant Staphylococcus aureus (S. aureus) CSA154 bacterial strains, and Neurospora crassa (N. crassa) and Candida albicans (C. albicans) D2528/20 fungi. The PEO-Cu coating effectively inactivated both Gram-positive and Gram-negative bacteria at low concentrations of Cu2+ ions: minimal bactericidal concentration for E. coli and N. crassa (99.9999%) and minimal inhibitory concentration (99.0%) for S. aureus were 5 ppm. For all studied bacterial and fungal strains, PEO-Cu coating completely prevented the formation of bacterial and fungal biofilms. PEO and PEO-Cu coatings demonstrated bone remodeling and moderate osteoconductivity in vivo, while BMP-2 significantly enhanced osteoconduction and osteogenesis. The obtained results are encouraging and indicate that Ti-based materials with PEO coatings loaded with BMP-2 can be widely used in customized medicine as implants for orthopedics and cranio-maxillofacial surgery." @default.
- W4385297303 created "2023-07-28" @default.
- W4385297303 creator A5000583984 @default.
- W4385297303 creator A5008674261 @default.
- W4385297303 creator A5009014656 @default.
- W4385297303 creator A5013984279 @default.
- W4385297303 creator A5019487567 @default.
- W4385297303 creator A5027774145 @default.
- W4385297303 creator A5029270066 @default.
- W4385297303 creator A5033343340 @default.
- W4385297303 creator A5042576479 @default.
- W4385297303 creator A5044587406 @default.
- W4385297303 creator A5052952521 @default.
- W4385297303 creator A5054734420 @default.
- W4385297303 creator A5063396354 @default.
- W4385297303 creator A5067621703 @default.
- W4385297303 creator A5074641896 @default.
- W4385297303 creator A5086009175 @default.
- W4385297303 creator A5092551263 @default.
- W4385297303 date "2023-07-27" @default.
- W4385297303 modified "2023-10-01" @default.
- W4385297303 title "Osteoconductive, Osteogenic, and Antipathogenic Plasma Electrolytic Oxidation Coatings on Titanium Implants with BMP-2" @default.
- W4385297303 cites W1970026642 @default.
- W4385297303 cites W1980244688 @default.
- W4385297303 cites W2014560762 @default.
- W4385297303 cites W2022386776 @default.
- W4385297303 cites W2033410003 @default.
- W4385297303 cites W2039376148 @default.
- W4385297303 cites W2041157237 @default.
- W4385297303 cites W2046119439 @default.
- W4385297303 cites W2065699992 @default.
- W4385297303 cites W2085365047 @default.
- W4385297303 cites W2121269537 @default.
- W4385297303 cites W2186061346 @default.
- W4385297303 cites W2299283281 @default.
- W4385297303 cites W2299421639 @default.
- W4385297303 cites W2339255259 @default.
- W4385297303 cites W2437376282 @default.
- W4385297303 cites W2491292058 @default.
- W4385297303 cites W2510118916 @default.
- W4385297303 cites W2517559575 @default.
- W4385297303 cites W2587818149 @default.
- W4385297303 cites W2606254366 @default.
- W4385297303 cites W2612369154 @default.
- W4385297303 cites W2613375846 @default.
- W4385297303 cites W2615905835 @default.
- W4385297303 cites W2748215620 @default.
- W4385297303 cites W2753836924 @default.
- W4385297303 cites W2765364992 @default.
- W4385297303 cites W2776148448 @default.
- W4385297303 cites W2802328524 @default.
- W4385297303 cites W2803007964 @default.
- W4385297303 cites W2805723146 @default.
- W4385297303 cites W2806939891 @default.
- W4385297303 cites W2903931082 @default.
- W4385297303 cites W2904386673 @default.
- W4385297303 cites W2908418786 @default.
- W4385297303 cites W2922171839 @default.
- W4385297303 cites W292766764 @default.
- W4385297303 cites W2965206016 @default.
- W4385297303 cites W2965295081 @default.
- W4385297303 cites W2965676333 @default.
- W4385297303 cites W2967723341 @default.
- W4385297303 cites W2979935892 @default.
- W4385297303 cites W2985291167 @default.
- W4385297303 cites W2996584703 @default.
- W4385297303 cites W2997426990 @default.
- W4385297303 cites W3000473592 @default.
- W4385297303 cites W3007658841 @default.
- W4385297303 cites W3008871643 @default.
- W4385297303 cites W3011865262 @default.
- W4385297303 cites W3025251531 @default.
- W4385297303 cites W3028376725 @default.
- W4385297303 cites W3034724172 @default.
- W4385297303 cites W3035481425 @default.
- W4385297303 cites W3039631658 @default.
- W4385297303 cites W3041311062 @default.
- W4385297303 cites W3047549865 @default.
- W4385297303 cites W3088785585 @default.
- W4385297303 cites W3111615740 @default.
- W4385297303 cites W3114271074 @default.
- W4385297303 cites W3134896644 @default.
- W4385297303 cites W3160769215 @default.
- W4385297303 cites W3165745957 @default.
- W4385297303 cites W3170515631 @default.
- W4385297303 cites W3184274636 @default.
- W4385297303 cites W3210830446 @default.
- W4385297303 cites W3215945321 @default.
- W4385297303 cites W4206032792 @default.
- W4385297303 cites W4206914566 @default.
- W4385297303 cites W4220777576 @default.
- W4385297303 cites W4220901903 @default.
- W4385297303 cites W4320525625 @default.
- W4385297303 cites W4320912398 @default.
- W4385297303 cites W4365135720 @default.
- W4385297303 doi "https://doi.org/10.1021/acsami.3c08954" @default.
- W4385297303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37499236" @default.
- W4385297303 hasPublicationYear "2023" @default.