FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385330275> ?p ?o ?g. }

• W4385330275 endingPage "789" @default.
• W4385330275 startingPage "774" @default.
• W4385330275 abstract "In applying bioanalytical approaches, the aim of this study was to determine the toxicity of contaminants derived from a solid waste dumpsite in Calabar (Nigeria), by investigating the alterations of lipid and estrogen signaling pathways in Poeciliopsis lucida hepatocellular carcinoma-1 (PLHC-1) cells and compared to in vivo African catfish (Clarias gariepinus), using polar, nonpolar and elutriate extraction methods. Cells were exposed for 48 hr period to different concentrations of the contaminant extracts. The PLHC-1 cells were evaluated for lipid responses as follows adipoRed assay, retinoid x receptor (rxr), peroxisome proliferator-activated receptor isoforms (ppar-α and γ), estrogen receptor (er-α) and vitellogenin (vtg) transcripts. The lipid signaling activation was also assessed in vivo using C. gariepinus, where hepatic levels of ppar-α were determined at both transcript and functional proteins levels. Data showed variable-, extract type and concentration-specific elevations in mRNA and protein levels for lipidomic and estrogenic effects. These effects were either biphasic at low and high concentrations, depending upon extract type, or concentration-dependent elevations. In general, these toxicological responses may be attributed to soil organic and inorganic contaminants burden previously derived from the dumpsite. Thus, our data demonstrate a unique lipid and endocrine-disruptive chemical (EDC) effects of each soil extract, suggesting multiple and complex contaminant interactions in the environment and biota. Analysis of numerous soil- or sediment-bound contaminants have numerous limitations and cost implications for developing countries. Our approach provides a bioanalytical protocol and endpoints for measuring the metabolic and EDC effects of complex environmental matrices for ecotoxicological assessment and monitoring." @default.
• W4385330275 created "2023-07-29" @default.
• W4385330275 creator A5000758423 @default.
• W4385330275 creator A5062239381 @default.
• W4385330275 creator A5085320289 @default.
• W4385330275 date "2023-07-28" @default.
• W4385330275 modified "2023-10-02" @default.
• W4385330275 title "A bioanalytical approach for assessing the effects of soil extracts from solid waste dumpsite in Calabar (Nigeria) on lipid and estrogenic signaling of fish <i>Poeciliopsis lucida</i> hepatocellular carcinoma-1 cells <i>in vitro</i> and <i>in vivo</i> African catfish (<i>Clarias gariepinus</i>)" @default.
• W4385330275 cites W1495246370 @default.
• W4385330275 cites W1964508540 @default.
• W4385330275 cites W1965380529 @default.
• W4385330275 cites W1967235584 @default.
• W4385330275 cites W1967251881 @default.
• W4385330275 cites W1971323092 @default.
• W4385330275 cites W1980484274 @default.
• W4385330275 cites W1981101682 @default.
• W4385330275 cites W1981265529 @default.
• W4385330275 cites W1981885395 @default.
• W4385330275 cites W1981976677 @default.
• W4385330275 cites W1984279963 @default.
• W4385330275 cites W1987094507 @default.
• W4385330275 cites W1987400630 @default.
• W4385330275 cites W1988609641 @default.
• W4385330275 cites W1988695122 @default.
• W4385330275 cites W1998162061 @default.
• W4385330275 cites W1999994029 @default.
• W4385330275 cites W2001959461 @default.
• W4385330275 cites W2006276740 @default.
• W4385330275 cites W2008557193 @default.
• W4385330275 cites W2009924233 @default.
• W4385330275 cites W2013573413 @default.
• W4385330275 cites W2014520536 @default.
• W4385330275 cites W2014553168 @default.
• W4385330275 cites W2026302267 @default.
• W4385330275 cites W2035101277 @default.
• W4385330275 cites W2038231323 @default.
• W4385330275 cites W2039559716 @default.
• W4385330275 cites W2042290283 @default.
• W4385330275 cites W2046981959 @default.
• W4385330275 cites W2061563606 @default.
• W4385330275 cites W2062573376 @default.
• W4385330275 cites W2066699861 @default.
• W4385330275 cites W2070164394 @default.
• W4385330275 cites W2070701674 @default.
• W4385330275 cites W2072675145 @default.
• W4385330275 cites W2073862464 @default.
• W4385330275 cites W2077394611 @default.
• W4385330275 cites W2077560419 @default.
• W4385330275 cites W2077613806 @default.
• W4385330275 cites W2078527697 @default.
• W4385330275 cites W2078826472 @default.
• W4385330275 cites W2080557342 @default.
• W4385330275 cites W2089158765 @default.
• W4385330275 cites W2091574149 @default.
• W4385330275 cites W2091673549 @default.
• W4385330275 cites W2091830214 @default.
• W4385330275 cites W2094084045 @default.
• W4385330275 cites W2097049516 @default.
• W4385330275 cites W2097722818 @default.
• W4385330275 cites W2112091114 @default.
• W4385330275 cites W2120447865 @default.
• W4385330275 cites W2131209943 @default.
• W4385330275 cites W2131699244 @default.
• W4385330275 cites W2132741387 @default.
• W4385330275 cites W2135277692 @default.
• W4385330275 cites W2138792309 @default.
• W4385330275 cites W2139513636 @default.
• W4385330275 cites W2142335554 @default.
• W4385330275 cites W2153201071 @default.
• W4385330275 cites W2162178319 @default.
• W4385330275 cites W2169023807 @default.
• W4385330275 cites W2195935960 @default.
• W4385330275 cites W2258095567 @default.
• W4385330275 cites W2258507414 @default.
• W4385330275 cites W2315155680 @default.
• W4385330275 cites W2417973383 @default.
• W4385330275 cites W2421445483 @default.
• W4385330275 cites W2591851477 @default.
• W4385330275 cites W2609199728 @default.
• W4385330275 cites W2705992066 @default.
• W4385330275 cites W2747141646 @default.
• W4385330275 cites W2754776784 @default.
• W4385330275 cites W2755689041 @default.
• W4385330275 cites W2766336051 @default.
• W4385330275 cites W2807662106 @default.
• W4385330275 cites W2811019794 @default.
• W4385330275 cites W2817900415 @default.
• W4385330275 cites W2888334755 @default.
• W4385330275 cites W2889186881 @default.
• W4385330275 cites W2898142131 @default.
• W4385330275 cites W2899700643 @default.
• W4385330275 cites W2950715268 @default.
• W4385330275 cites W2991278773 @default.
• W4385330275 cites W2992064964 @default.
• W4385330275 cites W2993238660 @default.
• W4385330275 cites W3007137886 @default.
• W4385330275 cites W3014679856 @default.
• W4385330275 cites W3035236934 @default.

• next