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- W4385320362 endingPage "3767" @default.
- W4385320362 startingPage "3767" @default.
- W4385320362 abstract "Infection with cytomegalovirus (CMV) is highly prevalent in the general population and largely controlled by CD8pos T cells. Intriguingly, anti-CMV T cells accumulate over time to extraordinarily high numbers, are frequently present as tumor-resident ‘bystander’ T cells, and remain functional in cancer patients. Consequently, various strategies for redirecting anti-CMV CD8pos T cells to eliminate cancer cells are currently being developed. Here, we provide an overview of these strategies including immunogenic CMV peptide-loading onto endogenous HLA complexes on cancer cells and the use of tumor-directed fusion proteins containing a preassembled CMV peptide/HLA-I complex. Additionally, we discuss conveying the advantageous characteristics of anti-CMV T cells in adoptive cell therapy. Utilization of anti-CMV CD8pos T cells to generate CAR T cells promotes their in vivo persistence and expansion due to appropriate co-stimulation through the endogenous (CMV-)TCR signaling complex. Designing TCR-engineered T cells is more challenging, as the artificial and endogenous TCR compete for expression. Moreover, the use of expanded/reactivated anti-CMV T cells to target CMV peptide-expressing glioblastomas is discussed. This review highlights the most important findings and compares the benefits, disadvantages, and challenges of each strategy. Finally, we discuss how anti-CMV T cell therapies can be further improved to enhance treatment efficacy." @default.
- W4385320362 created "2023-07-28" @default.
- W4385320362 creator A5019749108 @default.
- W4385320362 creator A5072705437 @default.
- W4385320362 creator A5091917534 @default.
- W4385320362 date "2023-07-25" @default.
- W4385320362 modified "2023-09-25" @default.
- W4385320362 title "Applications of Anti-Cytomegalovirus T Cells for Cancer (Immuno)Therapy" @default.
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