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- W4385324377 abstract "Timely diagnosis of Schistosoma infection, particularly in the early stage is crucial for identifying infected hosts and then taking effective control strategies. Here, metagenomic next-generation sequencing was used to identify pathogen-specific circulating DNAs (cDNAs) in the sera/plasma of New Zealand rabbits infected with S. japonicum, and the identified cDNAs were validated by PCR and qPCR. Loop-mediated isothermal amplification (LAMP)-based CRISPR-Cas12a and recombinase polymerase amplification-based lateral flow strip (RPA-LF) methods combined with the newly identified cDNA were developed to evaluate the potentials for diagnosing murine and human schistosomiasis. The results indicated that twenty-two cDNAs were identified. The developed LAMP-based CRISPR/Cas12a and RPA-LF methods showed a good potential for diagnosing murine or human schistosomiasis as early as 5 days of post-infection with 5 cercariae infection. In a word, S. japonicum specific cDNAs in circulation of infected hosts could be effective biomarkers for detecting Schistosoma infection particularly for early stages." @default.
- W4385324377 created "2023-07-28" @default.
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- W4385324377 date "2023-09-01" @default.
- W4385324377 modified "2023-10-12" @default.
- W4385324377 title "Metagenomic sequencing for identifying pathogen specific circulating DNAs and development of diagnostic methods for Schistosomiasis" @default.
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- W4385324377 doi "https://doi.org/10.1016/j.isci.2023.107495" @default.
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