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- W4385297980 abstract "The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show that HIF-1α protein levels transiently increase during the G1 phase of the cell cycle (designated as G1-HIF) in an AMP-activated protein kinase (AMPK)-dependent manner. The transient elimination of G1-HIF by a degron system revealed its contribution to cell survival under unfavorable metabolic conditions. Indeed, G1-HIF plays a key role in the cell cycle-dependent expression of genes encoding metabolic regulators and the maintenance of mTOR activity under conditions of nutrient deprivation. Accordingly, transient elimination of G1-HIF led to a significant reduction in the concentration of key proteinogenic amino acids and carbohydrates. These data indicate that G1-HIF acts as a cell cycle-dependent surveillance factor that prevents the onset of starvation-induced apoptosis." @default.
- W4385297980 created "2023-07-28" @default.
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- W4385297980 date "2023-07-27" @default.
- W4385297980 modified "2023-10-11" @default.
- W4385297980 title "A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress" @default.
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- W4385297980 doi "https://doi.org/10.1038/s41419-023-06012-7" @default.
- W4385297980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37500648" @default.
- W4385297980 hasPublicationYear "2023" @default.
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