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• W4385326413 abstract "PURPOSE: Radiation dermatitis (RD) affects up to 85% of patients after radiotherapy for central nervous system or skin neoplasms.1 RD is characterized by erythema, desquamation, necrosis, fibrosis, ulcers, and bleeding.2 The chronicity of the lesions, particularly ulcers, negatively impacts the patient’s quality of life and requires complex surgical management.3,4 Existing models do not assess scalp RD.5 We aimed to characterize a reproducible model of scalp RD in mice. METHOD: Twenty C57BL/6 mice received an x-ray dose of 60 Gy using a 5-mm collimator to a scalp area between the coronal and lambdoid sutures. Mice were followed for 44 days after irradiation and photographed on ten endpoints, with two mice euthanized per endpoint. Scalp tissue was collected immediately after euthanasia. The photographs were analyzed for erythema, desquamation, and ulceration using ImageJ (National Institutes of Health, United States). Slides were stained with H&E, Masson’s trichrome, and immunohistochemistry for CD31 to analyze epidermal thickness, dermal thickness, total skin thickness (TST), fibrosis, and vascularity using ImageScope (Leica Biosystems, Germany) and ImageJ. Welch’s t-tests were performed to compare the variables’ means per endpoint using R version 4.1.2. RESULTS: Erythema appeared on day one and peaked on day 15 (0.17 vs. 0.23 cm2, p<0.05) to progressively disappear by day 37, lasting approximately one month. Desquamation appeared on day 11 and peaked on day 19 (0.081 vs. 0.121 cm2, p>0.05) to progressively disappear by day 37, lasting approximately three weeks. Most ulcers appeared on day 15 and peaked on day 19 (0.024 vs. 0.025 cm2, p>0.05) to disappear by day 23, lasting approximately ten days. The dermal thickness peaked on day 21 (121 vs. 240 μm, p<0.01), while the epidermal thickness (13.11 vs. 170.31 μm, p<0.01) and TST (133 vs. 373.2 μm, p<0.01) peaked on day 23. By day 44, none of the layers had reached their basal thicknesses (epidermis: 13.11 vs. 48.72 μm, p<0.01; dermis: 121.29 vs. 136.49 μm, p<0.05; TST 133.11 vs. 175.73 μm, p<0.01). Dermal fibrosis peaked on day 19 (11% vs. 50%), decreasing to 4.5% on day 44. The average vessel area and average diameter did not change significantly over time. CONCLUSION: Animals developed progressive erythema and desquamation lasting approximately one month after irradiation. The ulcerative area remains stable for approximately ten days. There is a significant thickening of the skin layers, particularly the epidermis. There is a progressive increase in dermal fibrosis that drops below basal measurements after one month, with no changes in vascularity. REFERENCES: 1. Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol. 2012;132(3 Pt 2):985-993. 2. Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis: an overview. Int J Dermatol. 2017;56(9):909-914. 3. Rzepecki A, Birnbaum M, Ohri N, et al. Characterizing the effects of radiation dermatitis on quality of life: A prospective survey-based study. J Am Acad Dermatol. 2022;86(1):161-163. 4. Larson DA. Surgical management of radiated scalp in patients with recurrent glioma. Neurosurgery. 1994;34(6):1105. 5. Huayllani MT, Ruiz-Garcia H, Boczar D, et al. Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury. Ann Plast Surg. 2021." @default.
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• W4385326413 date "2022-10-01" @default.
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• W4385326413 title "Development of a Scalp Radiation Dermatitis Model in Mice" @default.
• W4385326413 doi "https://doi.org/10.1097/01.gox.0000898648.11720.3c" @default.
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