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- W4385302966 abstract "Malignant tumors have a unique tumor microenvironment (TME), which includes mild acidity, hypoxia, overexpressed reactive oxygen species (ROS), and high glutathione (GSH) levels, among others. Recently, TME regulation approaches have attracted widespread attention in cancer immunotherapy. Nanoparticles as drug delivery systems have ability to modulate the hydrophilicity of drugs to affect drug uptake and efflux in tumor. Especially, the metal nanoparticles have been extensive applied for tumor immunotherapy due to their unique physical properties and elaborate design. However, the potential deficiencies of metal nanoparticles due to their low biodegradability, toxicity and treatment side effects restrict their clinical application. In this review, we briefly introduce the feature characteristics of the TME and the recent advances in tumor microenvironment responsive metal nanoparticles for tumor immunotherapy. In addition, nanoparticles could be combined with other treatments, such as chemotherapy, radiotherapy and photodynamic therapy also is presented. Finally, the challenges and outlook for improving the antitumor immunotherapy efficiency, side effect and potential risks of metal nanoparticles has been discussed." @default.
- W4385302966 created "2023-07-28" @default.
- W4385302966 creator A5007231035 @default.
- W4385302966 creator A5014959458 @default.
- W4385302966 creator A5026551782 @default.
- W4385302966 creator A5049692788 @default.
- W4385302966 creator A5054383087 @default.
- W4385302966 creator A5071074966 @default.
- W4385302966 creator A5078526337 @default.
- W4385302966 date "2023-07-27" @default.
- W4385302966 modified "2023-09-25" @default.
- W4385302966 title "Tumor microenvironment responsive metal nanoparticles in cancer immunotherapy" @default.
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