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- W4385335912 abstract "Ca<sup>2+</sup> in cardiac myocyte are mainly stored in the sarcoplasmic reticulum (SR), the disturbance of Ca<sup>2+</sup> dynamics in the SR can cause various cardiovascular diseases. However, there is a lack of research on regulatory mechanism of SR Ca<sup>2+</sup> . In this paper, we developed a spatially-detailed numerical model for Ca<sup>2+</sup> blink to analyze Ca<sup>2+</sup> spatiotemporal dynamic characteristics in junctional SR (jSR) cisternae of rabbit cardiomyocytes. The geometric model is constructed by 2- dimensional unstructured triangular meshes with a combined method of Delaunay Triangulations (DT) and Advancing Front Technique (AFT). The numerical method for solving the governing equations adopts Basic Function Method based on unstructured triangular meshes. Finally, our model is well reproduced the SR Ca<sup>2+</sup> kinetics of Ca<sup>2+</sup> blink and simulated results well match the results of a recent biological experiment." @default.
- W4385335912 created "2023-07-29" @default.
- W4385335912 creator A5014113558 @default.
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- W4385335912 date "2023-07-28" @default.
- W4385335912 modified "2023-09-24" @default.
- W4385335912 title "The numerical model for sarcoplasmic reticulum Ca2+ blink in rabbit cardiomyocytes" @default.
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- W4385335912 doi "https://doi.org/10.1117/12.2685897" @default.
- W4385335912 hasPublicationYear "2023" @default.
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