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- W4385331508 abstract "Objective This study aimed to investigate the relationship between 18 F-fluorodeoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) metabolic parameters and clinical benefit and prognosis in nonsmall cell lung cancer (NSCLC). Methods In total, 34 advanced NSCLC patients who received 18 F-FDG PET/CT before immunotherapy were retrospectively included in this study. All patients were divided into two groups, the clinical benefit (CB) group and the no-clinical benefit (no-CB) group, based on the efficacy of evaluation after 6 months of treatment. Also clinical information, characteristics of metastases, survival, PD-L1 expression level and glucose metabolic parameters were evaluated. Results Finally, 24 patients were in the CB group, and 10 patients were in the no-CB group. There was a significant difference between the CB group and the no-CB group in TNM stages ( P = 0.005), visceral and bone metastasis ( P = 0.031), metabolic tumor volume of primary lesion (MTV-P; P = 0.003), the metabolic tumor volume of whole-body (MTVwb; P = 0.005) and total lesion glycolysis of whole-body (TLGwb, P = 0.015). However, for patient outcomes, the independent prognostic factors associated with progression free survival were TNM stage (HR = 0.113; 95% CI, 0.029–0.439; P = 0.002), TLG-P (HR = 0.085; 95% CI, 0.018–0.402; P = 0.002) and TLG-LN (HR = 0.068; 95% CI, 0.015–0.308; P = 0.000), and the TLG-LN (HR = 0.242; 95% CI, 0.066–0.879; P = 0.002) was the independent prognostic factor associated with overall survival. Conclusions Metastatic lesion burden evaluated by 18 F-FDG PET/ CT can predict response to immunotherapy in advanced NSCLC patients, in which lymph node metastasis lesion metabolic burden is a meaningful predictor, but a large multicenter trial is still needed to validate this conclusion." @default.
- W4385331508 created "2023-07-29" @default.
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- W4385331508 date "2023-07-31" @default.
- W4385331508 modified "2023-09-25" @default.
- W4385331508 title "18F-FDG PET/CT for evaluation of metastases in nonsmall cell lung cancer on the efficacy of immunotherapy" @default.
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- W4385331508 doi "https://doi.org/10.1097/mnm.0000000000001737" @default.
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