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- W4385335109 abstract "Abstract Striatal pathways control motivation and movement; however, their role in cognition is unclear. We studied dorsomedial striatal cognitive processing during interval timing, an elementary cognitive task that requires mice to estimate intervals of several seconds. Interval timing involves working memory for temporal rules and attention to the passage of time. We discovered that both pharmacological and optogenetic disruptions of D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) or D1-dopamine receptor-expressing MSNs (D1-MSNs) delayed timing. Disrupting D2-MSNs or D1-MSNs did not affect task-specific movements. Furthermore, pharmacological blockade of D2-dopamine receptors or D1-dopamine receptors degraded dorsomedial MSN temporal encoding. We compared the timing-related firing of optogenetically-tagged D2-MSNs and D1-MSNs. Strikingly, we found that D2-MSNs and D1-MSNs exhibited opposite dynamics over temporal intervals despite similar effects of D2-MSN and D1-MSN disruptions. MSN dynamics helped construct and constrain a four-parameter drift-diffusion computational model that captured interval timing behavior and D2-MSN and D1-MSN perturbations. Despite opposing dynamics, disrupting either D2-MSNs or D1-MSNs slowed timing, implying that D2-MSNs and D1-MSNs make complementary contributions to interval timing. These data provide novel insight into basal ganglia cognitive operations beyond movement. Our findings carry implications for a broad range of human striatal diseases and for therapies targeting striatal pathways." @default.
- W4385335109 created "2023-07-29" @default.
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- W4385335109 date "2023-07-28" @default.
- W4385335109 modified "2023-09-26" @default.
- W4385335109 title "Complementary cognitive roles for D2-MSNs and D1-MSNs in interval timing" @default.
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- W4385335109 cites W1987332330 @default.
- W4385335109 cites W1987953899 @default.
- W4385335109 cites W1992910467 @default.
- W4385335109 cites W1993146792 @default.
- W4385335109 cites W1997843515 @default.
- W4385335109 cites W1999791805 @default.
- W4385335109 cites W2000621650 @default.
- W4385335109 cites W2002935439 @default.
- W4385335109 cites W2012493789 @default.
- W4385335109 cites W2012509205 @default.
- W4385335109 cites W2020361904 @default.
- W4385335109 cites W2023057624 @default.
- W4385335109 cites W2023215474 @default.
- W4385335109 cites W2025666055 @default.
- W4385335109 cites W2031170958 @default.
- W4385335109 cites W2038698792 @default.
- W4385335109 cites W2045839462 @default.
- W4385335109 cites W2051211720 @default.
- W4385335109 cites W2057029832 @default.
- W4385335109 cites W2060588252 @default.
- W4385335109 cites W2064319583 @default.
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- W4385335109 cites W2074651284 @default.
- W4385335109 cites W2078244648 @default.
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- W4385335109 cites W2090278355 @default.
- W4385335109 cites W2102132106 @default.
- W4385335109 cites W2103243650 @default.
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- W4385335109 cites W2140362232 @default.
- W4385335109 cites W2148537626 @default.
- W4385335109 cites W2155694557 @default.
- W4385335109 cites W2160643956 @default.
- W4385335109 cites W2163433107 @default.
- W4385335109 cites W2164011442 @default.
- W4385335109 cites W2164146725 @default.
- W4385335109 cites W2164789388 @default.
- W4385335109 cites W2226550946 @default.
- W4385335109 cites W2284921205 @default.
- W4385335109 cites W2312055187 @default.
- W4385335109 cites W2315767303 @default.
- W4385335109 cites W2495730383 @default.
- W4385335109 cites W2559760094 @default.
- W4385335109 cites W2560240428 @default.
- W4385335109 cites W2564240520 @default.
- W4385335109 cites W2564687799 @default.
- W4385335109 cites W2591800019 @default.
- W4385335109 cites W2592710662 @default.
- W4385335109 cites W2742906651 @default.
- W4385335109 cites W2761617879 @default.
- W4385335109 cites W2772691327 @default.
- W4385335109 cites W2774249868 @default.
- W4385335109 cites W2786017571 @default.
- W4385335109 cites W2788593837 @default.
- W4385335109 cites W2804780080 @default.
- W4385335109 cites W2809220750 @default.
- W4385335109 cites W2890374678 @default.
- W4385335109 cites W2917576966 @default.
- W4385335109 cites W3082383809 @default.
- W4385335109 cites W3082843271 @default.
- W4385335109 cites W3112310697 @default.
- W4385335109 cites W3131749333 @default.
- W4385335109 cites W3171273749 @default.
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- W4385335109 doi "https://doi.org/10.1101/2023.07.25.550569" @default.
- W4385335109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37546735" @default.
- W4385335109 hasPublicationYear "2023" @default.
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