FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385306517> ?p ?o ?g. }

• W4385306517 endingPage "1495" @default.
• W4385306517 startingPage "1477" @default.
• W4385306517 abstract "Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, representing 40% of all cases of this tumor. Despite immense improvements in understanding the molecular basis, diagnosis, and treatment of LUAD, its recurrence rate is still high.RNA-seq data from The Cancer Genome Atlas (TCGA) LUAD cohort were download from Genomic Data Commons Portal. The GSE13213 dataset from Gene Expression Omnibus (GEO) was used for external validation. Differential prognostic lysosome-related genes (LRGs) were identified by overlapping survival-related genes obtained via univariate Cox regression analysis with differentially expressed genes (DEGs). The prognostic model was built using Kaplan-Meier curves and least absolute shrinkage and selection operator (LASSO) analyses. In addition, univariate and multivariate Cox analyses were employed to identify independent prognostic factors. The responses of patients to immune checkpoint inhibitors (ICIs) were further predicted. The pRRophetic package and rank-sum test were used to compute the half maximal inhibitory concentrations (IC50) of 56 chemotherapeutic drugs and their differential effects in the low- and high-risk groups. Moreover, quantitative real-time polymerase chain reaction, Western blot, and human protein atlas (HPA) database were used to verify the expression of the four prognostic biomarkers in LUAD.Of the nine candidate differential prognostic LRGs, GATA2, TFAP2A, LMBRD1, and KRT8 were selected as prognostic biomarkers. The prediction of the risk model was validated to be reliable. Cox independent prognostic analysis revealed that risk score and stage were independent prognostic factors in LUAD. Furthermore, the nomogram and calibration curves of the independent prognostic factors performed well. Differential analysis of ICIs revealed CD276, ICOS, PDCD1LG2, CD27, TNFRSF18, TNFSF9, ENTPD1, and NT5E to be expressed differently in the low- and high-risk groups. The IC50 values of 12 chemotherapeutic drugs, including epothilone.B, JNK.inhibitor.VIII, and AKT.inhibitor.VIII, significantly differed between the two risk groups. KRT8 and TFAP2A were highly expressed, while GATA2 and LMBRD1 were poorly expressed in LUAD cell lines. In addition, KRT8 and TFAP2A were highly expressed, while GATA2 and LMBRD1 were poorly expressed in tumor tissues.Four key prognostic biomarkers-GATA2, TFAP2A, LMBRD1, and KRT8-were used to construct a significant prognostic model for LUAD patients." @default.
• W4385306517 created "2023-07-28" @default.
• W4385306517 creator A5011186506 @default.
• W4385306517 creator A5020147975 @default.
• W4385306517 creator A5024862149 @default.
• W4385306517 creator A5026050036 @default.
• W4385306517 creator A5029360035 @default.
• W4385306517 creator A5046363445 @default.
• W4385306517 creator A5048812286 @default.
• W4385306517 creator A5049067455 @default.
• W4385306517 creator A5068549585 @default.
• W4385306517 creator A5078141810 @default.
• W4385306517 date "2023-07-01" @default.
• W4385306517 modified "2023-09-26" @default.
• W4385306517 title "Identification of lysosomal genes associated with prognosis in lung adenocarcinoma" @default.
• W4385306517 cites W1596198528 @default.
• W4385306517 cites W1860599747 @default.
• W4385306517 cites W1970260762 @default.
• W4385306517 cites W1997407692 @default.
• W4385306517 cites W1997791083 @default.
• W4385306517 cites W2034683251 @default.
• W4385306517 cites W2042678758 @default.
• W4385306517 cites W2047056561 @default.
• W4385306517 cites W2086631242 @default.
• W4385306517 cites W2099900951 @default.
• W4385306517 cites W2111481682 @default.
• W4385306517 cites W2117569715 @default.
• W4385306517 cites W2117692326 @default.
• W4385306517 cites W2118598201 @default.
• W4385306517 cites W2126489732 @default.
• W4385306517 cites W2138826259 @default.
• W4385306517 cites W2142280970 @default.
• W4385306517 cites W2146512944 @default.
• W4385306517 cites W2166749501 @default.
• W4385306517 cites W2253187313 @default.
• W4385306517 cites W2466033276 @default.
• W4385306517 cites W2551607099 @default.
• W4385306517 cites W2742635485 @default.
• W4385306517 cites W2761081415 @default.
• W4385306517 cites W2809000676 @default.
• W4385306517 cites W2893229904 @default.
• W4385306517 cites W2903397393 @default.
• W4385306517 cites W2911122280 @default.
• W4385306517 cites W2911831872 @default.
• W4385306517 cites W2912418732 @default.
• W4385306517 cites W2920340796 @default.
• W4385306517 cites W2943793962 @default.
• W4385306517 cites W2945858728 @default.
• W4385306517 cites W2956900731 @default.
• W4385306517 cites W2999130863 @default.
• W4385306517 cites W3009145316 @default.
• W4385306517 cites W3009671354 @default.
• W4385306517 cites W3033189487 @default.
• W4385306517 cites W3108737349 @default.
• W4385306517 cites W3128646645 @default.
• W4385306517 cites W3131124811 @default.
• W4385306517 cites W3139802259 @default.
• W4385306517 cites W3159595144 @default.
• W4385306517 cites W3162818643 @default.
• W4385306517 cites W3175752499 @default.
• W4385306517 cites W4280577669 @default.
• W4385306517 cites W4284888408 @default.
• W4385306517 doi "https://doi.org/10.21037/tlcr-23-14" @default.
• W4385306517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37577321" @default.
• W4385306517 hasPublicationYear "2023" @default.
• W4385306517 type Work @default.
• W4385306517 citedByCount "0" @default.
• W4385306517 crossrefType "journal-article" @default.
• W4385306517 hasAuthorship W4385306517A5011186506 @default.
• W4385306517 hasAuthorship W4385306517A5020147975 @default.
• W4385306517 hasAuthorship W4385306517A5024862149 @default.
• W4385306517 hasAuthorship W4385306517A5026050036 @default.
• W4385306517 hasAuthorship W4385306517A5029360035 @default.
• W4385306517 hasAuthorship W4385306517A5046363445 @default.
• W4385306517 hasAuthorship W4385306517A5048812286 @default.
• W4385306517 hasAuthorship W4385306517A5049067455 @default.
• W4385306517 hasAuthorship W4385306517A5068549585 @default.
• W4385306517 hasAuthorship W4385306517A5078141810 @default.
• W4385306517 hasBestOaLocation W43853065171 @default.
• W4385306517 hasConcept C10515644 @default.
• W4385306517 hasConcept C119857082 @default.
• W4385306517 hasConcept C121608353 @default.
• W4385306517 hasConcept C126322002 @default.
• W4385306517 hasConcept C143998085 @default.
• W4385306517 hasConcept C161584116 @default.
• W4385306517 hasConcept C199163554 @default.
• W4385306517 hasConcept C2776256026 @default.
• W4385306517 hasConcept C2781182431 @default.
• W4385306517 hasConcept C34626388 @default.
• W4385306517 hasConcept C41008148 @default.
• W4385306517 hasConcept C50382708 @default.
• W4385306517 hasConcept C60644358 @default.
• W4385306517 hasConcept C70721500 @default.
• W4385306517 hasConcept C71924100 @default.
• W4385306517 hasConcept C86803240 @default.
• W4385306517 hasConceptScore W4385306517C10515644 @default.
• W4385306517 hasConceptScore W4385306517C119857082 @default.
• W4385306517 hasConceptScore W4385306517C121608353 @default.

• next