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• W4385322729 endingPage "88" @default.
• W4385322729 startingPage "75" @default.
• W4385322729 abstract "There is a growing interest for studying the impact of chronic inflammation, particularly lung inflammation, on the brain and behavior. This includes asthma, a chronic inflammatory condition, that has been associated with psychiatric conditions such as posttraumatic stress disorder (PTSD). Although asthma is driven by elevated production of Th2 cytokines (IL-4, IL-5 and IL-13), which drive asthma symptomology, recent work demonstrates that concomitant Th1 or Th17 cytokine production can worsen asthma severity. We previously demonstrated a detrimental link between PTSD-relevant fear behavior and allergen-induced lung inflammation associated with a mixed Th2/Th17-inflammatory profile in mice. However, the behavioral effects of Th2-skewed airway inflammation, typical to mild/moderate asthma, are unknown. Therefore, we investigated fear conditioning/extinction in allergen house dust mite (HDM)-exposed C57Bl/6 mice, a model of Th2-skewed allergic asthma. Behaviors relevant to panic, anxiety, and depression were also assessed. Furthermore, we investigated the accumulation of Th2/Th17-cytokine-expressing cells in lung and brain, and the neuronal activation marker, ΔFosB, in fear regulatory brain areas. HDM-exposed mice elicited lower freezing during fear extinction with no effects on acquisition and conditioned fear. No HDM effect on panic, anxiety or depression-relevant behaviors was observed. While HDM evoked a Th2-skewed immune response in lung tissue, no significant alterations in brain Th cell subsets were observed. Significantly reduced ΔFosB+ cells in the basolateral amygdala of HDM mice were observed post extinction. Our data indicate that allergen-driven Th2-skewed responses may induce fear extinction promoting effects, highlighting beneficial interactions of Th2-associated immune mediators with fear regulatory circuits." @default.
• W4385322729 created "2023-07-28" @default.
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• W4385322729 date "2023-09-01" @default.
• W4385322729 modified "2023-10-17" @default.
• W4385322729 title "Altered fear behavior in aeroallergen house dust mite exposed C57Bl/6 mice: a model of Th2-skewed airway inflammation" @default.
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• W4385322729 cites W1583015538 @default.
• W4385322729 cites W1819601131 @default.
• W4385322729 cites W1969202258 @default.
• W4385322729 cites W1974338321 @default.
• W4385322729 cites W1978310063 @default.
• W4385322729 cites W1981496519 @default.
• W4385322729 cites W1988353820 @default.
• W4385322729 cites W1988757263 @default.
• W4385322729 cites W1990336166 @default.
• W4385322729 cites W1999603992 @default.
• W4385322729 cites W2002405829 @default.
• W4385322729 cites W2013181947 @default.
• W4385322729 cites W2014671181 @default.
• W4385322729 cites W2016944914 @default.
• W4385322729 cites W2020073898 @default.
• W4385322729 cites W2022405720 @default.
• W4385322729 cites W2023262819 @default.
• W4385322729 cites W2042427055 @default.
• W4385322729 cites W2044100668 @default.
• W4385322729 cites W2048395646 @default.
• W4385322729 cites W2052042076 @default.
• W4385322729 cites W2055950408 @default.
• W4385322729 cites W2062367951 @default.
• W4385322729 cites W2062783549 @default.
• W4385322729 cites W2069284368 @default.
• W4385322729 cites W2070273080 @default.
• W4385322729 cites W2083828783 @default.
• W4385322729 cites W2087799178 @default.
• W4385322729 cites W2092780215 @default.
• W4385322729 cites W2110729320 @default.
• W4385322729 cites W2135172357 @default.
• W4385322729 cites W2139775496 @default.
• W4385322729 cites W2142126178 @default.
• W4385322729 cites W2145051681 @default.
• W4385322729 cites W2307859929 @default.
• W4385322729 cites W2366832974 @default.
• W4385322729 cites W2397525421 @default.
• W4385322729 cites W2403674481 @default.
• W4385322729 cites W2510536527 @default.
• W4385322729 cites W2586456604 @default.
• W4385322729 cites W2594488337 @default.
• W4385322729 cites W2600959588 @default.
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• W4385322729 cites W2757748510 @default.
• W4385322729 cites W2889420397 @default.
• W4385322729 cites W2889463056 @default.
• W4385322729 cites W2891051682 @default.
• W4385322729 cites W2900972693 @default.
• W4385322729 cites W2912452740 @default.
• W4385322729 cites W2939247829 @default.
• W4385322729 cites W2959497269 @default.
• W4385322729 cites W2973121903 @default.
• W4385322729 cites W2979994192 @default.
• W4385322729 cites W2988417388 @default.
• W4385322729 cites W2995009185 @default.
• W4385322729 cites W2996484739 @default.
• W4385322729 cites W2996822207 @default.
• W4385322729 cites W3000085439 @default.
• W4385322729 cites W3006023282 @default.
• W4385322729 cites W3008941219 @default.
• W4385322729 cites W3015582409 @default.
• W4385322729 cites W3022989381 @default.
• W4385322729 cites W3023767473 @default.
• W4385322729 cites W3106245707 @default.
• W4385322729 cites W3108711653 @default.
• W4385322729 cites W3109720983 @default.
• W4385322729 cites W3111935414 @default.
• W4385322729 cites W3134224893 @default.
• W4385322729 cites W3169004192 @default.
• W4385322729 cites W3202342090 @default.
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• W4385322729 cites W3212915233 @default.
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• W4385322729 cites W4200238217 @default.
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• W4385322729 cites W4213069165 @default.
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• W4385322729 doi "https://doi.org/10.1016/j.neuroscience.2023.07.022" @default.
• W4385322729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37516435" @default.
• W4385322729 hasPublicationYear "2023" @default.
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