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- W4385332785 abstract "ABSTRACT Recent studies have highlighted the heterogeneity of the immune cell compartment within the steady-state murine and human CNS. However it is not known whether this diversity is conserved among non mammalian vertebrates, especially in the zebrafish, a model system with increasing translational value. Here, we reveal the complexity of the immune landscape of the adult zebrafish brain. Using single-cell transcriptomics, we characterized these different immune cell subpopulations, including cell types that have not been -or have been poorly-characterized in zebrafish so far. By histology, we found that, despite microglia being the main immune cell type in the parenchyma, the zebrafish brain is also populated by a distinct myeloid population that shares a gene signature with mammalian dendritic cells (DC). Notably, zebrafish DC-like cells rely on batf3 , a gene essential for the development of conventional DC1 in the mouse. Using specific fluorescent reporter lines that allowed us to reliably discriminate DC-like cells from microglia, we quantified brain myeloid cell defects in commonly used irf8 -/- , csf1ra -/- and csf1rb -/- mutant fish, revealing previously unappreciated distinct microglia and DC-like phenotypes. Overall, our results suggest a conserved heterogeneity of brain immune cells across vertebrate evolution and also highlights zebrafish-specific brain immunity characteristics." @default.
- W4385332785 created "2023-07-29" @default.
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- W4385332785 date "2023-07-28" @default.
- W4385332785 modified "2023-10-02" @default.
- W4385332785 title "A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma" @default.
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- W4385332785 doi "https://doi.org/10.1101/2023.07.27.550829" @default.
- W4385332785 hasPublicationYear "2023" @default.
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