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- W4385331413 abstract "Colorectal cancer (CRC) therapy is a big challenge, and seeking an effective and safe drug is a pressing clinical need. Gambogic acid is a potent antineoplastic agent without the drawback of bone marrow suppression. To improve its druggability (e.g., poor water solubility and tumor delivery), a lactoferrin-modified gambogic acid liposomal delivery system (LF-lipo) was developed to enhance the treatment efficacy of CRC. The LF-lipo can specifically bind LRP-1 expressed on colorectal cancer cells to enhance drug delivery to the tumor cells and yield enhanced therapeutic efficacy. The LF-lipo promoted tumor cell apoptosis and autophagy, reduced reactive oxygen species (ROS) levels in tumor cells, and inhibited angiogenesis; moreover, it could also repolarize tumor-associated macrophages from the M2 to M1 phenotype and induce ICD to activate T cells, exhibiting the capability of remodeling the tumor immune microenvironment. The liposomal formulation yielded an efficient and safe treatment outcome and has potential for clinical translation." @default.
- W4385331413 created "2023-07-29" @default.
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- W4385331413 date "2023-07-28" @default.
- W4385331413 modified "2023-10-17" @default.
- W4385331413 title "Lactoferrin-Modified Gambogic Acid Liposomes for Colorectal Cancer Treatment" @default.
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- W4385331413 doi "https://doi.org/10.1021/acs.molpharmaceut.3c00052" @default.
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