FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385301812> ?p ?o ?g. }

• W4385301812 abstract "Purpose The incidence of primary liver cancer is increasing year by year, with environmental factors playing a non-negligible role. At present, many studies are still disputing whether air pollution is associated with primary liver cancer incidence, and it is difficult to draw causal inferences. Therefore, in this study, we used two-sample Mendelian randomization (MR) to assess the causal relationship between air pollution (including PM2.5, PM2.5–10, PM10, nitrogen dioxide and nitrogen oxides) and primary liver cancer risk and its related biomarkers (Alpha-fetoprotein, Osteopontin, Glypican-3 and Arginase-1). Patients and methods We used large-scale publicly available genome-wide association studies (GWAS) summary data to conduct MR analyses of European and East Asian populations. Inverse variance weighted (IVW) method was used as the main analysis method, and weighted median model, MR-Egger, simple model and weighted model methods were selected for quality control. Heterogeneity was checked by the Cochran’s Q test. The MR-Egger regression and the MR-PRESSO global test detect pleiotropy. The sensitivity analysis was performed using the leave-one-out method. Results Between air pollution and primary liver cancer in either European (PM2.5: p = 0.993; PM2.5–10: p = 0.833; PM10: p = 0.257; nitrogen dioxide: p = 0.215; nitrogen oxides: p = 0.614) or East Asian (PM2.5: p = 0.718; PM2.5–10: p = 0.362; PM10: p = 0.720; nitrogen dioxide: p = 0.101; nitrogen oxides: p = 0.760) populations were found no statistical association. Notably, there was a causal relationship between nitrogen oxides and Arginase-1, a biomarker associated with hepatocellular differentiation, statistically significant associations remained after deletion for single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency, Body mass index (BMI) and cancers (Beta: 4.46; 95%CI: 0.83–8.08; p = 0.015). There was no heterogeneity or pleiotropy in the results. Conclusion This MR study found no evidence to support a causality between air pollution and primary liver cancer in European and East Asian populations, but nitrogen oxides may affect hepatocellular differentiation." @default.
• W4385301812 created "2023-07-28" @default.
• W4385301812 creator A5038351063 @default.
• W4385301812 creator A5054218510 @default.
• W4385301812 creator A5057557897 @default.
• W4385301812 creator A5059155659 @default.
• W4385301812 creator A5061543595 @default.
• W4385301812 creator A5081093007 @default.
• W4385301812 date "2023-07-27" @default.
• W4385301812 modified "2023-10-16" @default.
• W4385301812 title "Association between air pollution and primary liver cancer in European and east Asian populations: a Mendelian randomization study" @default.
• W4385301812 cites W1905058580 @default.
• W4385301812 cites W1987093317 @default.
• W4385301812 cites W1996295305 @default.
• W4385301812 cites W1997530857 @default.
• W4385301812 cites W2000307707 @default.
• W4385301812 cites W2003989043 @default.
• W4385301812 cites W2008214282 @default.
• W4385301812 cites W2011148132 @default.
• W4385301812 cites W2015932865 @default.
• W4385301812 cites W2034870095 @default.
• W4385301812 cites W2045920795 @default.
• W4385301812 cites W2066544083 @default.
• W4385301812 cites W2082704080 @default.
• W4385301812 cites W2090747780 @default.
• W4385301812 cites W2107450322 @default.
• W4385301812 cites W2120081385 @default.
• W4385301812 cites W2125236475 @default.
• W4385301812 cites W2127768736 @default.
• W4385301812 cites W2134729107 @default.
• W4385301812 cites W2154724379 @default.
• W4385301812 cites W2157043395 @default.
• W4385301812 cites W2170845559 @default.
• W4385301812 cites W2176258934 @default.
• W4385301812 cites W2508534964 @default.
• W4385301812 cites W2566116513 @default.
• W4385301812 cites W2576176197 @default.
• W4385301812 cites W2581245397 @default.
• W4385301812 cites W2583272461 @default.
• W4385301812 cites W2592872345 @default.
• W4385301812 cites W2607350314 @default.
• W4385301812 cites W2622945434 @default.
• W4385301812 cites W2738533345 @default.
• W4385301812 cites W2802963542 @default.
• W4385301812 cites W2803072880 @default.
• W4385301812 cites W2805712258 @default.
• W4385301812 cites W2805983714 @default.
• W4385301812 cites W2889646458 @default.
• W4385301812 cites W2895486342 @default.
• W4385301812 cites W2916940329 @default.
• W4385301812 cites W2953121869 @default.
• W4385301812 cites W2980031238 @default.
• W4385301812 cites W2992080212 @default.
• W4385301812 cites W3014583391 @default.
• W4385301812 cites W3021610682 @default.
• W4385301812 cites W3022387787 @default.
• W4385301812 cites W3045496292 @default.
• W4385301812 cites W3092295420 @default.
• W4385301812 cites W3113104574 @default.
• W4385301812 cites W3134327270 @default.
• W4385301812 cites W3183249095 @default.
• W4385301812 cites W3211635950 @default.
• W4385301812 cites W4282934438 @default.
• W4385301812 cites W4289938447 @default.
• W4385301812 cites W4317390883 @default.
• W4385301812 cites W4318824134 @default.
• W4385301812 cites W4319298258 @default.
• W4385301812 doi "https://doi.org/10.3389/fpubh.2023.1212301" @default.
• W4385301812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37575092" @default.
• W4385301812 hasPublicationYear "2023" @default.
• W4385301812 type Work @default.
• W4385301812 citedByCount "0" @default.
• W4385301812 crossrefType "journal-article" @default.
• W4385301812 hasAuthorship W4385301812A5038351063 @default.
• W4385301812 hasAuthorship W4385301812A5054218510 @default.
• W4385301812 hasAuthorship W4385301812A5057557897 @default.
• W4385301812 hasAuthorship W4385301812A5059155659 @default.
• W4385301812 hasAuthorship W4385301812A5061543595 @default.
• W4385301812 hasAuthorship W4385301812A5081093007 @default.
• W4385301812 hasBestOaLocation W43853018121 @default.
• W4385301812 hasConcept C104317684 @default.
• W4385301812 hasConcept C106208931 @default.
• W4385301812 hasConcept C121608353 @default.
• W4385301812 hasConcept C126322002 @default.
• W4385301812 hasConcept C135763542 @default.
• W4385301812 hasConcept C143998085 @default.
• W4385301812 hasConcept C153209595 @default.
• W4385301812 hasConcept C2776231280 @default.
• W4385301812 hasConcept C2779901538 @default.
• W4385301812 hasConcept C2993967602 @default.
• W4385301812 hasConcept C54355233 @default.
• W4385301812 hasConcept C71924100 @default.
• W4385301812 hasConcept C86803240 @default.
• W4385301812 hasConcept C99454951 @default.
• W4385301812 hasConceptScore W4385301812C104317684 @default.
• W4385301812 hasConceptScore W4385301812C106208931 @default.
• W4385301812 hasConceptScore W4385301812C121608353 @default.
• W4385301812 hasConceptScore W4385301812C126322002 @default.
• W4385301812 hasConceptScore W4385301812C135763542 @default.
• W4385301812 hasConceptScore W4385301812C143998085 @default.

• next