Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385309777> ?p ?o ?g. }
- W4385309777 endingPage "11975" @default.
- W4385309777 startingPage "11975" @default.
- W4385309777 abstract "Osteosarcoma (OS) is an aggressive tumor with a rare incidence. Extended surgical resections are the prevalent treatment for OS, which may cause critical-size bone defects. These bone defects lead to dysfunction, weakening the post-surgical quality of patients’ life. Hence, an ideal therapeutic agent for OS should simultaneously possess anti-cancer and bone repair capacities. Curcumin (CUR) has been reported in OS therapy and bone regeneration. However, it is not clear how CUR suppresses OS development. Conventionally, CUR is considered a natural antioxidant in line with its capacity to promote the nuclear translocation of a nuclear transcription factor, nuclear factor erythroid 2 (NRF2). After nuclear translocation, NRF2 can activate the transcription of some antioxidases, thereby circumventing excess reactive oxygen species (ROS) that are deleterious to cells. Intriguingly, this research demonstrated that, in vitro, 10 and 20 μM CUR increased the intracellular ROS in MG-63 cells, damaged cells’ DNA, and finally caused apoptosis of MG-63 cells, although increased NRF2 protein level and the expression of NRF2-regulated antioxidase genes were identified in those two groups." @default.
- W4385309777 created "2023-07-28" @default.
- W4385309777 creator A5017191784 @default.
- W4385309777 creator A5027619452 @default.
- W4385309777 creator A5028858641 @default.
- W4385309777 creator A5031458721 @default.
- W4385309777 creator A5032088462 @default.
- W4385309777 date "2023-07-26" @default.
- W4385309777 modified "2023-10-14" @default.
- W4385309777 title "Paradox: Curcumin, a Natural Antioxidant, Suppresses Osteosarcoma Cells via Excessive Reactive Oxygen Species" @default.
- W4385309777 cites W1569904453 @default.
- W4385309777 cites W1826487857 @default.
- W4385309777 cites W1966571906 @default.
- W4385309777 cites W1972179974 @default.
- W4385309777 cites W1976599392 @default.
- W4385309777 cites W1977920395 @default.
- W4385309777 cites W1980088710 @default.
- W4385309777 cites W1988325237 @default.
- W4385309777 cites W2045959886 @default.
- W4385309777 cites W2103454592 @default.
- W4385309777 cites W2105112975 @default.
- W4385309777 cites W2140126848 @default.
- W4385309777 cites W2144491599 @default.
- W4385309777 cites W2146558971 @default.
- W4385309777 cites W2254116682 @default.
- W4385309777 cites W2286748995 @default.
- W4385309777 cites W2395626624 @default.
- W4385309777 cites W2570580727 @default.
- W4385309777 cites W2621333085 @default.
- W4385309777 cites W2749151718 @default.
- W4385309777 cites W2799290037 @default.
- W4385309777 cites W2895984177 @default.
- W4385309777 cites W2928820811 @default.
- W4385309777 cites W2947977317 @default.
- W4385309777 cites W2952135531 @default.
- W4385309777 cites W2957289901 @default.
- W4385309777 cites W2960698964 @default.
- W4385309777 cites W2972309751 @default.
- W4385309777 cites W2975629170 @default.
- W4385309777 cites W2978605903 @default.
- W4385309777 cites W3001161839 @default.
- W4385309777 cites W3015784228 @default.
- W4385309777 cites W3119175192 @default.
- W4385309777 cites W3119799492 @default.
- W4385309777 cites W3124357598 @default.
- W4385309777 cites W3156585317 @default.
- W4385309777 cites W3157638995 @default.
- W4385309777 cites W3160528090 @default.
- W4385309777 cites W3185569496 @default.
- W4385309777 cites W3192426138 @default.
- W4385309777 cites W3210065931 @default.
- W4385309777 cites W3210369254 @default.
- W4385309777 cites W4221062978 @default.
- W4385309777 cites W4235565063 @default.
- W4385309777 cites W4237785667 @default.
- W4385309777 cites W4249201955 @default.
- W4385309777 cites W4307657001 @default.
- W4385309777 cites W4312143430 @default.
- W4385309777 cites W4312216606 @default.
- W4385309777 cites W4315607850 @default.
- W4385309777 cites W4379471788 @default.
- W4385309777 cites W4380225119 @default.
- W4385309777 doi "https://doi.org/10.3390/ijms241511975" @default.
- W4385309777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37569346" @default.
- W4385309777 hasPublicationYear "2023" @default.
- W4385309777 type Work @default.
- W4385309777 citedByCount "0" @default.
- W4385309777 crossrefType "journal-article" @default.
- W4385309777 hasAuthorship W4385309777A5017191784 @default.
- W4385309777 hasAuthorship W4385309777A5027619452 @default.
- W4385309777 hasAuthorship W4385309777A5028858641 @default.
- W4385309777 hasAuthorship W4385309777A5031458721 @default.
- W4385309777 hasAuthorship W4385309777A5032088462 @default.
- W4385309777 hasBestOaLocation W43853097771 @default.
- W4385309777 hasConcept C104317684 @default.
- W4385309777 hasConcept C143425029 @default.
- W4385309777 hasConcept C185592680 @default.
- W4385309777 hasConcept C190062978 @default.
- W4385309777 hasConcept C190283241 @default.
- W4385309777 hasConcept C2777760704 @default.
- W4385309777 hasConcept C2778004101 @default.
- W4385309777 hasConcept C2778250585 @default.
- W4385309777 hasConcept C2780114586 @default.
- W4385309777 hasConcept C48349386 @default.
- W4385309777 hasConcept C502942594 @default.
- W4385309777 hasConcept C54757728 @default.
- W4385309777 hasConcept C552990157 @default.
- W4385309777 hasConcept C55493867 @default.
- W4385309777 hasConcept C79879829 @default.
- W4385309777 hasConcept C86339819 @default.
- W4385309777 hasConcept C86803240 @default.
- W4385309777 hasConcept C95444343 @default.
- W4385309777 hasConcept C98274493 @default.
- W4385309777 hasConceptScore W4385309777C104317684 @default.
- W4385309777 hasConceptScore W4385309777C143425029 @default.
- W4385309777 hasConceptScore W4385309777C185592680 @default.
- W4385309777 hasConceptScore W4385309777C190062978 @default.
- W4385309777 hasConceptScore W4385309777C190283241 @default.