Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385335964> ?p ?o ?g. }
- W4385335964 endingPage "113334" @default.
- W4385335964 startingPage "113334" @default.
- W4385335964 abstract "Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of the gastrointestinal tract. The etiology is not fully understood, but environmental, microbial, and immunologic factors, as well as a genetic predisposition, play a role. UC is characterized by episodes of abdominal pain, diarrhea, bloody stools, weight loss, severe colonic inflammation, and ulceration. Despite the increase in the frequency of UC and the deterioration of the quality of life, there are still patients who do not respond well to available treatment options. Against this background, natural products such as polysaccharides are becoming increasingly important as they protect the intestinal mucosa, promote wound healing, relieve inflammation and pain, and restore intestinal motility. In this study, we investigated the effect of a polysaccharide isolated from the biomass of Campomanesia adamantium and Campomanesia pubescens (here referred to as CPW) in an experimental model of acute and chronic ulcerative colitis induced by dextran sulfate sodium (DSS). CPW reversed weight loss, increased disease activity index (DAI), bloody diarrhea, and colon shortening. In addition, CPW reduced visceral mechanical hypersensitivity, controlled oxidative stress and inflammation, and protected the mucosal barrier. CPW is not absorbed in the intestine, does not inhibit cytochrome P450 proteins, and does not exhibit AMES toxicity. These results suggest that CPW attenuates DSS-induced acute and chronic colitis in mice and may be a potential alternative treatment for UC." @default.
- W4385335964 created "2023-07-29" @default.
- W4385335964 creator A5000951547 @default.
- W4385335964 creator A5004995308 @default.
- W4385335964 creator A5007756513 @default.
- W4385335964 creator A5012947375 @default.
- W4385335964 creator A5027005360 @default.
- W4385335964 creator A5042429482 @default.
- W4385335964 creator A5045766189 @default.
- W4385335964 creator A5049432361 @default.
- W4385335964 creator A5057686719 @default.
- W4385335964 creator A5059802003 @default.
- W4385335964 creator A5061076198 @default.
- W4385335964 creator A5064269413 @default.
- W4385335964 creator A5072833434 @default.
- W4385335964 creator A5078621546 @default.
- W4385335964 creator A5084711108 @default.
- W4385335964 creator A5091030450 @default.
- W4385335964 date "2023-11-01" @default.
- W4385335964 modified "2023-10-08" @default.
- W4385335964 title "CPW partially attenuates DSS-induced ulcerative colitis in mice" @default.
- W4385335964 cites W1596258860 @default.
- W4385335964 cites W1855226200 @default.
- W4385335964 cites W1971472562 @default.
- W4385335964 cites W1979658180 @default.
- W4385335964 cites W2006195533 @default.
- W4385335964 cites W2018075167 @default.
- W4385335964 cites W2020358486 @default.
- W4385335964 cites W2027009883 @default.
- W4385335964 cites W2057574272 @default.
- W4385335964 cites W2061333433 @default.
- W4385335964 cites W2063576996 @default.
- W4385335964 cites W2064905341 @default.
- W4385335964 cites W2075762190 @default.
- W4385335964 cites W2085738299 @default.
- W4385335964 cites W2088866343 @default.
- W4385335964 cites W2090632754 @default.
- W4385335964 cites W2098655668 @default.
- W4385335964 cites W2110936821 @default.
- W4385335964 cites W2111833153 @default.
- W4385335964 cites W2119546263 @default.
- W4385335964 cites W2162932896 @default.
- W4385335964 cites W2167454474 @default.
- W4385335964 cites W2177537276 @default.
- W4385335964 cites W2239450140 @default.
- W4385335964 cites W2283762488 @default.
- W4385335964 cites W2297123985 @default.
- W4385335964 cites W2401851659 @default.
- W4385335964 cites W2507575989 @default.
- W4385335964 cites W2555128861 @default.
- W4385335964 cites W2586155766 @default.
- W4385335964 cites W2620756707 @default.
- W4385335964 cites W2749814893 @default.
- W4385335964 cites W2766952390 @default.
- W4385335964 cites W2780828301 @default.
- W4385335964 cites W2782039643 @default.
- W4385335964 cites W2801650643 @default.
- W4385335964 cites W2886213241 @default.
- W4385335964 cites W2887945091 @default.
- W4385335964 cites W2888169988 @default.
- W4385335964 cites W2905069116 @default.
- W4385335964 cites W2907882868 @default.
- W4385335964 cites W2911583413 @default.
- W4385335964 cites W2926149212 @default.
- W4385335964 cites W2982557769 @default.
- W4385335964 cites W2988542752 @default.
- W4385335964 cites W2991550463 @default.
- W4385335964 cites W3001780488 @default.
- W4385335964 cites W3005327708 @default.
- W4385335964 cites W3005365020 @default.
- W4385335964 cites W3008030891 @default.
- W4385335964 cites W3015066429 @default.
- W4385335964 cites W3015694861 @default.
- W4385335964 cites W3028769639 @default.
- W4385335964 cites W3030879056 @default.
- W4385335964 cites W3034743752 @default.
- W4385335964 cites W3038003900 @default.
- W4385335964 cites W3044242495 @default.
- W4385335964 cites W3081479943 @default.
- W4385335964 cites W3084081817 @default.
- W4385335964 cites W3086885273 @default.
- W4385335964 cites W3093298532 @default.
- W4385335964 cites W3095353222 @default.
- W4385335964 cites W3096288974 @default.
- W4385335964 cites W3109212742 @default.
- W4385335964 cites W3124270040 @default.
- W4385335964 cites W3157493516 @default.
- W4385335964 cites W3170162444 @default.
- W4385335964 cites W3179905314 @default.
- W4385335964 cites W3188937228 @default.
- W4385335964 cites W3198505778 @default.
- W4385335964 cites W3204318352 @default.
- W4385335964 cites W3204720697 @default.
- W4385335964 cites W3217067154 @default.
- W4385335964 cites W349993746 @default.
- W4385335964 cites W4200140061 @default.
- W4385335964 cites W4210258765 @default.
- W4385335964 cites W4211153467 @default.