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- W4385324346 abstract "Nowadays, implants and prostheses are widely used to repair damaged tissues or to treat different diseases, but their use is associated with the risk of infection, inflammation and finally rejection. To address these issues, new antimicrobial and anti-inflammatory materials are being developed. Aforementioned materials require their thorough preclinical testing before clinical applications can be envisaged. Although many researchers are currently working on new in vitro tissues for drug screening and tissue replacement, in vitro models for evaluation of new biomaterials are just emerging and are extremely rare. In this context, there is an increased need for advanced in vitro models, which would best recapitulate the in vivo environment, limiting animal experimentation and adapted to the multitude of these materials. Here, we overview currently available preclinical methods and models for biological in vitro evaluation of new biomaterials. We describe several biological tests used in biocompatibility assessment, which is a primordial step in new material's development, and discuss existing challenges in this field. In the second part, the emphasis is made on the development of new 3D models and approaches for preclinical evaluation of biomaterials. The third part focuses on the main parameters to consider to achieve the optimal conditions for evaluating biocompatibility; we also overview differences in regulations across different geographical regions and regulatory systems. Finally, we discuss future directions for the development of innovative biomaterial-related assays: in silico models, dynamic testing models, complex multicellular and multiple organ systems, as well as patient-specific personalized testing approaches." @default.
- W4385324346 created "2023-07-28" @default.
- W4385324346 creator A5011830637 @default.
- W4385324346 creator A5026890553 @default.
- W4385324346 creator A5034644352 @default.
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- W4385324346 creator A5064789382 @default.
- W4385324346 creator A5070873329 @default.
- W4385324346 creator A5092556626 @default.
- W4385324346 date "2023-07-27" @default.
- W4385324346 modified "2023-10-18" @default.
- W4385324346 title "Preclinical in vitro evaluation of implantable materials: conventional approaches, new models and future directions" @default.
- W4385324346 cites W1719375567 @default.
- W4385324346 cites W1737029134 @default.
- W4385324346 cites W1995063875 @default.
- W4385324346 cites W2005156172 @default.
- W4385324346 cites W2016578709 @default.
- W4385324346 cites W2030921111 @default.
- W4385324346 cites W2061289138 @default.
- W4385324346 cites W2064270231 @default.
- W4385324346 cites W2067424688 @default.
- W4385324346 cites W2075359954 @default.
- W4385324346 cites W2100784820 @default.
- W4385324346 cites W2103743650 @default.
- W4385324346 cites W2112594043 @default.
- W4385324346 cites W2112767499 @default.
- W4385324346 cites W2115504474 @default.
- W4385324346 cites W2140353364 @default.
- W4385324346 cites W2182798903 @default.
- W4385324346 cites W2264165696 @default.
- W4385324346 cites W2265970762 @default.
- W4385324346 cites W2481424576 @default.
- W4385324346 cites W2485787595 @default.
- W4385324346 cites W2508201086 @default.
- W4385324346 cites W2575772876 @default.
- W4385324346 cites W2592704774 @default.
- W4385324346 cites W2621851868 @default.
- W4385324346 cites W2755744785 @default.
- W4385324346 cites W2766537048 @default.
- W4385324346 cites W2769825685 @default.
- W4385324346 cites W2790621084 @default.
- W4385324346 cites W2791017844 @default.
- W4385324346 cites W2793834265 @default.
- W4385324346 cites W2793849396 @default.
- W4385324346 cites W2794400808 @default.
- W4385324346 cites W2804707443 @default.
- W4385324346 cites W2805004552 @default.
- W4385324346 cites W2807242060 @default.
- W4385324346 cites W2807305159 @default.
- W4385324346 cites W2808125509 @default.
- W4385324346 cites W2810325905 @default.
- W4385324346 cites W2884780408 @default.
- W4385324346 cites W2898519775 @default.
- W4385324346 cites W2900384952 @default.
- W4385324346 cites W2903718141 @default.
- W4385324346 cites W2915619129 @default.
- W4385324346 cites W2947092447 @default.
- W4385324346 cites W2956028362 @default.
- W4385324346 cites W2960775204 @default.
- W4385324346 cites W2962385729 @default.
- W4385324346 cites W2975652314 @default.
- W4385324346 cites W2980790049 @default.
- W4385324346 cites W2990214967 @default.
- W4385324346 cites W3000741476 @default.
- W4385324346 cites W3009670898 @default.
- W4385324346 cites W3014021096 @default.
- W4385324346 cites W3014413945 @default.
- W4385324346 cites W3027612059 @default.
- W4385324346 cites W3039312673 @default.
- W4385324346 cites W3041238645 @default.
- W4385324346 cites W3044077958 @default.
- W4385324346 cites W3087665501 @default.
- W4385324346 cites W3092209185 @default.
- W4385324346 cites W3109205655 @default.
- W4385324346 cites W3113237787 @default.
- W4385324346 cites W3119067483 @default.
- W4385324346 cites W3119804059 @default.
- W4385324346 cites W3123177379 @default.
- W4385324346 cites W3126348959 @default.
- W4385324346 cites W3127091795 @default.
- W4385324346 cites W3128686698 @default.
- W4385324346 cites W3130772966 @default.
- W4385324346 cites W3134402938 @default.
- W4385324346 cites W3158636380 @default.
- W4385324346 cites W3164199631 @default.
- W4385324346 cites W3164200628 @default.
- W4385324346 cites W3165077239 @default.
- W4385324346 cites W3165416540 @default.
- W4385324346 cites W3177008705 @default.
- W4385324346 cites W3185480489 @default.
- W4385324346 cites W3194323996 @default.
- W4385324346 cites W3196994934 @default.
- W4385324346 cites W3200203875 @default.
- W4385324346 cites W3204392606 @default.
- W4385324346 cites W4200318909 @default.
- W4385324346 cites W4210259501 @default.
- W4385324346 cites W4212799110 @default.
- W4385324346 cites W4226021872 @default.
- W4385324346 cites W4286586471 @default.