Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385331269> ?p ?o ?g. }
- W4385331269 endingPage "1314" @default.
- W4385331269 startingPage "1305" @default.
- W4385331269 abstract "Voriconazole is an important broad-spectrum anti-fungal drug with nonlinear pharmacokinetics. The aim of this single centre fixed-sequence open-label drug–drug interaction trial in healthy participants (N = 17) was to determine whether microdosed probe drugs for CYP3A and CYP2C19 reliably predict voriconazole clearance (CLVRZ). At baseline, a single oral microdose of the paradigm substrates midazolam (CYP3A) and omeprazole (CYP2C19) were given to estimate their clearances (CL). Thereafter, a single oral dose of voriconazole was administered (50, 100, 200 or 400 mg), followed by the microdosed probe drugs. The clearances of midazolam (CLMDZ 790–2790 mL/min at baseline; 248–1316 mL/min during voriconazole) and omeprazole (CLOMZ 66.4–2710 mL/min at baseline; 30.1–1420 mL/min during voriconazole) were highly variable. CLMDZ [geometric mean ratio (GMR) 0.586 at 50 mg voriconazole decreasing to GMR 0.196 at 400 mg voriconazole] and CLOMZ (GMR 0.590 at 50 mg decreasing to GMR 0.166 at 400 mg) were reduced with higher voriconazole doses. CLMDZ was linearly correlated with CLVRZ (slope 1.458; adjusted R2 0.528) as was CLOMZ (slope 0.807; adjusted R2 0.898). Multiple linear regression resulted in an adjusted R2 of 0.997 for the relationship CLVRZ ~ log CLOMZ + log CLMDZ using data during voriconazole treatment and an adjusted R2 of 0.997 for the relationship CLVRZ ~ log CLOMZ + log CLMDZ + voriconazole dose, using baseline data for CLMDZ and CLOMZ. Microdosed midazolam and omeprazole accurately described and predicted total CLVRZ EudraCT No: 2020-001017-20, registered on March 5th, 2020. DRKS: DRKS00022547, registered on August 6th, 2020." @default.
- W4385331269 created "2023-07-29" @default.
- W4385331269 creator A5008819108 @default.
- W4385331269 creator A5018056534 @default.
- W4385331269 creator A5018718161 @default.
- W4385331269 creator A5021921614 @default.
- W4385331269 creator A5030416479 @default.
- W4385331269 creator A5045947279 @default.
- W4385331269 creator A5047821467 @default.
- W4385331269 creator A5075947367 @default.
- W4385331269 date "2023-07-28" @default.
- W4385331269 modified "2023-10-06" @default.
- W4385331269 title "CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults" @default.
- W4385331269 cites W1990266227 @default.
- W4385331269 cites W1998659680 @default.
- W4385331269 cites W2015870178 @default.
- W4385331269 cites W2018159164 @default.
- W4385331269 cites W2020910685 @default.
- W4385331269 cites W2027820553 @default.
- W4385331269 cites W2030566485 @default.
- W4385331269 cites W2051816101 @default.
- W4385331269 cites W2095636457 @default.
- W4385331269 cites W2096212756 @default.
- W4385331269 cites W2103641008 @default.
- W4385331269 cites W2116635252 @default.
- W4385331269 cites W2285841706 @default.
- W4385331269 cites W2293178781 @default.
- W4385331269 cites W2297075820 @default.
- W4385331269 cites W2470291098 @default.
- W4385331269 cites W2562778159 @default.
- W4385331269 cites W2753025518 @default.
- W4385331269 cites W2756640276 @default.
- W4385331269 cites W2777324995 @default.
- W4385331269 cites W2791872472 @default.
- W4385331269 cites W2802117474 @default.
- W4385331269 cites W2912693327 @default.
- W4385331269 cites W2947323362 @default.
- W4385331269 cites W2951354845 @default.
- W4385331269 cites W2953189690 @default.
- W4385331269 cites W3109364475 @default.
- W4385331269 cites W4213438463 @default.
- W4385331269 cites W4214566999 @default.
- W4385331269 cites W4214886483 @default.
- W4385331269 cites W4237615604 @default.
- W4385331269 doi "https://doi.org/10.1007/s40262-023-01287-7" @default.
- W4385331269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37505445" @default.
- W4385331269 hasPublicationYear "2023" @default.
- W4385331269 type Work @default.
- W4385331269 citedByCount "0" @default.
- W4385331269 crossrefType "journal-article" @default.
- W4385331269 hasAuthorship W4385331269A5008819108 @default.
- W4385331269 hasAuthorship W4385331269A5018056534 @default.
- W4385331269 hasAuthorship W4385331269A5018718161 @default.
- W4385331269 hasAuthorship W4385331269A5021921614 @default.
- W4385331269 hasAuthorship W4385331269A5030416479 @default.
- W4385331269 hasAuthorship W4385331269A5045947279 @default.
- W4385331269 hasAuthorship W4385331269A5047821467 @default.
- W4385331269 hasAuthorship W4385331269A5075947367 @default.
- W4385331269 hasBestOaLocation W43853312691 @default.
- W4385331269 hasConcept C112705442 @default.
- W4385331269 hasConcept C11824378 @default.
- W4385331269 hasConcept C126322002 @default.
- W4385331269 hasConcept C140840227 @default.
- W4385331269 hasConcept C16005928 @default.
- W4385331269 hasConcept C2777498785 @default.
- W4385331269 hasConcept C2779548794 @default.
- W4385331269 hasConcept C2780690907 @default.
- W4385331269 hasConcept C526171541 @default.
- W4385331269 hasConcept C62231903 @default.
- W4385331269 hasConcept C71924100 @default.
- W4385331269 hasConcept C90924648 @default.
- W4385331269 hasConcept C98274493 @default.
- W4385331269 hasConceptScore W4385331269C112705442 @default.
- W4385331269 hasConceptScore W4385331269C11824378 @default.
- W4385331269 hasConceptScore W4385331269C126322002 @default.
- W4385331269 hasConceptScore W4385331269C140840227 @default.
- W4385331269 hasConceptScore W4385331269C16005928 @default.
- W4385331269 hasConceptScore W4385331269C2777498785 @default.
- W4385331269 hasConceptScore W4385331269C2779548794 @default.
- W4385331269 hasConceptScore W4385331269C2780690907 @default.
- W4385331269 hasConceptScore W4385331269C526171541 @default.
- W4385331269 hasConceptScore W4385331269C62231903 @default.
- W4385331269 hasConceptScore W4385331269C71924100 @default.
- W4385331269 hasConceptScore W4385331269C90924648 @default.
- W4385331269 hasConceptScore W4385331269C98274493 @default.
- W4385331269 hasFunder F4320330130 @default.
- W4385331269 hasIssue "9" @default.
- W4385331269 hasLocation W43853312691 @default.
- W4385331269 hasLocation W43853312692 @default.
- W4385331269 hasOpenAccess W4385331269 @default.
- W4385331269 hasPrimaryLocation W43853312691 @default.
- W4385331269 hasRelatedWork W1952558609 @default.
- W4385331269 hasRelatedWork W2047763035 @default.
- W4385331269 hasRelatedWork W2098187188 @default.
- W4385331269 hasRelatedWork W2400119402 @default.
- W4385331269 hasRelatedWork W2995148693 @default.
- W4385331269 hasRelatedWork W4214886483 @default.
- W4385331269 hasRelatedWork W4377967821 @default.