Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385308093> ?p ?o ?g. }
- W4385308093 abstract "Abstract RAD54L is a DNA motor protein with critical roles in homologous recombination DNA repair (HR). In vitro , RAD54L was also shown to catalyze the reversal and restoration of model replication forks. Little, however, is known about the role of RAD54L in regulating the dynamics of DNA replication in cells. Here, we show that RAD54L functions as a fork remodeler and restrains the progression of replication forks in human cells. Analogous to HLTF and FBH1, and consistent with a role in fork reversal, RAD54L catalyzes the slowing of fork progression in response to replication stress. In BRCA1/2-deficient cells, RAD54L activity leads to nascent strand DNA degradation, and loss of RAD54L reduces DNA double-strand break formation. Using a separation-of-function mutation, we show that RAD54L-mediated fork restraint depends on its ability to catalyze branch migration. Our results reveal a new role for RAD54L in regulating the dynamics of replication forks in cells and highlight the impact of RAD54L function on the treatment of patients with BRCA1/2-deficient tumors." @default.
- W4385308093 created "2023-07-28" @default.
- W4385308093 creator A5048574811 @default.
- W4385308093 creator A5051127442 @default.
- W4385308093 creator A5076452654 @default.
- W4385308093 creator A5085609944 @default.
- W4385308093 creator A5088902115 @default.
- W4385308093 date "2023-07-27" @default.
- W4385308093 modified "2023-09-29" @default.
- W4385308093 title "RAD54L regulates replication fork progression and nascent strand degradation in BRCA1/2-deficient cells" @default.
- W4385308093 cites W1521943738 @default.
- W4385308093 cites W1676891985 @default.
- W4385308093 cites W1873662011 @default.
- W4385308093 cites W1896395394 @default.
- W4385308093 cites W1964993093 @default.
- W4385308093 cites W1970578083 @default.
- W4385308093 cites W1981258136 @default.
- W4385308093 cites W1989388273 @default.
- W4385308093 cites W1997863177 @default.
- W4385308093 cites W2004867792 @default.
- W4385308093 cites W2006895915 @default.
- W4385308093 cites W2009007206 @default.
- W4385308093 cites W2009851230 @default.
- W4385308093 cites W2017988777 @default.
- W4385308093 cites W2023257987 @default.
- W4385308093 cites W2029023135 @default.
- W4385308093 cites W2038493035 @default.
- W4385308093 cites W2042461423 @default.
- W4385308093 cites W2047504175 @default.
- W4385308093 cites W2053417989 @default.
- W4385308093 cites W2055980504 @default.
- W4385308093 cites W2060993163 @default.
- W4385308093 cites W2062739292 @default.
- W4385308093 cites W2066883074 @default.
- W4385308093 cites W2076024644 @default.
- W4385308093 cites W2077227904 @default.
- W4385308093 cites W2096333191 @default.
- W4385308093 cites W2096380982 @default.
- W4385308093 cites W2104584181 @default.
- W4385308093 cites W2111490168 @default.
- W4385308093 cites W2118342658 @default.
- W4385308093 cites W2125600180 @default.
- W4385308093 cites W2133940489 @default.
- W4385308093 cites W2146533600 @default.
- W4385308093 cites W2151318295 @default.
- W4385308093 cites W2166219476 @default.
- W4385308093 cites W2170725518 @default.
- W4385308093 cites W2409391306 @default.
- W4385308093 cites W2610738034 @default.
- W4385308093 cites W2737658553 @default.
- W4385308093 cites W2751450140 @default.
- W4385308093 cites W2762278714 @default.
- W4385308093 cites W2763077107 @default.
- W4385308093 cites W2763248055 @default.
- W4385308093 cites W2765875601 @default.
- W4385308093 cites W2776411615 @default.
- W4385308093 cites W2810748925 @default.
- W4385308093 cites W2852866740 @default.
- W4385308093 cites W2923629362 @default.
- W4385308093 cites W2955745836 @default.
- W4385308093 cites W2975632694 @default.
- W4385308093 cites W3026131189 @default.
- W4385308093 cites W3033655624 @default.
- W4385308093 cites W3039743046 @default.
- W4385308093 cites W3041183674 @default.
- W4385308093 cites W3042118153 @default.
- W4385308093 cites W3043743907 @default.
- W4385308093 cites W3049398524 @default.
- W4385308093 cites W3082767637 @default.
- W4385308093 cites W3102726164 @default.
- W4385308093 cites W3113025221 @default.
- W4385308093 cites W3131560631 @default.
- W4385308093 cites W3160242511 @default.
- W4385308093 cites W4220864127 @default.
- W4385308093 cites W4280550556 @default.
- W4385308093 cites W4283012954 @default.
- W4385308093 cites W4313409018 @default.
- W4385308093 cites W4318069007 @default.
- W4385308093 cites W4367173662 @default.
- W4385308093 doi "https://doi.org/10.1101/2023.07.26.550704" @default.
- W4385308093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37546955" @default.
- W4385308093 hasPublicationYear "2023" @default.
- W4385308093 type Work @default.
- W4385308093 citedByCount "1" @default.
- W4385308093 countsByYear W43853080932023 @default.
- W4385308093 crossrefType "posted-content" @default.
- W4385308093 hasAuthorship W4385308093A5048574811 @default.
- W4385308093 hasAuthorship W4385308093A5051127442 @default.
- W4385308093 hasAuthorship W4385308093A5076452654 @default.
- W4385308093 hasAuthorship W4385308093A5085609944 @default.
- W4385308093 hasAuthorship W4385308093A5088902115 @default.
- W4385308093 hasBestOaLocation W43853080931 @default.
- W4385308093 hasConcept C102744134 @default.
- W4385308093 hasConcept C104317684 @default.
- W4385308093 hasConcept C104690221 @default.
- W4385308093 hasConcept C111919701 @default.
- W4385308093 hasConcept C12590798 @default.
- W4385308093 hasConcept C13052165 @default.
- W4385308093 hasConcept C134935766 @default.
- W4385308093 hasConcept C159047783 @default.