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• W4385330743 abstract "Aim: To codeliver an anticancer drug (doxorubicin) and siRNA in the form of nanoparticles into CD44-overexpressing colon cancer cells (HT-29) using an anionic, amphiphilic biopolymer comprising modified hyaluronic acid (6-O-[3-hexadecyloxy-2-hydroxypropyl]-hyaluronic acid). Materials & methods: Characterization of nanoparticles was performed using dynamic light scattering, scanning electron microscopy, transmission electron microscopy, molecular docking, in vitro drug release and gel mobility assays. Detailed in vitro experiments, including a gene silencing study and western blot, were also performed. Results: A 69% knockdown of the target gene was observed, and western blot showed 5.7-fold downregulation of the target protein. The repulsive forces between siRNA and 6-O-(3-hexadecyloxy-2-hydroxypropyl)-hyaluronic acid were overcome by hydrogen bonding and hydrophobic interactions. Conclusion: The authors successfully codelivered a drug and siRNA by anionic vector.Mutations in genes are the main reason for the development of cancer. siRNA can selectively downregulate the key genes responsible for a particular cancer; however, this depends on successful delivery of siRNA into cancer cells. Usually, a negatively charged cell membrane repels negatively charged siRNA, which hinders siRNA entry into cancer cells. Usually, positively charged (cationic) polymers are used to mask siRNA for crossing the cancer cell membrane. However, cationic polymers are usually toxic to the body and show several adverse effects. By contrast, negatively charged polymers are safe alternatives for delivering siRNA into cancer cells. However, the main challenge of using anionic polymer lies behind the repulsive interaction between siRNA and negatively charged vectors, as both are negative. Herein we report successful codelivery of siRNA and an anticancer drug into cancer cells using a negatively charged polymer." @default.
• W4385330743 created "2023-07-29" @default.
• W4385330743 creator A5034495441 @default.
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• W4385330743 date "2023-05-01" @default.
• W4385330743 modified "2023-10-16" @default.
• W4385330743 title "Enhanced anticancer activity of siRNA and drug codelivered by anionic biopolymer: overcoming electrostatic repulsion" @default.
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• W4385330743 doi "https://doi.org/10.2217/nnm-2022-0225" @default.
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• W4385330743 hasPublicationYear "2023" @default.
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